[Fwd: Re: Re: MB12 Questions/References]

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I am going to forward a few archive message on MB12 (this is not the

same thing as B12) and the shots are NOT intramuscular. I was going

to suggest doing an advance search in the archives for " MB12 in the

title " but I saw quite a lot of those talking about B12 intramuscular

shots, not the subcutaneous MB12 shots - two different things.

MB12 is available in sublingual drops, lozenges, transdermal, nasal

spray and subcutaneous shots given using an insulin needled just under

the skin - the needle is very tiny and fine. Some batches of the shots

have been reported to " burn " because they have a pH that is too

high...in that case, stop the shots and call the compounding pharmacy

who will replace them for free with a new batch. These shots, like the

nasal spray do not contain preservatives and need to be kept in the

fridge for that reason. They normally are good for 3 months, depending

on when the MB12 batch from which there were prepared was made...there

will be date on the packaging. They are also water soluble and the body

will expel them via the urine if in excess.

In the below archive there are some links which speak about MB12

therapies. Not all people respond to or tolerate the MB12 form of B12

though...keep that in mind. It depends on how their methylation cycle

is " broken " and unable to convert regular B12 (cyanocobalamin) into

methylcobalamin.

25June2007 momresearch wrote:

Liz ha scritto:

>> What does MB12 do exactly? I guess what I am asking is what is the

>> kid missing or exhibiting if the conversion is not made properly?

>>

Hi

PREFACE: these articles mention the word " autism " but that is because

most of the research being conducted and shared so far is in that

context...this does NOT mean that these things are unique to " autism "

and does NOT imply that the late talkers, and children with

apraxia/dyspraxia have autism...please take the information supplied as

a generic synopsis of therapies being used in children with immune

system and neurological developmental difficulties (apraxia-dyspraxia is

also considered neurodevelopmental condition).

_*Not all children have a problem** with B12 being metabolized to

MB12.*_..it is only when they do have problem in the methylation cycle

that giving them MB12 already converted seems to help the majority of

those children. A blood test for B12 levels is not a reliable indicator

of the need for B12/MB12...high blood levels can also mean that the body

is not processing the B12 correctly, thus throwing it away. MB12 is

important in the production of glutathione which is helpful in the

body's oxidation processes - and detox abilities...and more...

For those of you interested in learning more about this topic below are

some links - it's not easy reading, especially if you are new to

biomedical treatments, so perhaps we should consider it " advanced "

therapies in some cases because I don't want everyone brand new to

dyspraxia-apraxia world to think they need rush right out and do this

treatment. You shouldn't and can't do the treatment without a medical

professional's intervention knowledgeable in this topic (most

pediatricians will look at you like you're looney) -- it does require a

prescription because it has to be specially compounded and dosed based

on the individual's needs).

I would like to also take advantage of this note to remind everyone that

biomedical helps (like fish oils, carnitine, etc) are helpful but should

be combined with the traditional helps like apraxia-trained speech,

listening, and sensory therapy strategies, communication interactions at

the child's level, etc; a good individualized education plan

(IEP)...etc. There is no one magic pill or solution. A

multi-disciplinary treatment plan is the best goal to work towards.

There is quite a bit of information by Drs. Deth and Jill

http://www.autismone.org/uploads/2006/Deth%20.ppt

Deth:

*http://tinyurl.com/37hamf*

<http://www.reform.house.gov/UploadedFiles/Testimony%20%20Deth.pdf>

Jill :

*http://tinyurl.com/869ec

*

There's more info on MB12 shots at www.drneubrander.com

Stan Kurtz offers information and video presentations on MB12 nasal

spray at

http://www.childrenscornerschool.com/mb12nasalspray.htm

www.recoveryvideos.com

and a discussion group at www./group/mb12 valtrex

Here's an excerpt from http://www.udaan.org/autism/proforma.html where

MB12 was included in a broader study of treatments:

Vitamin MB12 Therapy

In the process of intestinal absorption and subsequent transfer into

peripheral tissue, folic acid is converted into Dihydrofolate (DHF) by

the Dihydrofolate Reductase enzyme (DHFR). DHF is then metabolized into

Tetrahydrofolate (THF) again by DHFR. THF is metabolized into

5,10-Methylene-THF. 5,10-Methylene-THF is converted to L-methylfolate by

the Methyltetrahydrofolate Reductase enzyme (MTHFR). The methyl radical

is transferred to Vitamin B12 (Vitamin MB12), which helps convert

Homocysteine to Methionine, which then transfers the methyl radical for

methylation of DNA, RNA, Protein Membrane Phospholipids and Creatine,

while the remnant molecule again goes on to form Homocysteine ' Cysteine

' Glutathione.

One of the genetic-induced deficiencies seen in about 2/3rd of Autism

cases is deficiency of the key enzyme Methylene Tetra Hydro Folate

Reductase (MTHFR).

1. Deficiency of Vitamin MB12 manufacture leads to defective neural

activity as well as Glutathione deficiency. US reports suggest

that symptoms of such deficiency and its amelioration with

supplement of vitamin MB12 subcutaneous injections, is recorded in

about 60 % of autism affected children. Blood MTHFR levels can be

tested at Delhi

2. Glutathione is not only responsible for Free Radical Scavenging

action at the intracellular level, but also for removing heavy

metals accumulation from brain cells. Deficiency of Glutathione

affects body immune activity, cell protection activity and heavy

metal extraction and excretion capacity. Deficiency of blood

Glutathione levels has been reported in autistic children in USA

3. Vitamin MB12 has very negligible storage in the body. Any dose

given by oral, IM or IV route reaches peak blood levels very fast

and is excreted in urine within a few hours only. This is not

conducive to the production of a sustained flat blood level of

vitamin MB12 to manufacture a continuous 24 hour level of adequate

amounts of Methionine / Glutathione by the MTHFR route

4. The answer to this problem, as practiced in USA, is to use a

concentrated formulation of Vitamin MB12 (10 or 25 mg/ml) in order

to reduce surface area of the required volume of the

subcutaneously injected drug, to delay absorption rate. The drug

is only injected by the subcutaneous route into the gluteal fat

because of its low vascularity which further delays absorption

rate. In addition, this area also has a low sensory nerve supply

to reduce injection discomfort. Using this formulation,

methodology, route and area, it is possible to maintain the

desired therapeutic blood level of vitamin methyl B12 for three

days per injection

5. It is expected that this will restore vitamin MB12 levels,

methionine levels, DNA/RNA signaling mechanisms and normalize

Glutathione levels to help protect the body and enhance

Glutathione-mediated extraction of heavy metals like mercury from

brain cells, to improve the autistic state, as measured by the

standard CARS Scale for children with autism

/*To quote Stan Kurtz'

" None of this document's information has been approved by the Food and

Drug Administration and it was written by a parent and independent

researcher who is not credentialed. This information is based on

published medical literature and anecdotes, and should not be considered

medical advice. " */

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