5,000 IU/day of Vitamin D

[Guest guest]

The following information is extracted from Emerson Ecologics newsletter.

____________ _________ _________ _________ _________ _________ _

New Long-term Safety and Efficacy Data on the Long-Term use of 5,000 IU/day of

Vitamin D Emerge for a Nursing Home Population

Author: Steve Austin, N.D.

Reference: Mocanu V, Stitt PA, Costan AR, et al. Long-term effects of giving

nursing home residents bread fortified with 125 µcg (5000 IU) vitamin D3 per

daily serving. Am J Clin Nutr 2009;89:1132- 7.

Design: Unblinded intervention trial

Participants: Forty-five Romanian nursing home residents aged 58 to 89 years

Study Medication and Dosage: 5000 IU vitamin D3 per day provided in a fortified

bun, combined with 320 mg of calcium (Ca) from 800 mg of CaCO3

Primary Outcome Measures: Serum 25(OH)D levels and serum Ca levels were measured

at baseline and at three-month intervals until the completion of the trial at 12

months. Serum parathyroid hormone (PTH) levels were measured at baseline, at 6

months, at 9 months, and at 12 months. Z scores for bone mineral density (BMD)

of the lumbar spine and hip were measured at baseline and after 12 months.

Key Findings: Serum 25(OH)D levels increased 341% from baseline until the end of

the trial (beginning at a mean level of 28.5 nmol/L and ending at a mean level

of 125.6 nmol/L). By the trial end, more than nine out of ten subjects had

25(OH)D levels above 74 nmol/L-close to the 80 nmol/L now recommended by at

least some vitamin D researchers. PTH levels were significantly lower than

baseline at every subsequent measurement (P=0.001). Mean serum Ca remained

unchanged and no case of hypercalcemia developed during the trial. Lumbar BMD

measured in grams per cm2 increased by 4% (P<0.04). Hip BMD also increased by

23% (P<0.001). Both hip and lumbar z scores were also significantly improved by

the end of the trial (P<0.001).

Practice Implications: Vitamin D trials had once used doses averaging 400

IU/day. Mean levels then drifted upward to 800 IU, and then 1000 IU. More

recently, trials have begun to use 2000 IU daily doses.

The current trial suggests that at least for vitamin D-deprived elderly, 5000

IU/day of vitamin D provides evidence of improving vitamin D status (consistent

with the lowered PTH levels) but does not appear headed toward toxicity. (Note

that hypercalcemia did not occur, nor did serum Ca levels increase at all at 12

months.) The findings of this trial are also important because they reveal more

robust improvements in bone density than typically reported by older trials

using mostly lower doses of vitamin D.

Love, Gabby. :0)

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