Guest guest Posted April 14, 2009 Report Share Posted April 14, 2009 anyone that has their child on fish oils has their child on vitamin E to some extent. I know you believe it's the vitamin K that created all the issues but I did extensive searching on vitamin E after many of our children including my own had issues and learned more than I wanted to about hypervitaminosis. If you check the archives I posted a few of the rare stories of those who experimented with mega dosages of vitamin E and in a nutshell hypervitaminosis is vitamin poisening. My son is my height at 12 years old and had such a severe regression it took months to get him back -and it's documented not only by professionals but everyone at his school (they thought I had put him on some medication) It was horrific. In addition we still have the unknown with 's child Evoni. In my opinion there are far too many things out there that we know to be benign and effective to encourage parents to explore something that we already in this group found can cause severe side effects for unknown reasons. And PS -what is " mega dosage " for a 2 year old if 400 IUS of vitamin E is considered high dosage and " High-dosage (> or =400 IU/d) vitamin E supplements may increase all-cause mortality and should be avoided " ??? Evoni was only 2 years old. You want to know exactly how I feel ? I feel like I poisened my son -myself -and talk about guilt from that. No way am I letting anyone here talk about vitamin E without me sharing what I learned. Hey if you study the side effects and still wish to try it with your child in higher dosages than what they would get in their diet -or what is added in the fish oil capsules -then at least you are going in with open eyes. I wish someone warned me or this group prior to recommending vitamin E. Again it was me that found the hypervitaminosis information and reported it here -after my son and others had side effects and regressed. And by the way just like the fish oils worked within a few days for most of us -with this vitamin E in higher dosages the side effects were also in a few days -but unlike the fish oils they were to the extreme negative. And for my son and a few others -they didn't just go away once the supplement was stopped. And up to as recently as a month or so ago -just trying to give Tanner one capsule of 200 IUs of vitamin E he gets a headache -and the only time he ever got headaches was while Here's a bunch of info from the archives -can't read it all again so sorry if there are repeats -but hope you get the idea that yes it " could " be the vitamin E causing the issues. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. ER 3rd, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. The s Hopkins School of Medicine, and The Welch Center for Prevention, Epidemiology and Clinical Research, The s Hopkins Medical Institutions, Baltimore, land 21205-2223, USA. ermiller@... CONCLUSION: High-dosage (> or =400 IU/d) vitamin E supplements may increase all-cause mortality and should be avoided. http://www.ncbi.nlm.nih.gov/pubmed/15537682 Meta-analyses from and colleagues and from Bjelakovic and coauthors found that vitamin E supplementation increases all-cause mortality. These studies raised concerns on the long-term safety of high-dose vitamin E supplementation.2,10 Increased mortality - 's meta-analysis looked at dose-response relationships between vitamin E supplementation and total mortality.2 Nine out of 11 trials using high doses of vitamin E (400 IU or more) showed a significant increase in all-cause mortality in the vitamin E group. As the authors pointed out, however, the extent to which these findings can be generalized is unclear, because the high-dose trials were often small and were conducted on patients with chronic diseases.2 In Bjelakovic's meta-analysis, vitamin E, singly or combined with other antioxidants, was associated with a small but nonetheless significant (relative risk [RR], 1.04; 95% confidence interval [CI], 1.01-1.07) mortality increase.10 Congestive heart failure - The Heart Outcomes Prevention Evaluation-The Ongoing Outcomes (HOPE-TOO) was a randomized trial examining the effects of 400 IU of vitamin E versus those of a placebo in patients with diabetes or vascular disease. After a mean 7.2 years of follow-up, vitamin E did not decrease the incidence of cancer deaths or vascular events, but evidence indicated that it did increase the incidence of heart failure (reference range, 1.19, P =.007).8,11,12,13,14,15,16,17 Coagulopathy - An increased risk of bleeding has been observed with coadministration of vitamin E and warfarin, with an increased PT due to the depletion of vitamin K–dependent clotting factors. This does not occur in healthy individuals with normal vitamin K levels. Increased gingival bleeding also was observed in patients taking vitamin E and aspirin.18 The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study showed that compared with placebo, alpha tocopherol at dosages of 50 mg/d increased the risk of fatal subarachnoid hemorrhage by 181% (95% CI, 37-479%; P =.01) in men aged 50-69 years who smoked cigarettes. The risk of cerebral infarction was decreased by 14% (95% CI, -25 to -1%, P =.03) in the vitamin E group, with no significant net effect of vitamin E on mortality from total strokes. These results had not been found in previous studies.19,20 Impaired immunity - An increased risk of sepsis occurred in a clinical trial (14% vs 6%) in which vitamin E was administered to premature neonates with a birthweight of less than 1500 g. When high-dose vitamin E of up to 30 mg/kg/d was administered to this population to prevent retrolental fibroplasia, necrotizing enterocolitis occurred. Incidence of necrotizing enterocolitis increased 2-fold (12%) in 2 studies; however, others have shown no difference. These findings may be secondary to the compounding effects of prematurity and the effect of vitamin E on the immune system. No other population has demonstrated these findings. Constitutional and GI effects - Fatigue and weakness were reported in 2 case series in which vitamin E was administered at dosages of 800 IU/d. The symptoms resolved with removal of the drug. Another study reported emotional disturbances in several women taking the same dosages. These symptoms have not been observed in other large series. Transient nausea and gastric distress have been observed in a few patients taking high dosages (2000-2500 IU/d) of vitamin E. Diarrhea and intestinal cramps have been reported at a dosage of 3200 IU/d. Other nonspecific, adverse effects of vitamin E, although reported only rarely, include fatigue, muscle weakness, delayed wound healing, and headache Multivitamins Do Not Reduce Risk for Lung Cancer, and Vitamin E May Raise It Sex Women taking vitamin E have reported emotional disturbances, but no other sex-related differences in incidence exist. Men who smoke have an increased risk of subarachnoid hemorrhage, as reported by one study.19 The risk of intracranial hemorrhage has not been studied in women. Age Premature infants with low birthweight have suffered life-threatening adverse effects from vitamin E, with sepsis and necrotizing enterocolitis have occurred in these, but not in other, infants. A syndrome of ascites, hepatomegaly, and thrombocytopenia resulting in death occurred in the 1980s in association with an intravenous vitamin E preparation used in premature infants with low birthweight. Presumably, the cause was a polysorbate carrier of the vitamin, and the syndrome has not occurred since its removal. Causes Hypervitaminosis E is caused by an excess intake of vitamin E supplements. Adverse effects usually are observed only at very high dosages, but 's meta-analysis showed a possible increase in mortality at dosages of 400 IU/d and higher.2 " Most studies of the safety of vitamin E supplementation have lasted for several months or less, so there is little evidence for the long-term safety of vitamin E supplementation. The Food and Nutrition Board of the Institute of Medicine Table 4: Tolerable Upper Intake Levels (UL) of vitamin E for Children and Adults [5] http://ods.od.nih.gov/factsheets/vitamine.asp#h7 In my opinion we as parents know our children better than anyone. I may be wrong but isn't reporting both good and bad signs how they come up with " possible " side effects? HPV Vaccine Linked To Teen's Paralysis? Her Father Thinks Gardasil Might Be; Drug's Maker Denies It Nov 14, 2007 http://www.cbsnews.com/stories/2008/07/07/earlyshow/health/main4236581.shtml And then less then a year later: HPV Vaccine Adverse Events Worrisome Says Key Investigator - Medscape Medical News Headlines Jul 26, 2008, 10:16 am July 26, 2008 — Serious neurologic, thromboembolic, and autoimmune complications have been reported in patients who received human papillomavirus (HPV) vaccines. Although not the norm, experts suggest that the events are grave enough to encourage caution. " The side effects that have been reported are real and they cannot be brushed aside, " Diane Harper, MD, from the Dartmouth Medical School, in Hanover, New Hampshire, told Medscape Oncology. Dr. Harper was a principal investigator of clinical HPV vaccine trials for both Merck and GlaxoKline. Here's just a few references to the myopathy risk of megadosage of vitamin E and a few other things I found. Acta Neuropathol (Berl). 