Curcumin

[Guest guest]

From: " Dana Herbert " <herbertdana@...>

> Has anyone had any success with curcumin??

haven't personally used it, but am a very strong believer in it.

Here's the info I've compiled:

turmeric (main active ingredient curcumin) -- 1 of the top

cancer-healing herbs; 2-4 g or 2 tsp turmeric; I've seen 10g

recommended for melanoma; or 6-8 grams of curcumin (Gammill, 10/04);

curcumin's synergistic w/genistein (soy), green tea, & bromelain;

curcumin's especially effective w/estrogenic breast cancer, myeloma,

colon and perhaps also prostate (particularly in high dosage)

(www.herbalfields.com/c7.html) cancer, and (in dose dependent manner)

chronic myeloid leukemia; curcumin's a COX-2 inhibitor,

antiinflammatory, antioxidant, antifungal, anti-angiogenic, induces

apoptosis, enhances immunity; curcumin's not very bioavailable, but

taking it w/piperine makes it more 2000% bioavailable; curcumin

vaseline was effective (and reduced pain) w/squamous cell and

ulcerating oral cancers; use good brand (e.g., New Chapter, Zyflamend,

Source Naturals); " curcumin can be hard on your gut " ; " curcumin

inhibited camptothecin-, mechlorethamine-, and doxorubicin-induced

apoptosis of...breast cancer cells "

www.cancerres.aacrjournals.org/cgi/content/abstract/62/13/3868

" Curcumin....can diminish the usefulness of certain...drugs. "

(Gammill, 10/12/03)

" While curcumin is a SAPK inhibitor it does...things...beneficial

during chemo...lowers NF-kappaB...an important factor in drug

resistance [MDR]...At least...with doxorubicin, 5-FU, cisplatin and

Paclitaxel....curcumin [made] myeloma...more sensitive

to...Vincristine and melphalan....reduced drug resistance to

Vincristine [in other types of cancer]....increased the effect

doxorubicin, 5-FU and Paclitaxel in a dose dependent manner [in]

prostate cancer....reduced...resistance to cisplatin [for]

fibrosarcoma...elevated liver enzymes normalized....drug resistance in

ovarian cancer...reduced....reduce IL-6....cancer cells resistant

to doxorubicin were sensitized...after treatment with curcumin.

I...encourage its use with prostate, ovarian and maybe other cancers.

[May enhance effects of] Cisplatin, 5-FU, Vincristine and

Paclitaxel....may be best used to sensitize cancer cells before chemo

is begun " www.denvernaturopathic.com (Curcumin Update #2 12/14/03)

www.lef.org/magazine/mag2002/jul2002_report_curcumin_01.html

www.turmeric-curcumin.com

[Guest guest]

Leonard,

The link you referenced did not work

www.cancerres.aacrjournals.org/cgi/content/abstract/62/13/3868

Is it correct?

Thank you for the info.

Dolores

-------------- Original message --------------

>

> From: " Dana Herbert "

> > Has anyone had any success with curcumin??

> haven't personally used it, but am a very strong believer in it.

> Here's the info I've compiled:

>

> turmeric (main active ingredient curcumin) -- 1 of the top

> cancer-healing herbs; 2-4 g or 2 tsp turmeric; I've seen 10g

> recommended for melanoma; or 6-8 grams of curcumin (Gammill, 10/04);

> curcumin's synergistic w/genistein (soy), green tea, & bromelain;

> curcumin's especially effective w/estrogenic breast cancer, myeloma,

> colon and perhaps also prostate (particularly in high dosage)

> (www.herbalfields.com/c7.html) cancer, and (in dose dependent manner)

> chronic myeloid leukemia; curcumin's a COX-2 inhibitor,

> antiinflammatory, antioxidant, antifungal, anti-angiogenic, induces

> apoptosis, enhances immunity; curcumin's not very bioavailable, but

> taking it w/piperine makes it more 2000% bioavailable; curcumin

> vaseline was effective (and reduced pain) w/squamous cell and

> ulcerating oral cancers; use good brand (e.g., New Chapter, Zyflamend,

> Source Naturals); " curcumin can be hard on your gut " ; " curcumin

> inhibited camptothecin-, mechlorethamine-, and doxorubicin-induced

> apoptosis of...breast cancer cells "

> www.cancerres.aacrjournals.org/cgi/content/abstract/62/13/3868

> " Curcumin....can diminish the usefulness of certain...drugs. "

> (Gammill, 10/12/03)

> " While curcumin is a SAPK inhibitor it does...things...beneficial

> during chemo...lowers NF-kappaB...an important factor in drug

> resistance [MDR]...At least...with doxorubicin, 5-FU, cisplatin and

> Paclitaxel....curcumin [made] myeloma...more sensitive

> to...Vincristine and melphalan....reduced drug resistance to

> Vincristine [in other types of cancer]....increased the effect

> doxorubicin, 5-FU and Paclitaxel in a dose dependent manner [in]

> prostate cancer....reduced...resistance to cisplatin [for]

> fibrosarcoma...elevated liver enzymes normalized....drug resistance in

> ovarian cancer...reduced....reduce IL-6....cancer cells resistant

> to doxorubicin were sensitized...after treatment with curcumin.

