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Jill the good news is good to hear as always. But as I said in my last message

to you - again you only had your child on the fish oils alone for a week or so

prior to adding the extreme dosage of vitamin E. How do you know what's

creating the surges?

I'm thrilled that your child has not experienced any side effects yet. Please

be aware for your precious child's sake that in the medical cases I posted for

you the last time the myopathy that develops from too much vitamin e happened in

months in adults- and increased death rate was from just 400 IUs in various

individuals in the meta analysis I posted. From what I posted from the experts

you are giving your child over 3 times upper tolerable level of vitamin e which

would only be appropriate if your child had some very rare severe metabolic

disorder or under the care of a medical specialist in this area.

Why not make sure your child even needs all this vitamin e? Why not give it a

try with just the fish oils alone for...I don't know a month or two? Why not

try stopping the vitamin E and not the fish oils and let us know if you still

see the surges that (again) if you check the archives -even recent ones (today?)

we all see on the fish oils alone. You could have your child on the right

formula of fish oils and for example feeding him twinkies and seeing surges

right now -but of course you wouldn't credit the twinkie would you? To me

what's really sad is that I used that example as an extreme but a twinkie a day

'may' be healthier than 1000 IUs of vitamin E a day for a child. I'd check with

a neurodevelopmental medical doctor with a background in pediatrics and get

their opinion. Why take any chance with your child?

And again -my son Tanner regressed 2 times prior to being on speak on just

vitamin E alone when I raised the alpha over the gamma -it's all in the

archives. Also..I wouldn't be so quick to assume that all the severe side

effects reported in this group were from vitamin k. As Clint Eastwood so

famously says you feeling lucky? To me vitamin e in mega dosages is taking a

chance. Again why take any chance with your own precious child? Especially

when for most -for thousands -for over a decade now -the right formula of fish

oils alone work. And they worked for the person's child that even started this

(IMO) mess with vitamin e in our group -check the archives.

=====

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Very good advice!!! In most cases that I've heard of it has been the

fish oil that produced the surges. With Vit. E or any other vitamin

that could be toxic at high levels, it is best to heed on the side of

caution. You can only know where the benefit has come from if you

have tried each separately. Best to start with the fish oils. I've

heard of too many negative outcomes with high levels of Vit. E. If

you wish to add in some E, I'd only do it in small doses and under

the guidance of your child's pediatrician.

Jill - Another Jill, not the OP.

>

> Jill the good news is good to hear as always. But as I said in my

last message to you - again you only had your child on the fish oils

alone for a week or so prior to adding the extreme dosage of vitamin

E. How do you know what's creating the surges?

>

> I'm thrilled that your child has not experienced any side effects

yet. Please be aware for your precious child's sake that in the

medical cases I posted for you the last time the myopathy that

develops from too much vitamin e happened in months in adults- and

increased death rate was from just 400 IUs in various individuals in

the meta analysis I posted. From what I posted from the experts you

are giving your child over 3 times upper tolerable level of vitamin e

which would only be appropriate if your child had some very rare

severe metabolic disorder or under the care of a medical specialist

in this area.

>

>

> Why not make sure your child even needs all this vitamin e? Why

not give it a try with just the fish oils alone for...I don't know a

month or two? Why not try stopping the vitamin E and not the fish

oils and let us know if you still see the surges that (again) if you

check the archives -even recent ones (today?) we all see on the fish

oils alone. You could have your child on the right formula of fish

oils and for example feeding him twinkies and seeing surges right

now -but of course you wouldn't credit the twinkie would you? To me

what's really sad is that I used that example as an extreme but a

twinkie a day 'may' be healthier than 1000 IUs of vitamin E a day for

a child. I'd check with a neurodevelopmental medical doctor with a

background in pediatrics and get their opinion. Why take any chance

with your child?

>

> And again -my son Tanner regressed 2 times prior to being on speak

on just vitamin E alone when I raised the alpha over the gamma -it's

all in the archives. Also..I wouldn't be so quick to assume that all

the severe side effects reported in this group were from vitamin k.