1987 ;75 (2):166-72 2829497 (P,S,G,E, Necrotizing myopathy with paracrystalline inclusion bodies in hypervitaminosis E. A Bardosi, U Dickmann Department of Neuropathology, University of Göttingen, Federal Republic of Germany. A necrotizing, nonprogressive myopathy with unusual paracrystalline inclusion bodies is described in a patient who underwent long-term treatment with megadoses of vitamin E. The clinical course and morphological findings suggest a close relationship to the administration of the vitamin. The theoretical pathogenesis of muscle damage and the possible origin of paracrystalline inclusion bodies are discussed. Mesh-terms: Biopsy; Crystallization; Female; Human; Inclusion Bodies :: ultrastructure; Microscopy, Electron; Middle Aged; Muscles :: pathology; Muscles :: ultrastructure; Muscular Diseases :: pathology; Necrosis; Self Medication :: adverse effects; Support, Non- U.S. Gov't; Vitamin E :: adverse effects; Vitamin E :: metabolism; http://www.springerlink.com/content/x0nk77u3336n6560/ May want to read the following link but here's my summary: healthy woman supplementing megadoses of vitamin e for a total of SIX months developed dysphagia and myopathy within 3 months of supplementation -findings sugggest a close relationship to the administration of the vitamin e. http://resources.metapress.com/pdf-preview.axd? code=x0nk77u3336n6560 & size=larger From Neuroscience (hypervitaminosis E listed under necrotizing myopathy) http://obgyn.md.kku.ac.th/acadamic/Neurosciene30Nov.files/frame.htm#slide0049.ht\ \ m Encyclopaedia of Pediatric Neurology By C.P. Panteliadis, B.T. Darras page 804 under Table 39-2 hypervitaminosis E listed under " toxin induced myopathies " " necrotizing myopathy " Vitamin Tolerance of Animals (1987) HYPERVITAMINOSIS Vitamin E ... several studies have demonstrated adverse effects of very high levels of vitamin E in animals and humans Classification of Myopathies: By Pathologic Features Intoxication or poisoning Acute alcoholic rhabdomyolysis (Acute alcoholic myopathy) Cocaine Mushroom poisoning (Amanita phalloides) Snake venoms Hypervitaminosis E (Vitamin E intoxication) Organophosphates Others http://moon.ouhsc.edu/kfung/JTY1/NeuroHelp/ZNN0CL01.htm Myopathy can be traced to food, drink, drugs. (Check Electrolytes). Source: Internal Medicine News Publication Date: 01-APR-03 SNOWMASS, COLO. -- If you can get patients with myopathies to tell you everything they've been eating, drinking, or snorting, you'll identify the cause of the problem in many cases, Dr. L. Wortmann said at a symposium sponsored by the American College of Rheumatology. Any medication that increases or decreases concentrations of sodium. potassium, calcium, magnesium, or phosphorus can induce myopathic symptoms or, in severe cases, rhabdomyolysis, myoglobinuria, and renal failure.... Other myopathies can be traced to supplements taken to enhance athletic performance....Overdosing on vitamin E can cause a necrotizing myopathy, he said. Bone calcification was affected by excess vitamin E administered through the diet or by injection. It was concluded that excess vitamin E increased the requirement for vitamin D. Vitamin E at a dietary level of 2,200 IU/kg induced reticulocytosis and lowered hematocrit values. A lengthening of prothrombin time occurred when excess vitamin E was fed which was rapidly reversed by injection of vitamin K indicating an increased dietary requirement for vitamin K in the presence of excess vitamin E. The above findings suggest that excess vitamin E, like the other fat-soluble vitamins, must be considered as potentially toxic. http://jn.nutrition.org/cgi/content/abstract/103/3/371 Numerous reports have recently appeared in both the lay and medical press questioning the value of vitamin E supplementation and suggesting that there are risks associated with its use even at doses previously thought to have been " safe " . What do we do with the hundreds of studies and extensive clinical research that has been published in the medical literature suggesting benefit in cardiovascular disease, alzheimers, diabetes and other degenerative diseases? A search of the National Library of Medicine yields over www.ncbi.nlm.nih.gov/entrez/query.fcgi?dispmax=50 & db=PubMed & pmfilter_EDatLimit=N\ \ o+Limit & cmd_current=Limits & orig_db=PubMed & cmd=Search & term=vitamin+E+ & doptcmdl=Do\ \ cSum " target= " new " >25,000 citations, many funded or sponsored by the National Institutes of Health (NIH) and other prestigious medical and scientific organizations. This month, the authors of an article in Health News (Health News. 2005 Apr;11(4):12-3) headlined this statement: " High doses of vitamin E may increase risk of death. Talk to your doctor before taking supplements containing more than 200 IUs. " Discussing these questions with your doctor is very important. The purpose of this article is to provide you with a tool, a resource that you can print out and discuss with your physician. Negative Clinical Studies: Increased cancer recurrence in patients with head and neck cancer: Bairati and co-workers (J Natl Cancer Inst. 2005 Apr 6;97(7):481-8.) found in a multicenter, double-blind, placebo-controlled, randomized chemoprevention trial among 540 patients with head and neck cancer treated by radiation therapy that supplementation with alpha- tocopherol (400 IU/day) produced unexpected adverse effects on the occurrence of second primary cancers and on cancer-free survival. No increase in cancer risk, but increased risk of Heart Failure in patients with established vascular disease or diabetes: The HOPE Trial Investigators (JAMA. 2005 Mar 16;293(11):1338-47) evaluated whether long-term supplementation with vitamin E (Daily dose of natural source of 400 IU of vitamin E or matching placebo) decreases the risk of cancer, cancer death, and major cardiovascular events. The Hope vitamin E trial was a randomized, double-blind, placebo-controlled international trial of patients at least 55 years old with vascular disease or diabetes mellitus (9541 patients, in 174 centers) with a median duration of follow-up of 7.0 years. The investigators examined cancer incidence, cancer deaths, and major cardiovascular events (myocardial infarction, stroke, and cardiovascular death), heart failure, unstable angina, and need for cardiac revascularization. Among all HOPE patients, there were no significant differences in the primary analysis: for cancer incidence, 11.6% in the vitamin E group vs 12.3% in the placebo group developed cancer (a non-significant reduction for vitamin E); for cancer deaths, 3.3% in the vitamin E group vs 3.7% in placebo (also not significant) and for major cardiovascular events, 21.5% vs 20.6%, respectively (not significant). Of concern, was that patients in the vitamin E group had a significantly higher risk of heart failure and hospitalization for heart failure. The authors concluded that in patients with vascular disease or diabetes mellitus, long-term vitamin E supplementation does not prevent cancer or major cardiovascular events and may increase the risk for heart failure. Increased all-cause mortality: A meta-analysis of randomized, 19 controlled clinical trials (135,967 participants) evaluating the dose-response relationship between vitamin E supplementation and total mortality (Ann Intern Med. 2005 Jan 4;142(1):37-46. Epub 2004 Nov 10.) Published by and associates at the s Hopkins School of Medicine, found High-dosage (greater than or equal to 400 IU/d) vitamin E supplements may increase all-cause mortality by 5% and should be avoided. The Balanced Approach: Perhaps a reasonable approach would be a three-tiered effort: To moderately increase vitamin E levels with healthy dietary sources of the vitamin (which may allow for an equivalent level of 15-45 IUs per day from optimizing diet) The addition of MODERATE levels of supplementation with NATURAL (d- isomer) mixed tocopherols (which are closer to the mix seen in diet) and Use of minimum levels of vitamin E that have shown beneficial effect (100 IU or greater) and not exceeding levels which have been associated with risk (greater than 400 IU) and certainly not greater than 1,600 IUs where increased risk seems to be more clearly defined in some studies. Source: Ohio State University Extension Fact Sheet The 5-minute Neurology Consult By D. Joanne Lynn, Herbert B. Newton, Rae-Grant published in 2003 Painful toxic myopathies hypervitaminosis e http://books.google.com/books?id=Atuv8- rVXRoC & pg=PA300 & lpg=PA300 & dq=painful+toxic+myopathies+hypervitaminosis +e & source=web & ots=Hqxv9MMBut & sig=- oRWZe7zRMQL2774uf7b1c6uUf0 & hl=en & sa=X & oi=book_result & resnum=1 & ct=resul t Hypervitaminosis E is rare, but has been described in premature infants and those on oral anticoagulants. http://www.nmji.in/archives/volume%2016-4July%20August% 202003/Correspondance/Vitamin%20E%20levels.htm Posted 3/15/2005 8:48 PM Updated 3/16/2005 3:17 PM High-dose vitamin E gets more bad news By Liz Szabo, USA TODAY A study in today's Journal of the American Medical Association is the third in four months to question the health benefits of high-dose vitamin E supplements. In the study of nearly 4,000 patients, researchers found that megadoses had no effect on the risk of cardiovascular disease or cancer, but increased the risk of heart failure. While some doctors say vitamin E still has potential in preventing blindness and dementia, the study's authors say there is no reason for patients to take high doses. Multivitamins typically contain only 30 international units of vitamin E, but many individual supplements include 400 units or more. " There is this belief that you can take a miracle pill to prevent diseases like heart disease and cancer, but it's just not true, " says Eva Lonn, a leader of the study and a professor of medicine and cardiology at McMaster University in Ontario, Canada. " Unfortunately, we have to pay attention to our diet and exercise and our body weight. " Encouraging results from studies in the 1990s have helped make vitamin E the most popular supplement, taken by 22% of adults over 55, according an editorial by E. Greenberg of Dartmouth Medicine School published in January in ls of Internal Medicine. Nutritional supplements had estimated sales of $19 billion in 2003. In recent years, however, more rigorous clinical trials have failed to show that vitamin E protects the heart. Because this study is the first to suggest vitamin E may cause heart failure — a condition in which the heart muscle doesn't pump blood as it should — Lonn says doctors should conduct additional research to make sure that this connection was not just a coincidence. http://www.usatoday.com/news/health/2005-03-15-vitamin_x.htm some of the studies have found that in certain cases, antioxidants, including vitamin E, may actually increase the potential for developing heart disease, cancer and a host of other health problems. http://www.sciencedaily.com/releases/2006/03/060303110923.htm Hypervitaminosis E Weakness: Proximal Myalgia Serum CK: High Muscle Necrosis GT stain: Paranuclear accumulation of red granular material Inclusion staining pattern: NADH-TR, Acid phosphatase, Esterase http://neuromuscular.wustl.edu/nother/vitamin.htm ===== Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 14, 2009 Report Share Posted April 14, 2009 Wow!! I didnt mean to start such a debate or cause problems - I read on THIS site the miracles of vitamin E and now some of you are saying it caused seizures? I called our DAN Doctor before starting anything - in the article by that I read it said 3000 iu a day - our Dan suggested 1000 iu a day - the E we give is E oil with d-alpha tocopherol. 6 drops is 253 iu, we give a total of 24 drops - 12 in the morning and 12 at night. I was told that there are not any side effects from E - jsut that it can thin your blood - our son also takes Pro EFA - 1 tsp a day. The only negative side effect I have seen in the last week since starting it is a little constipation - but I contribute this to potty training - he has number 1 mastered but likes to hold in # 2. I will be definitely watching for any other strange or odd behavior - he is not having seizures, still sleeps well - eats well - very calm and talking!!!! Also with the oil - I have NO idea how much he is really getting as I mix it in his juice and when he is finished and I wash his cup there is some still in there with oil residue on the cup too. So is he getting the full 12 drops each serving - probably not. Just to be safe - I have another call into our DAN to see if there is anything strange I should be looking for. Thanks, Jill > > anyone that has their child on fish oils has their child on vitamin E to some extent. I know you believe it's the vitamin K that created all the issues but I did extensive searching on vitamin E after many of our children including my own had issues and learned more than I wanted to about hypervitaminosis. If you check the archives I posted a few of the rare stories of those who experimented with mega dosages of vitamin E and in a nutshell hypervitaminosis is vitamin poisening. > > My son is my height at 12 years old and had such a severe regression it took months to get him back -and it's documented not only by professionals but everyone at his school (they thought I had put him on some medication) It was horrific. In addition we still have the unknown with 's child Evoni. In my opinion there are far too many things out there that we know to be benign and effective to encourage parents to explore something that we already in this group found can cause severe side effects for unknown reasons. > > And PS -what is " mega dosage " for a 2 year old if 400 IUS of vitamin E is considered high dosage and " High-dosage (> or =400 IU/d) vitamin E supplements may increase all-cause mortality and should be avoided " ??? Evoni was only 2 years old. > > You want to know exactly how I feel ? I feel like I poisened my son -myself -and talk about guilt from that. No way am I letting anyone here talk about vitamin E without me sharing what I learned. Hey if you study the side effects and still wish to try it with your child in higher dosages than what they would get in their diet -or what is added in the fish oil capsules -then at least you are going in with open eyes. I wish someone warned me or this group prior to recommending vitamin E. Again it was me that found the hypervitaminosis information and reported it here -after my son and others had side effects and regressed. And by the way just like the fish oils worked within a few days for most of us -with this vitamin E in higher dosages the side effects were also in a few days -but unlike the fish oils they were to the extreme negative. And for my son and a few others -they didn't just go away once the supplement was stopped. And up to as recently as a month or so ago -just trying to give Tanner one capsule of 200 IUs of vitamin E he gets a headache -and the only time he ever got headaches was while > > Here's a bunch of info from the archives -can't read it all again so sorry if there are repeats -but hope you get the idea that yes it " could " be the vitamin E causing the issues. > > Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. > ER 3rd, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. > The s Hopkins School of Medicine, and The Welch Center for Prevention, Epidemiology and Clinical Research, The s Hopkins Medical Institutions, Baltimore, land 21205-2223, USA. ermiller@... > > CONCLUSION: High-dosage (> or =400 IU/d) vitamin E supplements may increase all-cause mortality and should be avoided. > http://www.ncbi.nlm.nih.gov/pubmed/15537682 > > Meta-analyses from and colleagues and from Bjelakovic and coauthors found that vitamin E supplementation increases all-cause mortality. These studies raised concerns on the long-term safety of high-dose vitamin E supplementation.2,10 > > > > Increased mortality - 's meta-analysis looked at dose-response relationships between vitamin E supplementation and total mortality.2 Nine out of 11 trials using high doses of vitamin E (400 IU or more) showed a significant increase in all-cause mortality in the vitamin E group. As the authors pointed out, however, the extent to which these findings can be generalized is unclear, because the high-dose trials were often small and were conducted on patients with chronic diseases.2 In Bjelakovic's meta-analysis, vitamin E, singly or combined with other antioxidants, was associated with a small but nonetheless significant (relative risk [RR], 1.04; 95% confidence interval [CI], 1.01-1.07) mortality increase.10 > Congestive heart failure - The Heart Outcomes Prevention Evaluation-The Ongoing Outcomes (HOPE-TOO) was a randomized trial examining the effects of 400 IU of vitamin E versus those of a placebo in patients with diabetes or vascular disease. After a mean 7.2 years of follow-up, vitamin E did not decrease the incidence of cancer deaths or vascular events, but evidence indicated that it did increase the incidence of heart failure (reference range, 1.19, P =.007).8,11,12,13,14,15,16,17 > Coagulopathy - An increased risk of bleeding has been observed with coadministration of vitamin E and warfarin, with an increased PT due to the depletion of vitamin K–dependent clotting factors. This does not occur in healthy individuals with normal vitamin K levels. Increased gingival bleeding