EEG and MRI findings and their relation with intellectual disability in pervasive developmental disorders.

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http://www.ncbi.nlm.nih.gov/pubmed/19693463?ordinalpos=4 & itool=EntrezSystem2.PEn\

trez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

 

EEG and MRI findings and their relation with intellectual disability in

pervasive developmental disorders.

 

Unal O, Ozcan O, Oner O, Akcakin M, Aysev A, Deda G.

 

Department of Developmental and Behavioral Pediatrics, Ankara University School

of Medicine, Ankara, Turkey, unalozlem@....

BACKGROUND: The diagnostic category pervasive developmental disorders (PDDs)

refer to a group of five disorders: autism, Rett syndrome, childhood

disintegrative disorder, Asperger syndrome, and pervasive developmental disorder

not otherwise specified (PDD-NOS). EEG abnormalities and seizures are considered

much frequent in autistic subjects with comorbid intellectual disability (ID).

In this study, we aimed to evaluate the EEG and MRI findings and their relation

with ID in pervasive developmental disorder. METHODS: A retrospective,

cross-sectional and non-experimental study was performed. Subjects included 81

patients diagnosed with autism or PDD-NOS according to the DSM-IV criteria. The

age range of the patients was 2-15 years (mean 6.6 years, SD 3.0). Among them,

21 (25.9%) were girls and 60 boys (74.1%). RESULTS: Patients with severe ID had

a higher rate of EEG abnormalities (P=0.03) than patients without ID as well as

patients with mild or moderate

ID. The association remained significant after the structural MRI abnormalities

were controlled (P=0.04). The severity of ID was not associated with abnormal

MRI. The most frequent EEG and MRI abnormalities were active epileptic

anomaly/paroxysmal abnormality and cerebral atrophy/periventricular

leukomalacia, respectively. Almost a third of the EEG abnormalities were

associated with temporal cortex and adjacent cortical structures.

 

CONCLUSIONS: Consistent with previous studies, almost a fourth of the patients

in this relatively large sample of patients with pervasive developmental

disorders had EEG and/or MRI abnormalities. EEG results indicate that temporal

cortex may play a significant role in pervasive developmental disorders.

PMID: 19693463 [PubMed - in process]

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" I know of nobody who is purely Autistic or purely neurotypical. Even God had

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