As Clint Eastwood so famously says you feeling lucky? To me

vitamin e in mega dosages is taking a chance. Again why take any

chance with your own precious child? Especially when for most -for

thousands -for over a decade now -the right formula of fish oils

alone work. And they worked for the person's child that even started

this (IMO) mess with vitamin e in our group -check the archives.

>

> =====

>

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I'm just curious. Did your Dan Dr. give your child a blood test to see if he was

low in vit e or did he just tell you to add it. What brand do you use and how

much. My daughter is almost 3 and weighs about 35 lbs. She is on 2 efas and 1

epa that we just added almost 3 weeks. Since we added the epa she seems spacey

and it seems like she has a harder time staying focused (something that was

never an issue) Thanks for the info.

-------------- Original message from " jilltracy74 " <jilltracy74@...>:

--------------

Hi Everyone

I wanted to post a positive update about my son and the Vitamin E supplements we

started about a month ago.

I know this caused some controversy last time - but I think that was more with

the Vit E and Vit K that caused some regression with others kids - we just added

Vit E oil drops 1000 iu a day per our DAN's recommendation.

We have continued to see amazing growth in Chase. He is 3 1/2 and oficially

diagnosed with SPD/SID and apraxia. He is very social has good eye contact - but

has lots of problems with transitons and continuing the flow of conversation.

Since the Vit E drops we have seen a language explosion - he is prob at about

100 words a day now, he has expanded on his words - sentences. Ex: for the

longest time when he would want something he would grunt - then he would say

" go " then he would say " come " He used " come " for a very long time - and since

the Vit E oil he now comes up to me or whoever he wants help from " come with me

please " then I will get up and he will say " thank you " - we also get a lot of " I

love you " out of the clear blue - when he looks at us and smiles :)

The BIGGEST change that I am thrilled about is he has started to finally answer

our questions. Most of the time I get a " NO " but he is acknowledging me and

giving me an answer. Example: " Chase do you have to go Potty? " " NO! " or he will

say " pee pee pee pee " and run in and go. He has even started to run in from

playing outside and yell " pee pee " and I say ok let's go - and he says " help me "

and we go - yay!!!! and always when he's done " yay we did it " or " way to go " ....

He still cannot frequently answer questions like " do you want a red cup or blue

cup? " every now and then he will say the color red or blue but most of the time

he will point and yell " this one " - so we are just at the beginning stages of

having him start to answer questions.

One of the funniest things I have heard him say since the Vit E drops is he will

come upon his sister playing something and say to her " incredible " - Incredible

- where the heck did that come from? LOL....his overall demeanor is a lot more

calm - his circles are gone from under his eyes and he is for the most part

listening a lot better.

I have to add that this along with his other DAN protocol (GFCF) really seems to

be helping him - he has some impulse control issues and his attention can

sometimes not be the greatest - but my NT daughter is classic ADHD - Im just

wondering if this is what he truly has?? Only time will tell as he gets older.

We still have a long way to go - but were on our way!!!

Thanks for letting me share!

Jill

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Hi

Thanks again for responding- Chase has actually been on fish oils for a year -

Pro EFA for about 5 months. The Vit E has only been in the last month. It is

Vit E Oil drops - 1000 iu a day. It is e-oil antioxidant protection d-alpha

tocopherol - our DAN said he needed to have the tocopherol in it - is this what

Tanner used?

I have called our DAN doctor about 5 times regarding this b/c Im scared its too

much and he continues to reassure me that it is not.

I think we might give it a try of stopping the vit e for a couple weeks,

continue with all other biomed and pro efa's and then see what happens.

but really the only changes in his diet/biomed was adding the vit e - and then

the language surge we are now seeing.

He is actually commenting on everything we do and see - adding to conversations

and saying new words I never ever heard before!

His dark circles are gone from under his eyes too.

Do you think the DAN is ok'ing the 1000 iu b/c it is oil drops and there is

never any real way to know how much you actually consume?? - b/c I always see

residue left in his sippy cups.

Thanks, Jill

>

> Jill the good news is good to hear as always. But as I said in my last

message to you - again you only had your child on the fish oils alone for a week

or so prior to adding the extreme dosage of vitamin E. How do you know what's

creating the surges?