also was observed in patients taking vitamin E and aspirin.18 The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study showed that compared with placebo, alpha tocopherol at dosages of 50 mg/d increased the risk of fatal subarachnoid hemorrhage by 181% (95% CI, 37-479%; P =.01) in men aged 50-69 years who smoked cigarettes. The risk of cerebral infarction was decreased by 14% (95% CI, -25 to -1%, P =.03) in the vitamin E group, with no significant net effect of vitamin E on mortality from total strokes. These results had not been found in previous studies.19,20 > Impaired immunity - An increased risk of sepsis occurred in a clinical trial (14% vs 6%) in which vitamin E was administered to premature neonates with a birthweight of less than 1500 g. When high-dose vitamin E of up to 30 mg/kg/d was administered to this population to prevent retrolental fibroplasia, necrotizing enterocolitis occurred. Incidence of necrotizing enterocolitis increased 2-fold (12%) in 2 studies; however, others have shown no difference. These findings may be secondary to the compounding effects of prematurity and the effect of vitamin E on the immune system. No other population has demonstrated these findings. > Constitutional and GI effects - Fatigue and weakness were reported in 2 case series in which vitamin E was administered at dosages of 800 IU/d. The symptoms resolved with removal of the drug. Another study reported emotional disturbances in several women taking the same dosages. These symptoms have not been observed in other large series. Transient nausea and gastric distress have been observed in a few patients taking high dosages (2000-2500 IU/d) of vitamin E. Diarrhea and intestinal cramps have been reported at a dosage of 3200 IU/d. Other nonspecific, adverse effects of vitamin E, although reported only rarely, include fatigue, muscle weakness, delayed wound healing, and headache > Multivitamins Do Not Reduce Risk for Lung Cancer, and Vitamin E May Raise It > Sex > Women taking vitamin E have reported emotional disturbances, but no other sex-related differences in incidence exist. > Men who smoke have an increased risk of subarachnoid hemorrhage, as reported by one study.19 The risk of intracranial hemorrhage has not been studied in women. > Age > Premature infants with low birthweight have suffered life-threatening adverse effects from vitamin E, with sepsis and necrotizing enterocolitis have occurred in these, but not in other, infants. > A syndrome of ascites, hepatomegaly, and thrombocytopenia resulting in death occurred in the 1980s in association with an intravenous vitamin E preparation used in premature infants with low birthweight. Presumably, the cause was a polysorbate carrier of the vitamin, and the syndrome has not occurred since its removal. > Causes > Hypervitaminosis E is caused by an excess intake of vitamin E supplements. > Adverse effects usually are observed only at very high dosages, but 's meta-analysis showed a possible increase in mortality at dosages of 400 IU/d and higher.2 > " Most studies of the safety of vitamin E supplementation have lasted for several > months or less, so there is little evidence for the long-term safety of vitamin > E supplementation. > The Food and Nutrition Board of the Institute of Medicine > > Table 4: Tolerable Upper Intake Levels (UL) of vitamin E for Children and Adults > [5] > http://ods.od.nih.gov/factsheets/vitamine.asp#h7 > > In my opinion we as parents know > our children better than anyone. I may be wrong but isn't reporting > both good and bad signs how they come up with " possible " side effects? > > HPV Vaccine Linked To Teen's Paralysis? > Her Father Thinks Gardasil Might Be; Drug's Maker Denies It > Nov 14, 2007 > http://www.cbsnews.com/stories/2008/07/07/earlyshow/health/main4236581.shtml > > And then less then a year later: > > HPV Vaccine Adverse Events Worrisome Says Key Investigator - Medscape > Medical News Headlines Jul 26, 2008, 10:16 am > July 26, 2008 — Serious neurologic, thromboembolic, and autoimmune > complications have been reported in patients who received human > papillomavirus (HPV) vaccines. Although not the norm, experts suggest > that the events are grave enough to encourage caution. " The side > effects that have been reported are real and they cannot be brushed > aside, " Diane Harper, MD, from the Dartmouth Medical School, in > Hanover, New Hampshire, told Medscape Oncology. Dr. Harper was a > principal investigator of clinical HPV vaccine trials for both Merck > and GlaxoKline. > > > Here's just a few references to the myopathy risk of megadosage of > vitamin E and a few other things I found. > > > Acta Neuropathol (Berl). 1987 ;75 (2):166-72 2829497 (P,S,G,E, > Necrotizing myopathy with paracrystalline inclusion bodies in > hypervitaminosis E. > A Bardosi, U Dickmann > Department of Neuropathology, University of Göttingen, Federal > Republic of Germany. > > A necrotizing, nonprogressive myopathy with unusual paracrystalline > inclusion bodies is described in a patient who underwent long-term > treatment with megadoses of vitamin E. The clinical course and > morphological findings suggest a close relationship to the > administration of the vitamin. The theoretical pathogenesis of muscle > damage and the possible origin of paracrystalline inclusion bodies > are discussed. > Mesh-terms: Biopsy; Crystallization; Female; Human; Inclusion > Bodies :: ultrastructure; Microscopy, Electron; Middle Aged; > Muscles :: pathology; Muscles :: ultrastructure; Muscular Diseases :: > pathology; Necrosis; Self Medication :: adverse effects; Support, Non- > U.S. Gov't; Vitamin E :: adverse effects; Vitamin E :: metabolism; > http://www.springerlink.com/content/x0nk77u3336n6560/ > > May want to read the following link but here's my summary: > healthy woman supplementing megadoses of vitamin e for a total of SIX > months developed dysphagia and myopathy within 3 months of > supplementation -findings sugggest a close relationship to the > administration of the vitamin e. > http://resources.metapress.com/pdf-preview.axd? > code=x0nk77u3336n6560 & size=larger > > From Neuroscience (hypervitaminosis E listed under necrotizing > myopathy) > http://obgyn.md.kku.ac.th/acadamic/Neurosciene30Nov.files/frame.htm#slide0049.ht\ \ > m > > > Encyclopaedia of Pediatric Neurology > By C.P. Panteliadis, B.T. Darras > page 804 under Table 39-2 > hypervitaminosis E listed under " toxin induced > myopathies " " necrotizing myopathy " > > > Vitamin Tolerance of Animals (1987) > HYPERVITAMINOSIS Vitamin E ... several studies have demonstrated > adverse effects of very high levels of vitamin E in animals and humans > > Classification of Myopathies: By Pathologic Features > > Intoxication or poisoning > > Acute alcoholic rhabdomyolysis (Acute alcoholic myopathy) > > Cocaine > > Mushroom poisoning (Amanita phalloides) > > Snake venoms > > Hypervitaminosis E (Vitamin E intoxication) > > Organophosphates > > Others > > http://moon.ouhsc.edu/kfung/JTY1/NeuroHelp/ZNN0CL01.htm > > Myopathy can be traced to food, drink, drugs. (Check Electrolytes). > > Source: Internal Medicine News > > Publication Date: 01-APR-03 > > > SNOWMASS, COLO. -- If you can get patients with myopathies to tell > you everything they've been eating, drinking, or snorting, you'll > identify the cause of the problem in many cases, Dr. L. > Wortmann said at a symposium sponsored by the American College of > Rheumatology. > > Any medication that increases or decreases concentrations of sodium. > potassium, calcium, magnesium, or phosphorus can induce myopathic > symptoms or, in severe cases, rhabdomyolysis, myoglobinuria, and > renal failure.... > > Other myopathies can be traced to supplements taken to enhance > athletic performance....Overdosing on vitamin E can cause a > necrotizing myopathy, he said. > > Bone calcification was affected by excess vitamin E administered > through the diet or by injection. It was concluded that excess > vitamin E increased the requirement for vitamin D. Vitamin E at a > dietary level of 2,200 IU/kg induced reticulocytosis and lowered > hematocrit values. A lengthening of prothrombin time occurred when > excess vitamin E was fed which was rapidly reversed by injection of > vitamin K indicating an increased dietary requirement for vitamin K > in the presence of excess vitamin E. The above findings suggest that > excess vitamin E, like the other fat-soluble vitamins, must be > considered as potentially toxic. > http://jn.nutrition.org/cgi/content/abstract/103/3/371 > > Numerous reports have recently appeared in both the lay and medical > press questioning the value of vitamin E supplementation and > suggesting that there are risks associated with its use even at doses > previously thought to have been " safe " . What do we do with the > hundreds of studies and extensive clinical research that has been > published in the medical literature suggesting benefit in > cardiovascular disease, alzheimers, diabetes and other degenerative > diseases? A search of the National Library of Medicine yields over > www.ncbi.nlm.nih.gov/entrez/query.fcgi?dispmax=50 & db=PubMed & pmfilter_EDatLimit=N\ \ > o+Limit & cmd_current=Limits & orig_db=PubMed & cmd=Search & term=vitamin+E+ & doptcmdl=Do\ \ > cSum " target= " new " >25,000 citations, many funded or sponsored by the > National Institutes of Health (NIH) and other prestigious medical and > scientific organizations. > > This month, the authors of an article in Health News (Health News. > 2005 Apr;11(4):12-3) headlined this statement: " High doses of vitamin > E may increase risk of death. Talk to your doctor before taking > supplements containing more than 200 IUs. " Discussing these questions > with your doctor is very important. The purpose of this article is to > provide you with a tool, a resource that you can print out and > discuss with your physician. > > Negative Clinical Studies: > > Increased cancer recurrence in patients with head and neck cancer: > > Bairati and co-workers (J Natl Cancer Inst. 2005 Apr 6;97(7):481-8.) > found in a multicenter, double-blind, placebo-controlled, randomized > chemoprevention trial among 540 patients with head and neck cancer > treated by radiation therapy that supplementation with alpha- > tocopherol (400 IU/day) produced unexpected adverse effects on the > occurrence of second primary cancers and on cancer-free survival. > > No increase in cancer risk, but increased risk of Heart Failure in > patients with established vascular disease or diabetes: > > The HOPE Trial Investigators (JAMA. 2005 Mar 16;293(11):1338-47) > evaluated whether long-term supplementation with vitamin E (Daily > dose of natural source of 400 IU of vitamin E or matching placebo) > decreases the risk of cancer, cancer death, and major cardiovascular > events. The Hope vitamin E trial was a randomized, double-blind, > placebo-controlled international trial of patients at least 55 years > old with vascular disease or diabetes mellitus (9541 patients, in 174 > centers) with a median duration of follow-up of 7.0 years. The > investigators examined cancer incidence, cancer deaths, and major > cardiovascular events (myocardial infarction, stroke, and > cardiovascular death), heart failure, unstable angina, and need for > cardiac revascularization. Among all HOPE patients, there were no > significant differences in the primary analysis: for cancer > incidence, 11.6% in the vitamin E group vs 12.3% in the placebo group > developed cancer (a non-significant reduction for vitamin E); for > cancer deaths, 3.3% in the vitamin E group vs 3.7% in placebo (also > not significant) and for major cardiovascular events, 21.5% vs 20.6%, > respectively (not significant). Of concern, was that patients in the > vitamin E group had a significantly higher risk of heart failure and > hospitalization for heart failure. The authors concluded that in > patients with vascular disease or diabetes mellitus, long-term > vitamin E supplementation does not prevent cancer or major > cardiovascular events and may increase the risk for heart failure. > > Increased all-cause mortality: > > A meta-analysis of randomized, 19 controlled clinical trials (135,967 > participants) evaluating the dose-response relationship between > vitamin E supplementation and total mortality (Ann Intern Med. 2005 > Jan 4;142(1):37-46. Epub 2004 Nov 10.) Published by and > associates at the s Hopkins School of Medicine, found High-dosage > (greater than or equal to 400 IU/d) vitamin E supplements may > increase all-cause mortality by 5% and should be avoided. > > The Balanced Approach: > > Perhaps a reasonable approach would be a three-tiered effort: > > To moderately increase vitamin E levels with healthy dietary sources > of the vitamin (which may allow for an equivalent level of 15-45 IUs > per day from optimizing diet) > > The addition of MODERATE levels of supplementation with NATURAL (d- > isomer) mixed tocopherols (which are closer to the mix seen in diet) > and > > Use of minimum levels of vitamin E that have shown beneficial effect > (100 IU or greater) and not exceeding levels which have been > associated with risk (greater than 400 IU) and certainly not greater > than 1,600 IUs where increased risk seems to be more clearly defined > in some studies. > Source: Ohio State University Extension Fact Sheet > > > The 5-minute Neurology Consult By D. Joanne Lynn, Herbert B. Newton, > Rae-Grant published in 2003 > > Painful toxic myopathies hypervitaminosis e > > http://books.google.com/books?id=Atuv8- > rVXRoC & pg=PA300 & lpg=PA300 & dq=painful+toxic+myopathies+hypervitaminosis > +e & source=web & ots=Hqxv9MMBut & sig=- > oRWZe7zRMQL2774uf7b1c6uUf0 & hl=en & sa=X & oi=book_result & resnum=1 & ct=resul > t > > > Hypervitaminosis E is rare, but has been described in premature > infants and those on oral anticoagulants. > http://www.nmji.in/archives/volume%2016-4July%20August% > 202003/Correspondance/Vitamin%20E%20levels.htm > > Posted 3/15/2005 8:48 PM Updated 3/16/2005 3:17 PM > High-dose vitamin E gets more bad news > By Liz Szabo, USA TODAY > A study in today's Journal of the American Medical Association is the > third in four months to question the health benefits of high-dose > vitamin E supplements. > In the study of nearly 4,000 patients, researchers found that > megadoses had no effect on the risk of cardiovascular disease or > cancer, but increased the risk of heart failure. > > While some doctors say vitamin E still has potential in preventing > blindness and dementia, the study's authors say there is no reason > for patients to take high doses. > > Multivitamins typically contain only 30 international units of > vitamin E, but many individual supplements include 400 units or more. > > " There is this belief that you can take a miracle pill to prevent > diseases like heart disease and cancer, but it's just not true, " says > Eva Lonn, a leader of the study and a professor of medicine and > cardiology at McMaster University in Ontario, Canada. " Unfortunately, > we have to pay attention to our diet and exercise and our body > weight. " > > Encouraging results from studies in the 1990s have helped make > vitamin E the most popular supplement, taken by 22% of adults over > 55, according an editorial by E. Greenberg of Dartmouth > Medicine School published in January in ls of Internal Medicine. > Nutritional supplements had estimated sales of $19 billion in 2003. > > In recent years, however, more rigorous clinical trials have failed > to show that vitamin E protects the heart. > > Because this study is the first to suggest vitamin E may cause heart > failure — a condition in which the heart muscle doesn't pump blood as > it should — Lonn says doctors should conduct additional research to > make sure that this connection was not just a coincidence. > http://www.usatoday.com/news/health/2005-03-15-vitamin_x.htm > > some of the studies have found that in certain cases, antioxidants, > including vitamin E, may actually increase the potential for > developing heart disease, cancer and a host of other health problems. > http://www.sciencedaily.com/releases/2006/03/060303110923.htm > > > Hypervitaminosis E > Weakness: Proximal > Myalgia > Serum CK: High > Muscle > Necrosis > GT stain: Paranuclear accumulation of red granular material > Inclusion staining pattern: NADH-TR, Acid phosphatase, Esterase > http://neuromuscular.wustl.edu/nother/vitamin.htm > > ===== > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 14, 2009 Report Share Posted April 14, 2009 -Jill, I think it is Vitamin K and not Vitamin E causing the seizures. Vitamin K in high doses is in the speak formula. -- In , " jilltracy74 " <jilltracy74@...> wrote: > > Wow!! I didnt mean to start such a debate or cause problems - I read on THIS site the miracles of vitamin E and now some of you are saying it caused seizures? > > I called our DAN Doctor before starting anything - in the article by that I read it said 3000 iu a day - our Dan suggested 1000 iu a day - the E we give is E oil with d-alpha tocopherol. 