Vitamin E information

[Guest guest]

,

I think you said you are having trouble with archives so I pasted

message # 58564 from Dr. on the discussion of vitamin E use:

" I am not going to debate about what is published on upper safety

limits. You can go back to the earlier discussions on vit E over the

last year if you want more info. I did a huge research effort before

I started my son on vit E (began at 400 iu), including contacting

authors of text-book chapters etc. These upper limits are not based

on anything scientific. The 1500 iu upper limit comes from a rat

study where they saw impact on vit K with 300 X that does...so just

imagine the mg/kg of over 30,000 mg of vit E in a timy rat. (Even a

big rat). At that level vit K was effected. The pediatric doses are

pretty darn random. You need to do what you feel comfortable with.

But at 20 months it is hard to know whether your child is apraxic -

and whether there really is an increased need for vit E in the first

place. In children with apraxia having symptoms that overlap the

signs of vit E deficiency - this may be a worthwhile approach. But

normal kids don't have or need this much vit e...although 400 iu

should not be a problem. Again, everything has possible side

effects. A dose of motrin for that fever could cause a susceptible

child to have a significiant intestinal bleed, but most people don't

think twice about giving motrin. And most people don't have bleeding

issues. But if you are one of the rare events, that " rare " warning

doesn't help the effected individual. These are uncharted waters.

They come with no recommendations or reassurances. But still, if you

read the merck manual description of vit E...you will feel better.

There have been several poorly done meta-analyses on vit E that the

media has gotten a hold of, where the conclusions are not justified

based on the data. In fact MOST vit E studies done show benefits for

cardiovascular disease and inflammatory conditions. Many studies use

synthetic vit E which is also a problem. The bottom line is that

for kids who respond to vit E...they have some medical condition that

is effecting their neurological system that involves vit E. That

makes them different from the normal child. And in that child, not

addressing the deficiencies will lead to persistent symptoms. If a

trial of vit E does nothing - then that is probably not part of the

contributing mechanism, and high doses should not be used.

- "

The labs for apraxia message: #53124 may also help you:

Blood tests to consider for kids with apraxia

Celiac panel

Vitamin E plasma levels (alpha and gamma)

Other fat soluble vitamins (A, D, K) (Many have fat malabsorption)

Metabolic studies: Lead level, CBC, complete metabolic panel, plasma

quant amino acids

carnitine (total, free, esters), acyl-carnitine panel (plasma),

urine organic acids, lactic acid, comprehensive fatty acid profile

(C8-26) -

a sendout to Mayo clinic - but other labs do it too.(rule out

metabolic disorder as cause of severe neurodevelopmental disorder -

apraxia/dyspraxia).

Celiac pane includes:

serum for

1) human tissue transglutaminase antibodies (TTG),

2) antiendomysial antibodies (EMA),

3) anti-gliadin IgA antibody,

4) anti-gliadin IgG antibody, and

5) total immunoglobulin A.

Consider below:

Supplement with omega 3/6/9 (2 caps) + 1 EPA given 2-3 times a day.

(Twice a

day may be sufficient with Vit E)

Vit E (alpha " d " tocophorol) NOT synthetic " dl " 400 IU

Gamma tocophorol 200-300 mg day

Consider comprehensive multivit. Marilyn Agin recommended the

following to

me: Super NuThera from Kirkman's Labs (tastes nasty)

http://www.kirkmanlabs.com/products/multivitamins/super_nuthera/snt_3

07_454.

html.

L-Carnitine if testing shows a deficit.

Consider a trial of gluten/casein free diet, but I would give the

above supplements at least a month or 2, since the diet may not be

necessary? Unless celiac positive, of course. Then gluten-free is

essential.

Best wishes!

Liz