>

> I'm thrilled that your child has not experienced any side effects yet. Please

be aware for your precious child's sake that in the medical cases I posted for

you the last time the myopathy that develops from too much vitamin e happened in

months in adults- and increased death rate was from just 400 IUs in various

individuals in the meta analysis I posted. From what I posted from the experts

you are giving your child over 3 times upper tolerable level of vitamin e which

would only be appropriate if your child had some very rare severe metabolic

disorder or under the care of a medical specialist in this area.

>

>

> Why not make sure your child even needs all this vitamin e? Why not give it a

try with just the fish oils alone for...I don't know a month or two? Why not

try stopping the vitamin E and not the fish oils and let us know if you still

see the surges that (again) if you check the archives -even recent ones (today?)

we all see on the fish oils alone. You could have your child on the right

formula of fish oils and for example feeding him twinkies and seeing surges

right now -but of course you wouldn't credit the twinkie would you? To me

what's really sad is that I used that example as an extreme but a twinkie a day

'may' be healthier than 1000 IUs of vitamin E a day for a child. I'd check with

a neurodevelopmental medical doctor with a background in pediatrics and get

their opinion. Why take any chance with your child?

>

> And again -my son Tanner regressed 2 times prior to being on speak on just

vitamin E alone when I raised the alpha over the gamma -it's all in the

archives. Also..I wouldn't be so quick to assume that all the severe side

effects reported in this group were from vitamin k. As Clint Eastwood so

famously says you feeling lucky? To me vitamin e in mega dosages is taking a

chance. Again why take any chance with your own precious child? Especially

when for most -for thousands -for over a decade now -the right formula of fish

oils alone work. And they worked for the person's child that even started this

(IMO) mess with vitamin e in our group -check the archives.

>

> =====

>

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I read from the archives here about vit e helping late talkers- I asked our dan

about it - he researched it, and advised 1000 iu daily. no he did not do a

blood test, he is a family doctor and has been a DAN for over 10 years.

I just left him another message regarding this megadosing - part of me is scared

it is going to hurt him, but a huge part of me - is " HEY its working!!! "

In the article I read it talked about 3000 iu a day and he said that was way too

much and to do 1000.

He is 3 1/2 and weighs 40 lbs.

Talk to your doctor first!

Thanks, Jill

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Jill,

My son is a great responder too even though he didn't test low for vitamin E.

Just get your DAN! to check the clotting factors in a couple of months and make

sure everything is ok.

We still have major problems with the attention. Yeast treatments help alot.

Have you performed an OAT (organic acid test)? These will confirm whether you

have gut dybiosis. Also, MB12 shots coupled with folinic acid and DMG helped

greatly with his speech too. I've actually been able to decrease the E with no

regression for the first time ever.

>

> Hi Everyone

>

> I wanted to post a positive update about my son and the Vitamin E supplements

we started about a month ago.

>

> I know this caused some controversy last time - but I think that was more with

the Vit E and Vit K that caused some regression with others kids - we just added

Vit E oil drops 1000 iu a day per our DAN's recommendation.

>

> We have continued to see amazing growth in Chase. He is 3 1/2 and oficially

diagnosed with SPD/SID and apraxia. He is very social has good eye contact -

but has lots of problems with transitons and continuing the flow of

conversation.

>

> Since the Vit E drops we have seen a language explosion - he is prob at about

100 words a day now, he has expanded on his words - sentences. Ex: for the

longest time when he would want something he would grunt - then he would say

" go " then he would say " come " He used " come " for a very long time - and since

the Vit E oil he now comes up to me or whoever he wants help from " come with me

please " then I will get up and he will say " thank you " - we also get a lot of " I

love you " out of the clear blue - when he looks at us and smiles :)

>

> The BIGGEST change that I am thrilled about is he has started to finally

answer our questions. Most of the time I get a " NO " but he is acknowledging me

and giving me an answer. Example: " Chase do you have to go Potty? " " NO! " or he

will say " pee pee pee pee " and run in and go. He has even started to run in

from playing outside and yell " pee pee " and I say ok let's go - and he says

" help me " and we go - yay!!!! and always when he's done " yay we did it " or " way

to go " ....