> I...encourage its use with prostate, ovarian and maybe other cancers.

> [May enhance effects of] Cisplatin, 5-FU, Vincristine and

> Paclitaxel....may be best used to sensitize cancer cells before chemo

> is begun " www.denvernaturopathic.com (Curcumin Update #2 12/14/03)

> www.lef.org/magazine/mag2002/jul2002_report_curcumin_01.html

> www.turmeric-curcumin.com

>

>

>

>

>

>

>

[Guest guest]

From: <delrio@...>

> The link you referenced did not work

> www.cancerres.aacrjournals.org/cgi/content/abstract/62/13/3868 > Is

it correct?

No. Sorry.

You might try searching the journal(s) at

http://cancerres.aacrjournals.org/contents-by-date.0.shtml

Let me know if you find the correct website.

[Guest guest]

,

Curcumin is the active ingredient in the spice turmeric (which my

little girl is allergic to). Have you tried turmeric with him? You

could try turmeric and see. If no allergy to turmeric, then it could

be the shell or coloring (not to forget that the supplement is more

concentrated). I personally prefer the spice over curcumin

supplement.

I hope that helps

Samar

>

> Greetings all:

>

> Curcumin was recommended to us by our doc as a natural

> anti-inflammatory. We gave one dose, and his cheeks went bright red

> (this has happened in the past, mainly as a response to particular

> foods). Has anyone else had this response to curcumin? This is a

> gelcap, so it could simply be artificial coloring of the shell

(I'll

> try washing it off next time).

>

> I'd be interested in hearing about the experiences of others to this

> supplement, both positive and negative.

>

> cheers,

>

[Guest guest]

Sounds like a phenol reaction to me...

in MD

[ ] Curcumin

> Greetings all:

>

> Curcumin was recommended to us by our doc as a natural

> anti-inflammatory. We gave one dose, and his cheeks went bright red

> (this has happened in the past, mainly as a response to particular

> foods). Has anyone else had this response to curcumin? This is a

> gelcap, so it could simply be artificial coloring of the shell (I'll

> try washing it off next time).

>

> I'd be interested in hearing about the experiences of others to this

> supplement, both positive and negative.

>

> cheers,

>

>

>

> =======================================================

>

[Guest guest]

Curcumin does many things. One is that it greatly elevates cysteine levels, and

thus it will

cause a 'sulfur food' reaction in sensitive people.

It is also spicy and can cause flushing just like eating chili peppers does.

Andy

> >

> > Curcumin was recommended to us by our doc as a natural

> > anti-inflammatory. We gave one dose, and his cheeks went bright red

> > (this has happened in the past, mainly as a response to particular

> > foods). Has anyone else had this response to curcumin? This is a

> > gelcap, so it could simply be artificial coloring of the shell (I'll

> > try washing it off next time).

> >

> > I'd be interested in hearing about the experiences of others to this

> > supplement, both positive and negative.

> >

> > cheers,

> >

> >

> >

> >

=======================================================

> >

[Guest guest]

Are Curcumin and Tumeric the same thing? If so, giving Tumeric caused our

little one's eyes to blacken in about two days, she's not phenolic sensitive.

If they're different things then disregard :-)

[ ] Curcumin

> Greetings all:

>

> Curcumin was recommended to us by our doc as a natural

> anti-inflammatory. We gave one dose, and his cheeks went bright red

> (this has happened in the past, mainly as a response to particular

> foods). Has anyone else had this response to curcumin? This is a

> gelcap, so it could simply be artificial coloring of the shell (I'll

> try washing it off next time).

>

> I'd be interested in hearing about the experiences of others to this

> supplement, both positive and negative.

>

> cheers,

>

>

>

> =======================================================

>

[Guest guest]

Curcumin is an extract of turmeric and is the active compound in it for most of

its effects.

Andy

[Guest guest]

Well, I give my whole family Turmeric. At first, they had orange poops, and

my children are allergic to orange foods. But after a month, their poops

turned back to brown. I figured since Turmeric is an antibacterial, it will

kill bacteria even if it isn't digested. They are more symptom-free, and they

have adjusted to it. Note that curcumin is made from Turmeric. I heard they

make a white Turmeric, but I don't know anything about it. Note also that I

give a digestive enzyme at the same time I give the Turmeric.

