Oral Yogurt 'Vaccine' Could Blunt Ouch Factor

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Oral Yogurt 'Vaccine' Could Blunt Ouch Factor

Study in mice reports a more powerful immune response than from an injection

Posted March 25, 2009

WEDNESDAY, March 25 (HealthDay News) -- Imagine how much nicer it would be to

get vaccinated by drinking a yogurt smoothie instead of being poked by a needle.

That might someday be the case, thanks to Northwestern University researchers

who developed a new oral vaccine using probiotics, which are healthy bacteria

found in dairy products such as yogurt and cheese.

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In a preclinical study, they found that this approach created immunity to

anthrax exposure. The researchers, from the Feinberg School of Medicine, are

also trying to develop probiotic-based vaccines for breast cancer and a range of

infectious diseases.

The method has more than the obvious no-pain advantage over needles. Delivering

the vaccine directly to the gut, they say, would utilize the full power of the

primary immune force, which is located in the small intestine.

" This is potentially a great advance in the way we give vaccines to people, " the

study's lead author, Mansour Mohamadzadeh, an associate professor of medicine in

gastroenterology, said in a university news release. " Then it's quickly

dispatched throughout your body. If you can activate the immune system in your

gut, you get a much more powerful immune response than by injecting it. The

pathogenic bacteria will be eliminated faster. "

In the study, the oral anthrax vaccine was fed to mice, which were then exposed

to anthrax bacteria. Eighty percent of the mice survived, about the same as mice

given an anthrax vaccine injection.

" Their immune response was higher and more robust than with the injected

vaccine, " Mohamadzadeh said.

The study was published in the Proceedings of the National Academy of Sciences.

More information

The U.S. National Institute of Allergy and Infectious Diseases has more about

vaccines.

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