Natural killer cell activity in a longitudinal dietary fat intervention trial.

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Hi All,

It would seem that lowering ones fat intake, improves the activity of NK cell

activity and thus improving the killing of

early stage cancer cells. About 0.8 % increase in NK activity for each % of

dietary fat decreased was observed.

I try to keep my total fat intake at around 20 % (40 g on 1,800 cals) based on

the DWIDP diet analysis software.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=2\

293903 & dopt=Abstract

Clin Immunol Immunopathol 1990 Jan;54(1):103-16 Related Articles, Books, LinkOut

Natural killer cell activity in a longitudinal dietary fat intervention trial.

Hebert JR, Barone J, Reddy MM, Backlund JY.

Division of Preventive and Behavioral Medicine, University of Massachusetts

Medical School, Worcester 01655.

It has been hypothesized that dietary fat may affect natural killer (NK) cell

activity, a factor of potential importance

in early tumor surveillance.

Fourteen men successfully completed an intervention trial designed to test the

effect of dietary fat on NK activity in

humans.

Study subjects lowered their fat intake to an average of 22% of calories as fat

and consumed two dietary supplements (of

coconut and safflower oils), in a cross-over design.

These supplements resulted in large changes in the ratio of polyunsaturated to

saturated fatty acids (1.73 to 0.34, on

average).

Results of a general linear model in which we fitted covariates on exercise,

body mass, intervention sequence, and

various dietary predictors revealed a significant effect of decreased total

dietary fat intake on increased NK activity

at an E/T ratio of 100:1 (about 0.79% increase for each absolute percent of

calories as fat, P = 0.04). Similar results

were obtained at E/T ratios of 50:1 and 25:1.

No other nutritional predictor was significantly associated with NK activity at

any E/T ratio.

PMID: 2293903 [PubMed - indexed for MEDLINE]

========================

Here is another:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=2\

801592 & dopt=Abstract

Am J Clin Nutr 1989 Oct;50(4):861-7 Related Articles, Books, LinkOut

Dietary fat and natural-killer-cell activity.

Barone J, Hebert JR, Reddy MM.

Division of Epidemiology, American Health Foundation, New York, New York.

An intervention trial designed to lower the amount of fat in the diet was

conducted to test the effect of reduced fat

consumption (LF diet) on activity of natural killer (NK) cells in humans.

Of 26 men enrolled initially, 17 successfully completed the intervention and

lowered their fat intake to less than 30%

of calories as fat.

Data were analyzed in two ways. The paired t test showed a marked increase in

NK-cell activity from baseline to the end

of the LF-diet intervention (t = 4.77, p = 0.0002).

Results of a general linear model showed an effect of lowering total dietary fat

on increased NK-cell activity

(approximately 0.53% increase for each absolute percent of calories as fat, p =

0.14) for all men and a highly

significant effect in a subset of men who ate greater than 25% of calories as

fat at baseline (approximately 1.22%

increase, p = 0.009).

These results were obtained after changes in total caloric intake, weight,

exercise, and other fat-related covariates

were accounted for.

PMID: 2801592 [PubMed - indexed for MEDLINE]

========================

Optimal Health & Longevity,

Greg ,

http://optimalhealth.cia.com.au

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