Olive Oil Dampens Genes Responsible for Inflammation

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Spanish researchers identify 98  genes whose inflammatory activity is dampened

by consumption of olive oil, suggesting the underlying mechanism by which it

exerts beneficial effects on chronic conditions from arthritis to heart disease.

Francisco -Jimenez, from University of Cordoba (Spain),and colleagues

studied 20 patients with metabolic syndrome, who ate breakfast foods covered in

two types of olive oil, either extra virgin olive oil (high in phenol

compounds), or a low-phenol oil.   Those subjects who ate the breakfast

containing olive oil rich in phenolic compounds were found to have a reduced

expression of pro-inflammatory genes associated with cardiovascular disease and

diabetes, as compared to those who ate the low-phenolic olive oil breakfast. 

Concluding that: “This study shows that intake of a breakfast based in virgin

olive oil rich in phenol compounds is able to repress the in vivo expression of

several pro-inflammatory genes,

thereby switching the activity of peripheral blood mononuclear cells to a less

deleterious inflammatory profile,†the researchers submit that: “These

results provide at least a partial molecular basis for the reduced risk of

cardiovascular disease observed in Mediterranean countries, where virgin olive

oil represents the main source of dietary fat.â€

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