Guest guest Posted March 8, 2004 Report Share Posted March 8, 2004 Hi , I don't understand - from the article I read about PTC124, the pill seemed to work on any mutation that was a stop. In fact, it works on other diseases where stop mutations caused a problem. There was no indication in the article that it would work on some stop mutations, but not others. How did the doctor describe the interaction of the drug on the mutations to you to make you believe it wouldn't work on all stop mutations? C Mommy to Mick and Alli, 4 yo twins wcf --- dwson2 wrote: > Oh No. I was hoping it did mean that it would work > for all stop > mutations. Just our luck, Zach has a rare stop > mutation. I was so > hoping he caught a break. Only time will tell I > guess. > Sara > > I don't think that the med would apply to most > splice mutations and > maybe not even to all stop mutations? Just from my > understanding of > what the doc explained......... > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 9, 2004 Report Share Posted March 9, 2004 Well, it was about a month or so ago that he mentioned that it was " in the pipeline " for the med to be used in class one mutations and he seemed like he was unsure if it would even work on all stop mutations for CF (something about where the stop is in the chain). We did not discuss the stop mutations at length because 's mutation is a splice mutation, and I was more concerned with if it would work on splices........ The whole thing was a bit confusing to me actually but it seemed more hopeful for stop mutations than splices. Re: Re: " stop " mutations - Hi , I don't understand - from the article I read about PTC124, the pill seemed to work on any mutation that was a stop. In fact, it works on other diseases where stop mutations caused a problem. There was no indication in the article that it would work on some stop mutations, but not others. How did the doctor describe the interaction of the drug on the mutations to you to make you believe it wouldn't work on all stop mutations? C Mommy to Mick and Alli, 4 yo twins wcf --- dwson2 wrote: > Oh No. I was hoping it did mean that it would work > for all stop > mutations. Just our luck, Zach has a rare stop > mutation. I was so > hoping he caught a break. Only time will tell I > guess. > Sara > > I don't think that the med would apply to most > splice mutations and > maybe not even to all stop mutations? Just from my > understanding of > what the doc explained......... > > > > > ------------------------------------------- The opinions and information exchanged on this list should IN NO WAY be construed as medical advice. PLEASE CONSULT YOUR PHYSICIAN BEFORE CHANGING ANY MEDICATIONS OR TREATMENTS. ------------------------------------ ------------------------------------------------------------------------------ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 9, 2004 Report Share Posted March 9, 2004 Hi , Thanks for explaining that to me. I may try to get more information on the researchers doing the phase 2 trials and ask them if they've had any luck with splice mutations, or if they've even been looking at that, and also if there are any stop mutations that would not respond to the drug. hugs, C Mommy to Mick and Alli, 4 yo twins wcf --- ANDREA FITTING wrote: > Well, it was about a month or so ago that he > mentioned that it was " in the pipeline " for the med > to be used in class one mutations and he seemed like > he was unsure if it would even work on all stop > mutations for CF (something about where the stop is > in the chain). We did not discuss the stop > mutations at length because 's mutation is a > splice mutation, and I was more concerned with if it > would work on splices........ The whole thing was a > bit confusing to me actually but it seemed more > hopeful for stop mutations than splices. > > Re: Re: " stop " mutations - > > > > Hi , > > I don't understand - from the article I read about > PTC124, the pill seemed to work on any mutation > that > was a stop. In fact, it works on other diseases > where > stop mutations caused a problem. There was no > indication in the article that it would work on > some > stop mutations, but not others. > > How did the doctor describe the interaction of > the drug on the mutations to you to make you > believe it wouldn't work on all stop mutations? > > C > Mommy to Mick and Alli, 4 yo twins wcf > > --- dwson2 wrote: > > Oh No. I was hoping it did mean that it would > work > > for all stop > > mutations. Just our luck, Zach has a rare stop > > mutation. I was so > > hoping he caught a break. Only time will tell I > > guess. > > Sara > > > > I don't think that the med would apply to most > > splice mutations and > > maybe not even to all stop mutations? Just from > my > > understanding of > > what the doc explained......... > > > > > > > > > > > > > ------------------------------------------- > The opinions and information exchanged on this > list should IN NO WAY > be construed as medical advice. > > PLEASE CONSULT YOUR PHYSICIAN BEFORE CHANGING ANY > MEDICATIONS OR TREATMENTS. > > ------------------------------------ > > > > > ------------------------------------------------------------------------------ > Quote Link to comment Share on other sites More sharing options...
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