>

> He still cannot frequently answer questions like " do you want a red cup or

blue cup? " every now and then he will say the color red or blue but most of the

time he will point and yell " this one " - so we are just at the beginning stages

of having him start to answer questions.

>

> One of the funniest things I have heard him say since the Vit E drops is he

will come upon his sister playing something and say to her " incredible " -

Incredible - where the heck did that come from? LOL....his overall demeanor is

a lot more calm - his circles are gone from under his eyes and he is for the

most part listening a lot better.

>

> I have to add that this along with his other DAN protocol (GFCF) really seems

to be helping him - he has some impulse control issues and his attention can

sometimes not be the greatest - but my NT daughter is classic ADHD - Im just

wondering if this is what he truly has?? Only time will tell as he gets older.

We still have a long way to go - but were on our way!!!

>

> Thanks for letting me share!

>

> Jill

>

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thanks cathy

we are currently treating yeast overgrowth with a small daily dose of diflucan-

we saw a huge change in him behavior wise just from treating the yeast

we try to be as GFCFYF as possible - I will check into the clotting test and oat

test - he was not severe in any one area except for speech so maybe that is why

our dan never ran every test

we currently take diflucan, multi chewable, probiotics 2x daily, digestive

enzymes, all natural lithium salt, vit e oil, and pro efa. this is the combo

that seems to have worked best for him.

we tried the mb12 spray and didnt see real results - so we discontinued.

our next dan appt is next month - and I want to address his obvious adhd - its

hard at 3 though - a lot could be the age too...

Jill :)

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Hi ,

Wasn't that vitamin e study with the 400 IU's done on very sick and mostly

elderly people? Or is it another study? Just wondering, I just took my boys

off the vitamin E (I had been doing 400 IUs for a while now) and will see

what happens, I'd feel better not having to give it to them and am just

hoping I see no difference!

cathy

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Hi !

Please do update us; based on reports so far you should be fine as long as you

keep up with the right fish oils.

About the meta analysis...most of the studies were older sick people -but not

all the studies were. Think the mean age was 40 to 80 or something For sure

from memory at least one of the studies I recall was woman probably around our

age who were on 400 IUs -and all cause mortality meaning the deaths were not all

the same reason -but just a higher than normal death rate. Kind of creepy to

read. As it says here " CONCLUSION: High-dosage (> or =400 IU/d) vitamin E

supplements may increase all-cause mortality and should be avoided. "

http://www.ncbi.nlm.nih.gov/pubmed/15537682

Don't want to read it all again but know it's out there if one wanted to look.

Here's the meta analysis

http://www.annals.org/cgi/content/full/0000605-200501040-00110v1 and below is an

archive. I know there are tons of other archives on this but honestly I'm over

it with vitamin E. In small amounts or when needed by some in higher amounts I

don't have a problem with it -but for me vitamin E is like when the lifeguard

yells " rip tide get out of the water " I'm out.

Anyway here's the archive:

Acta Neuropathol (Berl). 1987 ;75 (2):166-72 2829497 (P,S,G,E,B)

Necrotizing myopathy with paracrystalline inclusion bodies in

hypervitaminosis E.

A Bardosi, U Dickmann

Department of Neuropathology, University of Göttingen, Federal

Republic of Germany.

A necrotizing, nonprogressive myopathy with unusual paracrystalline

inclusion bodies is described in a patient who underwent long-term

treatment with megadoses of vitamin E. The clinical course and

morphological findings suggest a close relationship to the

administration of the vitamin. The theoretical pathogenesis of muscle

damage and the possible origin of paracrystalline inclusion bodies

are discussed.