6 drops is 253 iu, we give a total of 24 drops - 12 in the morning and 12 at night. > > I was told that there are not any side effects from E - jsut that it can thin your blood - our son also takes Pro EFA - 1 tsp a day. > > The only negative side effect I have seen in the last week since starting it is a little constipation - but I contribute this to potty training - he has number 1 mastered but likes to hold in # 2. > > I will be definitely watching for any other strange or odd behavior - he is not having seizures, still sleeps well - eats well - very calm and talking!!!! > > Also with the oil - I have NO idea how much he is really getting as I mix it in his juice and when he is finished and I wash his cup there is some still in there with oil residue on the cup too. So is he getting the full 12 drops each serving - probably not. > > Just to be safe - I have another call into our DAN to see if there is anything strange I should be looking for. > > Thanks, Jill > > > > > > anyone that has their child on fish oils has their child on vitamin E to some extent. I know you believe it's the vitamin K that created all the issues but I did extensive searching on vitamin E after many of our children including my own had issues and learned more than I wanted to about hypervitaminosis. If you check the archives I posted a few of the rare stories of those who experimented with mega dosages of vitamin E and in a nutshell hypervitaminosis is vitamin poisening. > > > > My son is my height at 12 years old and had such a severe regression it took months to get him back -and it's documented not only by professionals but everyone at his school (they thought I had put him on some medication) It was horrific. In addition we still have the unknown with 's child Evoni. In my opinion there are far too many things out there that we know to be benign and effective to encourage parents to explore something that we already in this group found can cause severe side effects for unknown reasons. > > > > And PS -what is " mega dosage " for a 2 year old if 400 IUS of vitamin E is considered high dosage and " High-dosage (> or =400 IU/d) vitamin E supplements may increase all-cause mortality and should be avoided " ??? Evoni was only 2 years old. > > > > You want to know exactly how I feel ? I feel like I poisened my son -myself -and talk about guilt from that. No way am I letting anyone here talk about vitamin E without me sharing what I learned. Hey if you study the side effects and still wish to try it with your child in higher dosages than what they would get in their diet -or what is added in the fish oil capsules -then at least you are going in with open eyes. I wish someone warned me or this group prior to recommending vitamin E. Again it was me that found the hypervitaminosis information and reported it here -after my son and others had side effects and regressed. And by the way just like the fish oils worked within a few days for most of us -with this vitamin E in higher dosages the side effects were also in a few days -but unlike the fish oils they were to the extreme negative. And for my son and a few others -they didn't just go away once the supplement was stopped. And up to as recently as a month or so ago -just trying to give Tanner one capsule of 200 IUs of vitamin E he gets a headache -and the only time he ever got headaches was while > > > > Here's a bunch of info from the archives -can't read it all again so sorry if there are repeats -but hope you get the idea that yes it " could " be the vitamin E causing the issues. > > > > Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. > > ER 3rd, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E. > > The s Hopkins School of Medicine, and The Welch Center for Prevention, Epidemiology and Clinical Research, The s Hopkins Medical Institutions, Baltimore, land 21205-2223, USA. ermiller@ > > > > CONCLUSION: High-dosage (> or =400 IU/d) vitamin E supplements may increase all-cause mortality and should be avoided. > > http://www.ncbi.nlm.nih.gov/pubmed/15537682 > > > > Meta-analyses from and colleagues and from Bjelakovic and coauthors found that vitamin E supplementation increases all-cause mortality. These studies raised concerns on the long-term safety of high-dose vitamin E supplementation.2,10 > > > > > > > > Increased mortality - 's meta-analysis looked at dose-response relationships between vitamin E supplementation and total mortality.2 Nine out of 11 trials using high doses of vitamin E (400 IU or more) showed a significant increase in all-cause mortality in the vitamin E group. As the authors pointed out, however, the extent to which these findings can be generalized is unclear, because the high-dose trials were often small and were conducted on patients with chronic diseases.2 In Bjelakovic's meta-analysis, vitamin E, singly or combined with other antioxidants, was associated with a small but nonetheless significant (relative risk [RR], 1.04; 95% confidence interval [CI], 1.01-1.07) mortality increase.10 > > Congestive heart failure - The Heart Outcomes Prevention Evaluation-The Ongoing Outcomes (HOPE-TOO) was a randomized trial examining the effects of 400 IU of vitamin E versus those of a placebo in patients with diabetes or vascular disease. After a mean 7.2 years of follow-up, vitamin E did not decrease the incidence of cancer deaths or vascular events, but evidence indicated that it did increase the incidence of heart failure (reference range, 1.19, P =.007).8,11,12,13,14,15,16,17 > > Coagulopathy - An increased risk of bleeding has been observed with coadministration of vitamin E and warfarin, with an increased PT due to the depletion of vitamin K–dependent clotting factors. This does not occur in healthy individuals with normal vitamin K levels. Increased gingival bleeding also was observed in patients taking vitamin E and aspirin.18 The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study showed that compared with placebo, alpha tocopherol at dosages of 50 mg/d increased the risk of fatal subarachnoid hemorrhage by 181% (95% CI, 37-479%; P =.01) in men aged 50-69 years who smoked cigarettes. The risk of cerebral infarction was decreased by 14% (95% CI, -25 to -1%, P =.03) in the vitamin E group, with no significant net effect of vitamin E on mortality from total strokes. These results had not been found in previous studies.19,20 > > Impaired immunity - An increased risk of sepsis occurred in a clinical trial (14% vs 6%) in which vitamin E was administered to premature neonates with a birthweight of less than 1500 g. When high-dose vitamin E of up to 30 mg/kg/d was administered to this population to prevent retrolental fibroplasia, necrotizing enterocolitis occurred. Incidence of necrotizing enterocolitis increased 2-fold (12%) in 2 studies; however, others have shown no difference. These findings may be secondary to the compounding effects of prematurity and the effect of vitamin E on the immune system. No other population has demonstrated these findings. > > Constitutional and GI effects - Fatigue and weakness were reported in 2 case series in which vitamin E was administered at dosages of 800 IU/d. The symptoms resolved with removal of the drug. Another study reported emotional disturbances in several women taking the same dosages. These symptoms have not been observed in other large series. Transient nausea and gastric distress have been observed in a few patients taking high dosages (2000-2500 IU/d) of vitamin E. Diarrhea and intestinal cramps have been reported at a dosage of 3200 IU/d. Other nonspecific, adverse effects of vitamin E, although reported only rarely, include fatigue, muscle weakness, delayed wound healing, and headache > > Multivitamins Do Not Reduce Risk for Lung Cancer, and Vitamin E May Raise It > > Sex > > Women taking vitamin E have reported emotional disturbances, but no other sex-related differences in incidence exist. > > Men who smoke have an increased risk of subarachnoid hemorrhage, as reported by one study.19 The risk of intracranial hemorrhage has not been studied in women. > > Age > > Premature infants with low birthweight have suffered life-threatening adverse effects from vitamin E, with sepsis and necrotizing enterocolitis have occurred in these, but not in other, infants. > > A syndrome of ascites, hepatomegaly, and thrombocytopenia resulting in death occurred in the 1980s in association with an intravenous vitamin E preparation used in premature infants with low birthweight. Presumably, the cause was a polysorbate carrier of the vitamin, and the syndrome has not occurred since its removal. > > Causes > > Hypervitaminosis E is caused by an excess intake of vitamin E supplements. > > Adverse effects usually are observed only at very high dosages, but 's meta-analysis showed a possible increase in mortality at dosages of 400 IU/d and higher.2 > > " Most studies of the safety of vitamin E supplementation have lasted for several > > months or less, so there is little evidence for the long-term safety of vitamin > > E supplementation. > > The Food and Nutrition Board of the Institute of Medicine > > > > Table 4: Tolerable Upper Intake Levels (UL) of vitamin E for Children and Adults > > [5] > > http://ods.od.nih.gov/factsheets/vitamine.asp#h7 > > > > In my opinion we as parents know > > our children better than anyone. I may be wrong but isn't reporting > > both good and bad signs how they come up with " possible " side effects? > > > > HPV Vaccine Linked To Teen's Paralysis? > > Her Father Thinks Gardasil Might Be; Drug's Maker Denies It > > Nov 14, 2007 > > http://www.cbsnews.com/stories/2008/07/07/earlyshow/health/main4236581.shtml > > > > And then less then a year later: > > > > HPV Vaccine Adverse Events Worrisome Says Key Investigator - Medscape > > Medical News Headlines Jul 26, 2008, 10:16 am > > July 26, 2008 — Serious neurologic, thromboembolic, and autoimmune > > complications have been reported in patients who received human > > papillomavirus (HPV) vaccines. Although not the norm, experts suggest > > that the events are grave enough to encourage caution. " The side > > effects that have been reported are real and they cannot be brushed > > aside, " Diane Harper, MD, from the Dartmouth Medical School, in > > Hanover, New Hampshire, told Medscape Oncology. Dr. Harper was a > > principal investigator of clinical HPV vaccine trials for both Merck > > and GlaxoKline. > > > > > > Here's just a few references to the myopathy risk of megadosage of > > vitamin E and a few other things I found. > > > > > > Acta Neuropathol (Berl). 