What should I ask for in bloodwork?

[Guest guest]

My son had bloodwork done in Sept, but I'm still looking for more

accurate answers to what's going on inside him. Last time, his neuro

tested:

CBC (diff/ plts)

CMP 14

CPS/ Aldolase

T3/ T4 (free)/ TSH

Carnitine

Lead

Routine chromosones

Fragile X chromosomes

Urine Amino Acids

Urine Organic Acids

His iron was low (related to his diet, I'm sure), and I know his 1-

and 3-methylhistidine levels were off. The neuro is sending me to

retest his methylhistidines, since she said as a urine test, the

results could be due to human error.

What other tests can I have done while he's already getting his blood

drawn? So far, I know Vitamins A,D,E,K. Any other vitamins? Any

specific tests for gluten sensitivity? He's a carb freak, barely eats

fruits, veggies, or meats (Partially a sensory issue as well). What

else could I be missing?

The tests that were done above were done prior to starting fish oils.

I posted earlier that I took him off of his fish oils on Monday. How

long should I wait before his bloodwork? I'm going in Dec, but I

don't want him to have any oils in his body that could throw off the

tests.

Sorry if I'm repeating questions. Thanks for your help.

[Guest guest]

Take a look at message#53124

Also, low iron may not be related solely to diet but perhaps celiac,

diabetes, malabsorption. I would not let that one go. It was part of

our puzzle here and the knowledge we gained for my kids recently

helped my dad, a diabetic.

[Guest guest]

,  This is the

ASHA Position

Statement on CAS

Known

neurologic etiology: Stroke, trauma, infection1°

or 2 °

sign of complex neurobehavioral disorders (genetic, metabolic)Idiopathic

neurogenic speech sound disorder

These are some lab tests recommended for apraxia on this list by Dr,

whose own son is apraxic with a history of autoimmune disorders --asthma in his

case, metabolic disorders  and hypotonia. All of which have been greatly helped

by the fish oil + other diet/supplements to the point where he is almost fully

recovered, but without the supplements he regresses, or when there is an

inflammatory agent present--breach in diet, yeast /mold in environment etc.

These are his sensitivities. other kids may have other triggers.

Not all kids with apraxia have the exact same thing or the same metabolic issues

necessarily, but it is worth ruling them out or addressing them if present. It's

is all a guessing game at this point, there is research out there, but the

double blind clinical studies are not too practical for two main reasons:

1. not enough profit to do multi million dollar research--fish oil and diets and

supplements doesn't make Big Pharama rich;

2. All kids are slightly different it seems, require slightly different

protocols, some may need E some may not, some may need E + carnitine, other

something else--it all depends on the interactions between genetics and their

viral/bacterial/chemical/food exposure.  it's never that simple I'm afraid and

very often tests can rule out some causes but keep in mind that there are many

other genes or conditions or sensitivities, deficiencies etc that cannot yet be

tested for. My daughter has a family history of gluten intolerance--note-- not

the allergy, not Celiac necessarily and her blood work and skin tests showed

nothing--yet as I said her family history, behavior, autoimmune skin condition,

her malabsorptions and fatty acid deficiencies, along with B12 deficiencies and

carnitine deficiency etc. and of course her apraxia all point to a problem with

gluten as well and the casein sensitivity was present in her blood work.  Given

all these gluten

intolerance is assumed, and it can be visually observed on her skin as can corn

and soy intolerances which give her " chicken skin " and increase her rashes and

scalp psoriasis.  Just because there is no test sensitive enough to pick up

delayed reactions, we can safely assume gluten intolerance is present and we

already know gluten peptides in larger particles than normal in the blood

stream--for whatever reason affect the brain. So looking at all these symptoms

and knowing how often gluten is implicated in neurological disorders--pretty

much all non physical trauma type accidents--meaning neurological disorder of

unknown etiology have all been linked at some point to gluten intolerance-even

if it is not the primary cause necessarily, it feeds a vicious cycle of

oxidative stress that affects the brain in both the young and the old. 

In other words, very often gluten intolerance can be acquired as is my case and

the field of epigenetics confirms that environmental exposure activate genes

that are responsible for serious and often chronic disorders.

Common

Neurological “Soft Signs” that go with apraxia

•        

Limb dyspraxia – Coordination difficulties

Ø     

Gross and/or fine motor issues

•        

Low muscle tone (particularly truncal)

•        

Sensory Integration Dysfunction

Ø     

Poor Proprioception

Ø     

Poor Vestibular Sensation

Ø     

Abnormal pain processing/high pain tolerance

Ø     

Tactile defensiveness

Ø     

Overly sensitivity to light and/or noise

Common

Nutritional/Metabolic Deficiencies

•        

Carnitine deficiency

•        

Fat soluble vitamin deficiencies (ADEK)

•        

¯ Iron (True

deficiency vs. inflammation)

•        

Zinc deficiency

•        

¯ B-vitamins

•        

¯ Cholesterol

•        

¯ Albumen

•        

¯ omega 3 (DHA, EPA)

•        

Misc: ¯ amino acids, selenium, magnesium, calcium, glutathione

etc

Again, your child may not have any of this, but if you really want to rule

things out go biomed and these are some tests recommended for apraxia:

What Labs Should

Be Checked?