Heidi N

************************************** See what's new at http://www.aol.com

[Guest guest]

I absolutely LOVE Curcumin - my GS takes one capsule a day div. 3 x daily.

Careful though I have ruined many clothes, if you have to open the capsules

- curcumin stains and does not come out!

chris

_____

From: [mailto: ]

On Behalf Of l.largey

Sent: Friday, December 07, 2007 10:47 AM

Subject: [ ] curcumin

Just wanted to share i have been looking into this herb and it seems to

have many great properties for helping with digestion, immune sytem,

and an ant-inflamatory. It's also believed to help detox free radicals.

Here is one sight I found that has some info on it. My son is taking a

product now that has curcumin and milk thistle.

http://www.herbalex <http://www.herbalextractsplus.com/curcumin.cfm>

tractsplus.com/curcumin.cfm

[Guest guest]

Curcumin in the treatment of pain, diabetic neuropathy and Alzheimer’s Disease

 

Background: Curcumin, the pigment found in the spice turmeric (Curcuma longa)

has been known to demonstrate a number of interesting, beneficial effects.

Curcumin has been demonstrated to be an anti-inflammatory agent, an

anti-oxidant, anti-angiogenic, anti-bacterial, anti-neoplastic (2,4) and it has

been demonstrated to be effective in the prevention and treatment of

Alzheimer’s Disease.(3)

Curcumin has been demonstrated to inhibit cyclooxygenase-2, lipooxygenase,

nuclear factor kappa-B and inducible nitric oxide sythase.

In addition to effects on inflammatory pathways, Curcumin has an independent

effect on endogenous opiate pathways, as well. That is, Curcumin is a primary

pain reliever involved in the same pathways as are opiates.(1)

The addition of curcumin, a natural COX-2 inhibitor, to other

anti-inflammatories synergistically (up to 1000%) augments the growth inhibitory

effects in in-vitro and in-vivo models of arthritis and cancer, thus rendering

effective action of the drug. Decreased dosages of 1/10th can be

demonstrated.(4)

Curcumin has been demonstrated to be effective in the treatment of auto-immune

processes, as well. Curcumin is beneficial in the treatment of autoimmune

diseases by inhibiting a number of proteans and enzymes, such as cytokines

IL-1beta, IL-6, IL-12, TNF-alpha, IFN-gamma and associated JAK-STAT, AP-1, and

NF-kappaB signaling pathways in immune regulatory cells. (5)

For diabetic neuropathy, the use of Curcumin indicates anti-nociceptive, that is

pain relieving activity and point towards the beneficial effects with insulin in

attenuating diabetic neuropathic pain, possibly through the participation of NO

and TNF-alpha.(6) The effects on diabetic pain seem to take up to 4 weeks, but

may be observed much more rapidly.

Recommendations:

1. For the treatment of auto-immune disorders, pharmaceutical grade Curcumin

should be used in dosages of 500 mg twice or three times daily. The purest form

of Curcumin must be used.

2. For pain, Curcumin 500 mg can be used twice daily.

3. For the treatment and/or prevention of Alzhemier’s Disease, 500 mg once or

twice daily can be used.

4. For the treatment of diabetic neuropathy, Curcumin 500 mg should be taken

twice daily; the addition of alpha lipoic acid 250 mg, three to four times daily

provides the best relief.

References:

Tajik H, Tamaddonfard E, et al: The effect of curcumin (active substance of

turmeric) on the acetic acid-induced visceral nociception in rats.  Pak J Biol

Sci. Jan 15;11(2):312-4, 2008.

Tajik H, Tammadonfard E, et al: Interaction between Curcumin and Opiod system in

the formalin test of rats. Pak J Biol Sci. 10(15): 2583-2586, 2007.

Anand P, Sundaram C, et al: Curcumin and cancer: an “old-age†disease with

an “age-old solution. Cancer Lett: 18:267(1)133-64, 2008.

Lev-Ari S, Lichtenbert D, Arber N: Compositions for treatment of cancer and

inflammation. Recent Patents Anticancer Drug Discov. (1):55-62, 2008.

Bright JJ: Curcumin and autoimmune disease. Adv Exp Med Biol 595:425-51, 2007.

Sharma S, Chopra K, Kulkarni SK: Effect of insulin and its combination with

resveratrol or Curcumin in attenuation of diabetic neuropathic pain:

participation of nitric oxide and TNF-alpha. Phytother Res 21(3):278-83, 2007.

Love, Gabby. :0)

http://stemcellforautism.blogspot.com/

 

" I know of nobody who is purely Autistic or purely neurotypical. Even God had

some Autistic moments, which is why the planets all spin. " ~ Jerry Newport