Castration Drug Used as Autism Therapy

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Castration Drug Used as Autism Therapy

Controversial treatment now in some medical offices.

Bob LaMendola

South Florida Sun-Sentinel

August 3, 2010

A land medical group has started treating autistic children in South

Florida with shots of a drug used for chemical castration, a therapy widely

panned by mainstream experts.

The group gives children the cancer drug Lupron to stop their bodies from making

testosterone, saying the drug helps expel toxic mercury and quells aggressive or

sexually explicit behavior by kids with excessive levels of the male hormone.

A Boca Raton mother who just put her 18-year-old son on the drug said it seems

to help.

But numerous physicians, researchers and therapists insist there's no proof

mercury causes autism, that Lupron removes mercury or that autistic kids have

excessive testosterone. What's more, the drug carries a risk of bone damage,

stunted growth and heart trouble, and can render children impotent.

These experts contend that Lupron, costing about $5,000 a month but seldom

covered by insurance, is one of many treatments that cash in on the desperation

of parents trying to cope with an incurable condition for which medicine has few

good answers outside of painstaking behavioral therapy.

" Not only is there no scientific backing whatsoever for Lupron treatments, there

are several major concerns for the children's health, " said neurologist BethAnn

McLaughlin, an adviser to the Dan Marino Foundation autism group in Weston and

the mother of two developmentally disabled children.

" These people are preying on the fears of parents. We cannot be using these

children who are so vulnerable as guinea pigs in a medical experiment. "

Untested autism treatments have flourished while science struggles to explain

the disorder, which disrupts the abilities to speak, concentrate, connect with

people and control impulses.

For unknown reasons, autism has been on the rise for the past few decades, with

an estimated 675,000 children – about one in 100 – now having mild to severe

symptoms. Scientists believe it stems from genetic defects that may only cause

problems after an environmental trigger.

A vocal subset of parents and activists blame vaccines, especially those with

the mercury-based preservative thimerosal, which has been banned from virtually

all as a precaution. Numerous studies have found no connection between autism

and vaccines or thimerosal.

Lupron therapy grew from the mercury camp. Baltimore researcher Dr. Mark Geier

started using the drug in 2005 on the theory – disputed by mainsteam doctors –

that testosterone binds mercury in the body and that many autistic kids have

high levels of the hormone.

Lupron halts production of the female hormone estrogen, which the body uses to

make testosterone. The drug mainly is used to treat endometrial cancer in women

and prostate cancer in men, and sometimes to chemically castrate sex offenders.

Geier's promotional materials said he has treated hundreds of children with

Lupron and has launched nine ASD Centers in eight states. In his latest, he

teams with Dr. Clayman, a Boca Raton radiologist who has an autistic teen

son and is opening an ASD office beside his MRI center in Tamarac.

Clayman said he would not comment until he treats patients with Lupron therapy

for a year. Geier could not be reached for comment despite several attempts by

phone. He told one parent he did not plan to comment for this story.

The medical group began recruiting Florida patients in March when Geier spoke at

a Fort Lauderdale conference for parents of children with autism.

Badillo was at the meeting. Her family has searched in vain for a way to

help their autistic son, Marco, 18. Badillo said he has little speech or

interaction with others, but is doing OK in high school. Lately, though, Marco

has grown more aggressive, physical and rebellious.

" We were basically under seige in this house, " Badillo said. " This kind of

behavior is more scary at 18 [than] at 3. I had choices to make. If you see

there is another option out there that can help your child, most parents are

going to choose that option. "

Also, Marco had discovered sex and sometimes touched himself inappropriately in

public, a common problem among those with autism.

" The kids don't understand. They have impulses. It's what happens when you have

high testosterone, " Badillo said.

The family put Marco on Lupron about six weeks ago. He gets two injections a

month at a dosage larger than used on adult cancer patients, plus a small daily

shot.

" The therapy immediately stopped the aggression, " Badillo said. " This is not

castrating a kid. It's just lowering the [testosterone] levels enough to normal

range so the kid is not aggressive. "

She said Geier plans to continue the Lupron for several months to see if it

helps Marco's other autistic behavior. She said she knows the drug has risks but

believes Lupron critics do not fully grasp the hard realities of life with an

autistic child.

Lupron critics said autism parents may not understand the dangers.

The drug is not approved for children – except a rare few with premature puberty

– because it can impair bone development crucial to growth, said Dr.

Berkovitz, chief of pediatric endocrinology at the University of Miami medical

school.

It's not recommended for people with heart disease, kidney disease, asthma,

depression or seizures because it can worsen those conditions. Autistic children

are prone to seizures.

" It has not been tested so there's no way to know if it has adverse effects in

the long run, " Berkovitz said.

Said neurologist McLaughlin: " We have very significant concerns about

irreversible damage to sexual function and the brain and sex organs of these

children. "

In addition, the Food and Drug Administration is investigating complaints that

Lupron causes diabetes in adults.

Geier published a 2006 study contending that 11 autistic children taking Lupron

did better on tests of awareness, sociability and behavior. He has since issued

other studies finding that mercury leads to excess testosterone and that

autistic children have excessive levels of the hormone.

Other doctors said Geier's studies were small, were not scientifically sound and

were published in journals that do not follow the standard practice of having

experts review the methods.

The area's largest autism treatment center jointly run by the University of

Miami and Nova Southeastern University, as well as another at Florida Atlantic

University, frown on Lupron and other untested therapies, officials at the

centers said.

Dr. Judith Aronson-Ramos, a developmental pediatrician in Coconut Creek, said

practitioners promoting untested alternative treatments often appeal to parents

by portraying themselves as persecuted rebels.

" It's always just 'The medical establishment is against us,' " Aronson-Ramos

said.

Two doctors said Lupron may be gaining traction, because several families have

asked them to test their children's testosterone levels.

" Parents get desperate, " said Debbie Chanan, an autism program coordinator at

Florida Atlantic University. " Parents will spend all their money. "

" Your first instinct as a parent is to try to fix things for your child, " said

Carol Nigro, mother of an autistic son and a coordinator at the Dan Marino

Center in Weston. " Autism doesn't have a fix. "

McLaughlin said parents should stick with slow and difficult but proven

therapies. Teens struggling with sex can benefit from counseling, rewards for

positive behavior, jobs or activities to keep them focused and, if needed, drugs

to treat anxiety or sleep issues, she said.

" What we know works is a rough course, " she said. " Yes, we can do better. But

what we don't want is for families to lose faith in science and go off with

people who … are violating the first rule of being a doctor, which is 'first do

no harm.' "

, South Florida Sun-Sentinel