Mesh-terms: Biopsy; Crystallization; Female; Human; Inclusion

Bodies :: ultrastructure; Microscopy, Electron; Middle Aged;

Muscles :: pathology; Muscles :: ultrastructure; Muscular Diseases ::

pathology; Necrosis; Self Medication :: adverse effects; Support, Non-

U.S. Gov't; Vitamin E :: adverse effects; Vitamin E :: metabolism;

http://www.springerlink.com/content/x0nk77u3336n6560/

May want to read the following link but here's my summary:

healthy woman supplementing megadoses of vitamin e for a total of SIX

months developed dysphagia and myopathy within 3 months of

supplementation -findings sugggest a close relationship to the

administration of the vitamin e.

http://resources.metapress.com/pdf-preview.axd?

code=x0nk77u3336n6560 & size=larger

From Neuroscience (hypervitaminosis E listed under necrotizing

myopathy)

http://obgyn.md.kku.ac.th/acadamic/Neurosciene30Nov.files/frame.htm#slide0049.ht\

\

m

Encyclopaedia of Pediatric Neurology

By C.P. Panteliadis, B.T. Darras

page 804 under Table 39-2

hypervitaminosis E listed under " toxin induced

myopathies " " necrotizing myopathy "

Vitamin Tolerance of Animals (1987)

HYPERVITAMINOSIS Vitamin E ... several studies have demonstrated

adverse effects of very high levels of vitamin E in animals and humans

Classification of Myopathies: By Pathologic Features

Intoxication or poisoning

Acute alcoholic rhabdomyolysis (Acute alcoholic myopathy)

Cocaine

Mushroom poisoning (Amanita phalloides)

Snake venoms

Hypervitaminosis E (Vitamin E intoxication)

Organophosphates

Others

http://moon.ouhsc.edu/kfung/JTY1/NeuroHelp/ZNN0CL01.htm

" Most studies of the safety of vitamin E supplementation have lasted

for several months or less, so there is little evidence for the long-

term safety of vitamin E supplementation.

The Food and Nutrition Board of the Institute of Medicine

Table 4: Tolerable Upper Intake Levels (UL) of vitamin E for Children

and Adults [5]

http://ods.od.nih.gov/factsheets/vitamine.asp#h7

Myopathy can be traced to food, drink, drugs. (Check Electrolytes).

Source: Internal Medicine News

Publication Date: 01-APR-03

SNOWMASS, COLO. -- If you can get patients with myopathies to tell

you everything they've been eating, drinking, or snorting, you'll

identify the cause of the problem in many cases, Dr. L.

Wortmann said at a symposium sponsored by the American College of

Rheumatology.

Any medication that increases or decreases concentrations of sodium.

potassium, calcium, magnesium, or phosphorus can induce myopathic

symptoms or, in severe cases, rhabdomyolysis, myoglobinuria, and

renal failure....

Other myopathies can be traced to supplements taken to enhance

athletic performance....Overdosing on vitamin E can cause a

necrotizing myopathy, he said.

Bone calcification was affected by excess vitamin E administered

through the diet or by injection. It was concluded that excess

vitamin E increased the requirement for vitamin D. Vitamin E at a

dietary level of 2,200 IU/kg induced reticulocytosis and lowered

hematocrit values. A lengthening of prothrombin time occurred when

excess vitamin E was fed which was rapidly reversed by injection of

vitamin K indicating an increased dietary requirement for vitamin K

in the presence of excess vitamin E. The above findings suggest that

excess vitamin E, like the other fat-soluble vitamins, must be

considered as potentially toxic.

http://jn.nutrition.org/cgi/content/abstract/103/3/371

Numerous reports have recently appeared in both the lay and medical

press questioning the value of vitamin E supplementation and

suggesting that there are risks associated with its use even at doses

previously thought to have been " safe " . What do we do with the

hundreds of studies and extensive clinical research that has been

published in the medical literature suggesting benefit in

cardiovascular disease, alzheimers, diabetes and other degenerative

diseases? A search of the National Library of Medicine yields over

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?dispmax=50 & db=PubMed & pmfilter_EDat\

\

Limit=No+Limit & cmd_current=Limits & orig_db=PubMed & cmd=Search & term=vitamin+E+ & dopt\

\

cmdl=Do\cSum " target= " new " >25,000 citations, many funded or sponsored by the

National Institutes of Health (NIH) and other prestigious medical and

scientific organizations.