Plasma

Vit ADEK levels, zinc, copper, 

PIVKA-II (more sensitive test for Vit K deficiency ).Methylmalonic

acid (screen for B12 bioavailability).  SeleniumCarnitine

(total and free) and acyl-carnitine levelCeliac

panel (to include anti gliadin IgG, IgA, tTG and total IgA level)HLA

testing for DQ1, DQ2 and DQ8 allelesRAST

testing for common allergies (milk, casein)Serum

iron, ferriten, TIBCComprehensive

metabolic panel Cholesterol/lipid

profileComplete

blood count with diff (CBC)Lactic

acid, pyruvate CK

level, Plasma amino acids and urine organic acids if not already done

during previous metabolic work-up.

  Stool (Malabsorption screen):  Stool for fecal fat, pH and

reducing substances (qualitative fecal fat)

(Labs in blue are the priority

if you can’t get everything)

Hope this helps and I'm not sure I would keep the child off the fish oils for

months if it takes that long to get a DAN apt. and get the tests done.  Many

apraxic kids at age 2-3 recover almost fully on the oils and PROMPT to the point

where by school age they are indistinguishable.  That is provided there are no

other malabsorptions metabolic issues present. If there are they need to be

addressed before the oils and the PROMPT can actually work at their best.  Now,

are these recovered children still apraxic?---those with older recovered

children claim yes, regressions can occur when supplements are stopped,

inflammatory triggers are present--be they food intolerance, viral, bacterial,

chemical, parasitic in nature.

And again, not all kids need this or have this phenotype etc., but since you're

looking for answers and want to leave no stone unturned....

Good luck!

Elena

From: <cp_mistyrose@...>

Subject: [ ] What should I ask for in bloodwork?

Date: Saturday, November 29, 2008, 5:17 PM

My son had bloodwork done in Sept, but I'm still looking for more

accurate answers to what's going on inside him. Last time, his neuro

tested:

CBC (diff/ plts)

CMP 14

CPS/ Aldolase

T3/ T4 (free)/ TSH

Carnitine

Lead

Routine chromosones

Fragile X chromosomes

Urine Amino Acids

Urine Organic Acids

His iron was low (related to his diet, I'm sure), and I know his 1-

and 3-methylhistidine levels were off. The neuro is sending me to

retest his methylhistidines, since she said as a urine test, the

results could be due to human error.

What other tests can I have done while he's already getting his blood

drawn? So far, I know Vitamins A,D,E,K. Any other vitamins? Any

specific tests for gluten sensitivity? He's a carb freak, barely eats

fruits, veggies, or meats (Partially a sensory issue as well). What

else could I be missing?

The tests that were done above were done prior to starting fish oils.

I posted earlier that I took him off of his fish oils on Monday. How

long should I wait before his bloodwork? I'm going in Dec, but I

don't want him to have any oils in his body that could throw off the

tests.

Sorry if I'm repeating questions. Thanks for your help.

------------------------------------

[Guest guest]

Ask to have creatine tested. My son tested low on this and we

started supplementing with creatine ethyl ester. We've gotten a

tremendous increase in expressive language.

Creatine is normally associated with hypotonia, etc... My son is big

and strong but it helps with his speech.

>

> My son had bloodwork done in Sept, but I'm still looking for more

> accurate answers to what's going on inside him. Last time, his

neuro

> tested:

>

> CBC (diff/ plts)

> CMP 14

> CPS/ Aldolase

> T3/ T4 (free)/ TSH

> Carnitine

> Lead

> Routine chromosones

> Fragile X chromosomes

> Urine Amino Acids

> Urine Organic Acids

>

> His iron was low (related to his diet, I'm sure), and I know his 1-

> and 3-methylhistidine levels were off. The neuro is sending me to

> retest his methylhistidines, since she said as a urine test, the

> results could be due to human error.

>

> What other tests can I have done while he's already getting his

blood

> drawn? So far, I know Vitamins A,D,E,K. Any other vitamins? Any

> specific tests for gluten sensitivity? He's a carb freak, barely

eats

> fruits, veggies, or meats (Partially a sensory issue as well). What

> else could I be missing?

>

> The tests that were done above were done prior to starting fish

oils.

> I posted earlier that I took him off of his fish oils on Monday.

How

> long should I wait before his bloodwork? I'm going in Dec, but I

> don't want him to have any oils in his body that could throw off

the

> tests.

>

> Sorry if I'm repeating questions. Thanks for your help.

>