Low fatty acid unsaturation: a mechanism for lowered lipoperoxidative modification of tissue proteins in mammalian species with long life spans.

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Hi All,

Interesting paper relating life span in many species to their level of dietary

unsaturated fatty acids. Seems the lower

the level of unsaturated fatty acids the better for increased life span. Note

the last line:

" We propose that a low degree of fatty acid unsaturation may have been selected

in longevous mammals to protect their

tissue lipids and proteins against oxidative damage while maintaining an

appropriate environment for membrane function. "

Still think highly unsaturated double bond rich fatty acid oils & fats are good

for you?

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

0843345 & dopt=Abstract

J Gerontol A Biol Sci Med Sci 2000 Jun;55(6):B286-91 Related Articles, Books,

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Low fatty acid unsaturation: a mechanism for lowered lipoperoxidative

modification of tissue proteins in mammalian

species with long life spans.

Pamplona R, Portero-Otin M, Riba D, Requena JR, Thorpe SR, - M, Barja

G.

Department of Basic Medical Science, University of Lleida, Spain.

Carbonyl compounds generated by the nonenzymatic oxidation of polyunsaturated

fatty acids react with nucleophilic groups

in proteins, leading to their modification.

It has not been tested whether fatty acid unsaturation is related to

steady-state levels of lipoxidation-derived protein

modification in vivo.

A low fatty acid unsaturation, hence a low protein lipoxidation, in tissues of

longevous animals would be consistent

with the free radical theory of aging, because membrane lipids increase their

sensitivity to oxidative damage as a

function of their degree of unsaturation.

To evaluate the relationship between fatty acid composition, protein

lipoxidation, and maximum life span (MLSP), we

analyzed liver fatty acids and proteins from seven mammalian species, ranging in

MLSP from 3.5 to 46 years.

The results show that the peroxidizability index of fatty acids and the

sensitivity to in vitro lipid peroxidation are

negatively correlated with the MLSP.

Based on gas chromatography and mass spectroscopy analyses, liver proteins of

all these species contain

malondialdehyde-lysine and Nepsilon-carboxymethyllysine adducts, two biomarkers

of protein lipoxidation.

The steady-state levels of malondialdehyde-lysine and Nepsilon-carboxymethyl

lysine are directly related to the

peroxidizability index and inversely related to the MLSP.

We propose that a low degree of fatty acid unsaturation may have been selected

in longevous mammals to protect their

tissue lipids and proteins against oxidative damage while maintaining an

appropriate environment for membrane function.

PMID: 10843345 [PubMed - indexed for MEDLINE]

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Good Health & Long Life,

Greg , http://optimalhealth.cia.com.au gowatson@...

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