This month, the authors of an article in Health News (Health News.

2005 Apr;11(4):12-3) headlined this statement: " High doses of vitamin

E may increase risk of death. Talk to your doctor before taking

supplements containing more than 200 IUs. " Discussing these questions

with your doctor is very important. The purpose of this article is to

provide you with a tool, a resource that you can print out and

discuss with your physician.

Negative Clinical Studies:

Increased cancer recurrence in patients with head and neck cancer:

Bairati and co-workers (J Natl Cancer Inst. 2005 Apr 6;97(7):481-8.)

found in a multicenter, double-blind, placebo-controlled, randomized

chemoprevention trial among 540 patients with head and neck cancer

treated by radiation therapy that supplementation with alpha-

tocopherol (400 IU/day) produced unexpected adverse effects on the

occurrence of second primary cancers and on cancer-free survival.

No increase in cancer risk, but increased risk of Heart Failure in

patients with established vascular disease or diabetes:

The HOPE Trial Investigators (JAMA. 2005 Mar 16;293(11):1338-47)

evaluated whether long-term supplementation with vitamin E (Daily

dose of natural source of 400 IU of vitamin E or matching placebo)

decreases the risk of cancer, cancer death, and major cardiovascular

events. The Hope vitamin E trial was a randomized, double-blind,

placebo-controlled international trial of patients at least 55 years

old with vascular disease or diabetes mellitus (9541 patients, in 174

centers) with a median duration of follow-up of 7.0 years. The

investigators examined cancer incidence, cancer deaths, and major

cardiovascular events (myocardial infarction, stroke, and

cardiovascular death), heart failure, unstable angina, and need for

cardiac revascularization. Among all HOPE patients, there were no

significant differences in the primary analysis: for cancer

incidence, 11.6% in the vitamin E group vs 12.3% in the placebo group

developed cancer (a non-significant reduction for vitamin E); for

cancer deaths, 3.3% in the vitamin E group vs 3.7% in placebo (also

not significant) and for major cardiovascular events, 21.5% vs 20.6%,

respectively (not significant). Of concern, was that patients in the

vitamin E group had a significantly higher risk of heart failure and

hospitalization for heart failure. The authors concluded that in

patients with vascular disease or diabetes mellitus, long-term

vitamin E supplementation does not prevent cancer or major

cardiovascular events and may increase the risk for heart failure.

Increased all-cause mortality:

A meta-analysis of randomized, 19 controlled clinical trials (135,967

participants) evaluating the dose-response relationship between

vitamin E supplementation and total mortality (Ann Intern Med. 2005

Jan 4;142(1):37-46. Epub 2004 Nov 10.) Published by and

associates at the s Hopkins School of Medicine, found High-dosage

(greater than or equal to 400 IU/d) vitamin E supplements may

increase all-cause mortality by 5% and should be avoided.

The Balanced Approach:

Perhaps a reasonable approach would be a three-tiered effort:

To moderately increase vitamin E levels with healthy dietary sources

of the vitamin (which may allow for an equivalent level of 15-45 IUs

per day from optimizing diet)

The addition of MODERATE levels of supplementation with NATURAL (d-

isomer) mixed tocopherols (which are closer to the mix seen in diet)

and

Use of minimum levels of vitamin E that have shown beneficial effect

(100 IU or greater) and not exceeding levels which have been

associated with risk (greater than 400 IU) and certainly not greater

than 1,600 IUs where increased risk seems to be more clearly defined

in some studies.

Source: Ohio State University Extension Fact Sheet

The 5-minute Neurology Consult By D. Joanne Lynn, Herbert B. Newton,

Rae-Grant published in 2003

Painful toxic myopathies hypervitaminosis e

http://books.google.com/books?id=Atuv8-rVXRoC & pg=PA300 & lpg=PA300 & dq=painful+toxi\

\

c+myopathies+hypervitaminosis+e & source=web & ots=Hqxv9MMBut & sig=-oRWZe7zRMQL2774uf\

\

7b1c6uUf0 & hl=en & sa=X & oi=book_result & resnum=1 & ct=result

Hypervitaminosis E is rare, but has been described in premature

infants and those on oral anticoagulants.

http://www.nmji.in/archives/volume%2016-4July%20August%202003/Correspondance/Vit\

\

amin%20E%20levels.htm

Posted 3/15/2005 8:48 PM Updated 3/16/2005 3:17 PM

High-dose vitamin E gets more bad news

By Liz Szabo, USA TODAY

A study in today's Journal of the American Medical Association is the

third in four months to question the health benefits of high-dose

vitamin E supplements.