1987 ;75 (2):166-72 2829497 (P,S,G,E, > > Necrotizing myopathy with paracrystalline inclusion bodies in > > hypervitaminosis E. > > A Bardosi, U Dickmann > > Department of Neuropathology, University of Göttingen, Federal > > Republic of Germany. > > > > A necrotizing, nonprogressive myopathy with unusual paracrystalline > > inclusion bodies is described in a patient who underwent long-term > > treatment with megadoses of vitamin E. The clinical course and > > morphological findings suggest a close relationship to the > > administration of the vitamin. The theoretical pathogenesis of muscle > > damage and the possible origin of paracrystalline inclusion bodies > > are discussed. > > Mesh-terms: Biopsy; Crystallization; Female; Human; Inclusion > > Bodies :: ultrastructure; Microscopy, Electron; Middle Aged; > > Muscles :: pathology; Muscles :: ultrastructure; Muscular Diseases :: > > pathology; Necrosis; Self Medication :: adverse effects; Support, Non- > > U.S. Gov't; Vitamin E :: adverse effects; Vitamin E :: metabolism; > > http://www.springerlink.com/content/x0nk77u3336n6560/ > > > > May want to read the following link but here's my summary: > > healthy woman supplementing megadoses of vitamin e for a total of SIX > > months developed dysphagia and myopathy within 3 months of > > supplementation -findings sugggest a close relationship to the > > administration of the vitamin e. > > http://resources.metapress.com/pdf-preview.axd? > > code=x0nk77u3336n6560 & size=larger > > > > From Neuroscience (hypervitaminosis E listed under necrotizing > > myopathy) > > http://obgyn.md.kku.ac.th/acadamic/Neurosciene30Nov.files/frame.htm#slide0049.ht\ \ > > m > > > > > > Encyclopaedia of Pediatric Neurology > > By C.P. Panteliadis, B.T. Darras > > page 804 under Table 39-2 > > hypervitaminosis E listed under " toxin induced > > myopathies " " necrotizing myopathy " > > > > > > Vitamin Tolerance of Animals (1987) > > HYPERVITAMINOSIS Vitamin E ... several studies have demonstrated > > adverse effects of very high levels of vitamin E in animals and humans > > > > Classification of Myopathies: By Pathologic Features > > > > Intoxication or poisoning > > > > Acute alcoholic rhabdomyolysis (Acute alcoholic myopathy) > > > > Cocaine > > > > Mushroom poisoning (Amanita phalloides) > > > > Snake venoms > > > > Hypervitaminosis E (Vitamin E intoxication) > > > > Organophosphates > > > > Others > > > > http://moon.ouhsc.edu/kfung/JTY1/NeuroHelp/ZNN0CL01.htm > > > > Myopathy can be traced to food, drink, drugs. (Check Electrolytes). > > > > Source: Internal Medicine News > > > > Publication Date: 01-APR-03 > > > > > > SNOWMASS, COLO. -- If you can get patients with myopathies to tell > > you everything they've been eating, drinking, or snorting, you'll > > identify the cause of the problem in many cases, Dr. L. > > Wortmann said at a symposium sponsored by the American College of > > Rheumatology. > > > > Any medication that increases or decreases concentrations of sodium. > > potassium, calcium, magnesium, or phosphorus can induce myopathic > > symptoms or, in severe cases, rhabdomyolysis, myoglobinuria, and > > renal failure.... > > > > Other myopathies can be traced to supplements taken to enhance > > athletic performance....Overdosing on vitamin E can cause a > > necrotizing myopathy, he said. > > > > Bone calcification was affected by excess vitamin E administered > > through the diet or by injection. It was concluded that excess > > vitamin E increased the requirement for vitamin D. Vitamin E at a > > dietary level of 2,200 IU/kg induced reticulocytosis and lowered > > hematocrit values. A lengthening of prothrombin time occurred when > > excess vitamin E was fed which was rapidly reversed by injection of > > vitamin K indicating an increased dietary requirement for vitamin K > > in the presence of excess vitamin E. The above findings suggest that > > excess vitamin E, like the other fat-soluble vitamins, must be > > considered as potentially toxic. > > http://jn.nutrition.org/cgi/content/abstract/103/3/371 > > > > Numerous reports have recently appeared in both the lay and medical > > press questioning the value of vitamin E supplementation and > > suggesting that there are risks associated with its use even at doses > > previously thought to have been " safe " . What do we do with the > > hundreds of studies and extensive clinical research that has been > > published in the medical literature suggesting benefit in > > cardiovascular disease, alzheimers, diabetes and other degenerative > > diseases? A search of the National Library of Medicine yields over > > www.ncbi.nlm.nih.gov/entrez/query.fcgi?dispmax=50 & db=PubMed & pmfilter_EDatLimit=N\ \ > > o+Limit & cmd_current=Limits & orig_db=PubMed & cmd=Search & term=vitamin+E+ & doptcmdl=Do\ \ > > cSum " target= " new " >25,000 citations, many funded or sponsored by the > > National Institutes of Health (NIH) and other prestigious medical and > > scientific organizations. > > > > This month, the authors of an article in Health News (Health News. > > 2005 Apr;11(4):12-3) headlined this statement: " High doses of vitamin > > E may increase risk of death. Talk to your doctor before taking > > supplements containing more than 200 IUs. " Discussing these questions > > with your doctor is very important. The purpose of this article is to > > provide you with a tool, a resource that you can print out and > > discuss with your physician. > > > > Negative Clinical Studies: > > > > Increased cancer recurrence in patients with head and neck cancer: > > > > Bairati and co-workers (J Natl Cancer Inst. 2005 Apr 6;97(7):481-8.) > > found in a multicenter, double-blind, placebo-controlled, randomized > > chemoprevention trial among 540 patients with head and neck cancer > > treated by radiation therapy that supplementation with alpha- > > tocopherol (400 IU/day) produced unexpected adverse effects on the > > occurrence of second primary cancers and on cancer-free survival. > > > > No increase in cancer risk, but increased risk of Heart Failure in > > patients with established vascular disease or diabetes: > > > > The HOPE Trial Investigators (JAMA. 2005 Mar 16;293(11):1338-47) > > evaluated whether long-term supplementation with vitamin E (Daily > > dose of natural source of 400 IU of vitamin E or matching placebo) > > decreases the risk of cancer, cancer death, and major cardiovascular > > events. The Hope vitamin E trial was a randomized, double-blind, > > placebo-controlled international trial of patients at least 55 years > > old with vascular disease or diabetes mellitus (9541 patients, in 174 > > centers) with a median duration of follow-up of 7.0 years. The > > investigators examined cancer incidence, cancer deaths, and major > > cardiovascular events (myocardial infarction, stroke, and > > cardiovascular death), heart failure, unstable angina, and need for > > cardiac revascularization. Among all HOPE patients, there were no > > significant differences in the primary analysis: for cancer > > incidence, 11.6% in the vitamin E group vs 12.3% in the placebo group > > developed cancer (a non-significant reduction for vitamin E); for > > cancer deaths, 3.3% in the vitamin E group vs 3.7% in placebo (also > > not significant) and for major cardiovascular events, 21.5% vs 20.6%, > > respectively (not significant). Of concern, was that patients in the > > vitamin E group had a significantly higher risk of heart failure and > > hospitalization for heart failure. The authors concluded that in > > patients with vascular disease or diabetes mellitus, long-term > > vitamin E supplementation does not prevent cancer or major > > cardiovascular events and may increase the risk for heart failure. > > > > Increased all-cause mortality: > > > > A meta-analysis of randomized, 19 controlled clinical trials (135,967 > > participants) evaluating the dose-response relationship between > > vitamin E supplementation and total mortality (Ann Intern Med. 2005 > > Jan 4;142(1):37-46. Epub 2004 Nov 10.) Published by and > > associates at the s Hopkins School of