In the study of nearly 4,000 patients, researchers found that

megadoses had no effect on the risk of cardiovascular disease or

cancer, but increased the risk of heart failure.

While some doctors say vitamin E still has potential in preventing

blindness and dementia, the study's authors say there is no reason

for patients to take high doses.

Multivitamins typically contain only 30 international units of

vitamin E, but many individual supplements include 400 units or more.

" There is this belief that you can take a miracle pill to prevent

diseases like heart disease and cancer, but it's just not true, " says

Eva Lonn, a leader of the study and a professor of medicine and

cardiology at McMaster University in Ontario, Canada. " Unfortunately,

we have to pay attention to our diet and exercise and our body

weight. "

Encouraging results from studies in the 1990s have helped make

vitamin E the most popular supplement, taken by 22% of adults over

55, according an editorial by E. Greenberg of Dartmouth

Medicine School published in January in ls of Internal Medicine.

Nutritional supplements had estimated sales of $19 billion in 2003.

In recent years, however, more rigorous clinical trials have failed

to show that vitamin E protects the heart.

Because this study is the first to suggest vitamin E may cause heart

failure - a condition in which the heart muscle doesn't pump blood as

it should - Lonn says doctors should conduct additional research to

make sure that this connection was not just a coincidence.

http://www.usatoday.com/news/health/2005-03-15-vitamin_x.htm

some of the studies have found that in certain cases, antioxidants,

including vitamin E, may actually increase the potential for

developing heart disease, cancer and a host of other health problems.

http://www.sciencedaily.com/releases/2006/03/060303110923.htm

Hypervitaminosis E

Weakness: Proximal

Myalgia

Serum CK: High

Muscle

Necrosis

GT stain: Paranuclear accumulation of red granular material

Inclusion staining pattern: NADH-TR, Acid phosphatase, Esterase

http://neuromuscular.wustl.edu/nother/vitamin.htm

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Thanks - that makes sense to me, unless I see some really concrete and

disturbing difference (which I understand some people may and do see which

is why these are all case by case, and I respect that) we will be staying

off - what I do tend to see is a slightly more unregulated behavior - -one

becomes weepy and extra sensitive, can get angry and upset more easily too,

(and this is stuff that is reported by the teacher too who doesn't know

about any of this - also, this is not small issue for him, up until last

year this would lead to up to 2 hour meltdowns regularly and it wasn't clear

whether he would be able to remain in his school, now they have completely

disappeared) but its not unmanageable, and the other becomes more

rambunctious in ways that sometimes are not helpful to him socially, he just

overdoes things, too loud, too much, etc. but again manageable and I think

they can both develop strategies to deal with that. Interestingly when they

are off fish oil (as the older one was for a few days because his school

went to camp on a 3 day trip) it subsides. So something about the fish oil

seems to deregulate them, but it helps their speech, organizational

abilities and focus so much that it outweighs the downsides. I also read

elsewhere that other people had this experience when they started the fish

oil but it subsided after a few weeks. When I first started my son on fish

oil (the older one) it actually didn't deregulate him, it just improved his

speech and focus. It was only after about a year on the fish oil that the

other behavior came up, and then I saw the vitamin e posts, and it seemed to

help him regulate back down a notch. Not perfectly mind you - but he's

always had some regulation issues anyway - pre fish oil - they just didn't

manifest the same way as they do now. So I hope that all makes sense - I

also think there are strategies they can use at this age (7 and 9) to help

regulate themselves as well. But if others have low or no risk

interventions viz this regulatory stuff, I'd love to know what they are!

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