Medicine, found High-dosage > > (greater than or equal to 400 IU/d) vitamin E supplements may > > increase all-cause mortality by 5% and should be avoided. > > > > The Balanced Approach: > > > > Perhaps a reasonable approach would be a three-tiered effort: > > > > To moderately increase vitamin E levels with healthy dietary sources > > of the vitamin (which may allow for an equivalent level of 15-45 IUs > > per day from optimizing diet) > > > > The addition of MODERATE levels of supplementation with NATURAL (d- > > isomer) mixed tocopherols (which are closer to the mix seen in diet) > > and > > > > Use of minimum levels of vitamin E that have shown beneficial effect > > (100 IU or greater) and not exceeding levels which have been > > associated with risk (greater than 400 IU) and certainly not greater > > than 1,600 IUs where increased risk seems to be more clearly defined > > in some studies. > > Source: Ohio State University Extension Fact Sheet > > > > > > The 5-minute Neurology Consult By D. Joanne Lynn, Herbert B. Newton, > > Rae-Grant published in 2003 > > > > Painful toxic myopathies hypervitaminosis e > > > > http://books.google.com/books?id=Atuv8- > > rVXRoC & pg=PA300 & lpg=PA300 & dq=painful+toxic+myopathies+hypervitaminosis > > +e & source=web & ots=Hqxv9MMBut & sig=- > > oRWZe7zRMQL2774uf7b1c6uUf0 & hl=en & sa=X & oi=book_result & resnum=1 & ct=resul > > t > > > > > > Hypervitaminosis E is rare, but has been described in premature > > infants and those on oral anticoagulants. > > http://www.nmji.in/archives/volume%2016-4July%20August% > > 202003/Correspondance/Vitamin%20E%20levels.htm > > > > Posted 3/15/2005 8:48 PM Updated 3/16/2005 3:17 PM > > High-dose vitamin E gets more bad news > > By Liz Szabo, USA TODAY > > A study in today's Journal of the American Medical Association is the > > third in four months to question the health benefits of high-dose > > vitamin E supplements. > > In the study of nearly 4,000 patients, researchers found that > > megadoses had no effect on the risk of cardiovascular disease or > > cancer, but increased the risk of heart failure. > > > > While some doctors say vitamin E still has potential in preventing > > blindness and dementia, the study's authors say there is no reason > > for patients to take high doses. > > > > Multivitamins typically contain only 30 international units of > > vitamin E, but many individual supplements include 400 units or more. > > > > " There is this belief that you can take a miracle pill to prevent > > diseases like heart disease and cancer, but it's just not true, " says > > Eva Lonn, a leader of the study and a professor of medicine and > > cardiology at McMaster University in Ontario, Canada. " Unfortunately, > > we have to pay attention to our diet and exercise and our body > > weight. " > > > > Encouraging results from studies in the 1990s have helped make > > vitamin E the most popular supplement, taken by 22% of adults over > > 55, according an editorial by E. Greenberg of Dartmouth > > Medicine School published in January in ls of Internal Medicine. > > Nutritional supplements had estimated sales of $19 billion in 2003. > > > > In recent years, however, more rigorous clinical trials have failed > > to show that vitamin E protects the heart. > > > > Because this study is the first to suggest vitamin E may cause heart > > failure — a condition in which the heart muscle doesn't pump blood as > > it should — Lonn says doctors should conduct additional research to > > make sure that this connection was not just a coincidence. > > http://www.usatoday.com/news/health/2005-03-15-vitamin_x.htm > > > > some of the studies have found that in certain cases, antioxidants, > > including vitamin E, may actually increase the potential for > > developing heart disease, cancer and a host of other health problems. > > http://www.sciencedaily.com/releases/2006/03/060303110923.htm > > > > > > Hypervitaminosis E > > Weakness: Proximal > > Myalgia > > Serum CK: High > > Muscle > > Necrosis > > GT stain: Paranuclear accumulation of red granular material > > Inclusion staining pattern: NADH-TR, Acid phosphatase, Esterase > > http://neuromuscular.wustl.edu/nother/vitamin.htm > > > > ===== > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 14, 2009 Report Share Posted April 14, 2009 I don't think it's a debate or problem- it's just that new people don't know what this group has been through for the past few years. I mean this group has been around for over a decade but vitamin e has only been a hot topic really for a few years. Prior to that vitamin E came up because some parents didn't want soy -some complained (!) when Nordic raised the vitamin E in each ProEFA capsule from 8 IUs to 15 IUs because of the research that showed supplementation with fish oil over time can create a vitamin E deficiency. could be correct about the seizures being from the vitamin K but it's just her opinion and she could also be wrong. As far as any professional I've spoken to (and of course I called many of the researchers behind the studies) there are so many unknowns. Besides -as far as I know Tanner never had a seizure -but he had many other side effects including the headaches and most noticeable to all -severe and dramatic regressions in speech back to groping where he opened his mouth and nothing at all came out. It was a nightmare. On smaller amounts of vitamin E at the time many of us too were very excited about surges we saw in sensory and in speech -but that again could have to do with the fact that this group in one where we put our children on fish oils and it is now known that mere supplementation of fish oils over a period of time can create a deficiency. Does that mean that we need high dosages? Does that mean we need to supplement for a few days, weeks, months and then stop? Nobody knows. All I'm trying to point out is that it's an unknown road and in the history of this group one that we still have not reached the bottom of yet. Until Evoni is resolved there are a few of us that just want to point out to be aware that there many be risks that some medical doctors don't know about- which is why I posted the medical reports I did. I tried to tell everyone that this group was using a 1/1 ratio of alpha to gamma for the most part- and most only were using 200/200 capsules because if you check the archives that was what I was using and posted about. I'm sure means well -but like the experts she would be limited by the research out there- and in regards to children with mega dosages of vitamin E -even vitamin E alone -there is little. I also can tell you that knowing what I do now about vitamin E after reading the reports I no longer feel comfortable with any dosage that would in any way be considered high. I'm sure what you are using -100 IUs is not considered high -but you need to keep in mind there is vitamin E in the fish oil and any other foods or vitamins to keep track of fat soluble vitamins. I can tell you that without vitamin K my son Tanner regressed when I tried him on higher dosages of alpha over the gamma. Check the archives as it's all there. And I tried that three times. Tanner needed a 1/1 ratio. There were exceptions to the rule where perhaps fish oils didn't work for them and vitamin E did. Three kids like that? Four? Out of thousands? To me based on what I saw the best thing would be to start with the basics -the fish oil...and go from there slowly. But at least all of you get to know there could be side effects and will know what to look for. When my son Tanner started vomiting and had severe diarrhea- I just thought it was something he ate. When he complained of headaches I couldn't imagine why. When he begged me for an aspirin I didn't realize that could be dangerous based on everything else. When he would then sleep for hours and hours -through dinner...I and nobody else knows what happened to my son Tanner. All I know is that I had to re teach him even basics sounds that he had known since 3 years old- even the sound " b " You see...I didn't take the regression seriously because if you stop the fish oils or use the wrong formula most of our children regress. No biggie -you put them back on the right formula of fish oils and poof they are back to normal. That's what we thought would happen -including my son Tanner. Tanner was a HUGE fan of vitamin E too -and he wanted to keep trying it. It broke his little heart as well. Don't believe everything you read here or anywhere. It's your child...I typically never let my guard down to just take advice from anyone -even a professional I trust -without question. I don't know why I did with this one...but like most I thought -it's vitamin E -it's healthy. It probably still is- in moderation. And is wheat germ vitamin E healthier as Jane asked -I don't know. ===== Quote Link to comment Share on other sites More sharing options...
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