folic acid

[Guest guest]

My daughter also takes 1 mg of the folic acid...

Lori

On Thu, Feb 19, 2009 at 12:56 PM, son <newmom2003@...>wrote:

>

> Hadley,

>

> Audrey is on .6 cc of mtx weekly. When her eyes flared, they upped her mtx

> dose, but not the folic acid. Boy, did we see the effects - the nausea and

> vomiting were horrible. She's now gone from 1 mg to 2 mg of folic acid and

> she does okay. But interestingly, if we even miss one dose of the folic

> acid, she's up the next morning with the vomiting, even if she hasn't had

> her mtx the night before. Audrey is 5, and her's is prescribed by her

> doctor, and insurance covers it. We just crush it in a pills crusher, and

> mix it with some naproxen. It seems to help her sleep better at night, and

> we give them both to her with dinner.

>

> D.

>

> Salt Lake City

>

>

>

> < %40>

> From: hmessner@... <hmessner%40verizon.net>

> Date: Thu, 19 Feb 2009 17:22:16 +0000

> Subject: Folic Acid

>

> Where are you all getting your children's folic acid? Is it

> prescribed? We have always given multi-children's vitamins with folic

> acid but I hear a lot of you mentioning taking more than this. Is

> there a chewable or are your kids older and able to swallow an extra

> folic acid vitamin? Curious...

>

> -Hadley (Isabelle, 5 yrs.)

>

> __________________________________________________________

> Get more out of the Web. Learn 10 hidden secrets of Windows Live.

> http://windowslive.com/connect/post/jamiethomson.spaces.live.com-Blog-cns

> !550F681DAD532637!5295.entry?ocid=TXT_TAGLM_WL_domore_092008

>

>

[Guest guest]

Hadley,

My 4 year old has been taking Folic Acid since diagnoses almost 2 years

ago. She was prescribed this by her ped rheumy in addition to the

folic acid in her multivitamin. She started out swallowing the three

pills just fine but last spring started gagging and wretching every

time. Our pharmacy was able to compound them with a syrup that she

took and liked okay. Just last month we began using a mail-in pharmacy

and they were unable to make the syrup and the pills they sent were a

little bigger. We began crushing them and mixing them with her

Meloxicam but every time she felt a tiny bit that hadn't been

completely pulverized she would gag again. Just this week I tasted a

little piece of the pill (curiousity got the better of me) and realized

it tasted sweet. Now she is just chewing them up and we are both

thrilled! Go figure!

Hope this helps,

Kirsten mom to , age 4, spondylo

>

> Where are you all getting your children's folic acid? Is it

> prescribed? We have always given multi-children's vitamins with

folic

> acid but I hear a lot of you mentioning taking more than this. Is

> there a chewable or are your kids older and able to swallow an extra

> folic acid vitamin? Curious...

>

> -Hadley (Isabelle, 5 yrs.)

>

[Guest guest]

Hadley,

My 4 year old has been taking Folic Acid since diagnoses almost 2 years

ago. She was prescribed this by her ped rheumy in addition to the

folic acid in her multivitamin. She started out swallowing the three

pills just fine but last spring started gagging and wretching every

time. Our pharmacy was able to compound them with a syrup that she

took and liked okay. Just last month we began using a mail-in pharmacy

and they were unable to make the syrup and the pills they sent were a

little bigger. We began crushing them and mixing them with her

Meloxicam but every time she felt a tiny bit that hadn't been

completely pulverized she would gag again. Just this week I tasted a

little piece of the pill (curiousity got the better of me) and realized

it tasted sweet. Now she is just chewing them up and we are both

thrilled! Go figure!

Hope this helps,

Kirsten mom to , age 4, spondylo

[Guest guest]

Hello All,

I wanted to pass along some information that has helped my daughter. My daughter

has verbal and motor dyspraxia, spd and some low muscle tone. At the age of four

she was using only a handful of words regularly, and had said maybe 30 words

total.

For two years we have been giving her high quality fish oils, speech therapy,

OT, lots of play therapy, a gf/cf diet, and listening therapy. None of these

seemed to help her with her speech, though listening therapy and OT were

beneficial in other ways.

Five months ago her naturopath tested her for a genetic glitch called MTHFR that

interferes with the body processing folate. We put her on MTHF (methelated

folate)and words started coming within a week. Her progress has continued since

then and she is now putting three words together. The gene mutation is not that

uncommon, and there are health concerns that are related to it later in life,

but treatment is easy: taking folic acid... methelated folate is better.

I also should add that most doctors would see that she only has one faulty

marking (from one parent) and they would conclude that she's fine. But our

naturopath specializes in quirky kids and knows that this supplement can really

help.

Best wishes to you all,

[Guest guest]

Interesting...folic acid is found naturally in NV from the whole food- not sure

which food or foods in NV -but 400 mcg per 2 scoops. You can see that here

http://pursuitofresearch.org/ingredients.html (just click on the image of the

label for either chocolate or vanilla...none of the vitamins or minerals are

added -they are all from the whole food -which you see as the list of

ingredients)In addition to having all these nutrients and ALL the essential

amino acids per serving -NV is 100 percent water soluble. Whole food

supplementation is the purest way to get a nutrient -and unless allergic to a

food without the risks of just supplementing. For example these are the side

effects of supplementing with folic acid

http://www.drugs.com/sfx/folic-acid-side-effects.html -and keep in mind with

children you first want UTL is for their age and weight -for folic acid I also

read that you don't want to supplement for extended periods of time or that can

lead to problems- again that is all from when you just take the individual supp

and not when you just consume it in food. What dosage did he put your child on?

Another possible reason NV is working? Life made simple by NV -and we just keep

learning more of the great things in simple things!!

=====

[Guest guest]

my daugther also tested ++ for the MTHFR gene as well.....dr bock (DAN

DR---although she has apraxia (oral), low tone adn some dev delays) put her on

methylfolate BUT we think she had a reaction to it....she spiked a fever of 103

BOTH times we gave it to her so we took her off....he wants to put her on some

other type of folate now but i haven't added it yet....a little leary being she

reacted to the methylfolate....

[Guest guest]

MTHFR  is Methylenetetrahydrofolate reductase.  MTHFR is actually the name of

the gene and there can be many mutations on this gene.  If there is a mutation

of this gene there is a risk for venous thrombosis so a Factor 5 Leiden test is

also usually ordered.  They are blood tests and only 1 tube is of blood is

needed.  A mutation of this gene can also cause  hyperhomocysteinemia which

can be caused by a folate deficiency.

I

From: Tatyana Haddock <thaddock@...>

Subject: Re: [ ] folic acid

Date: Saturday, October 16, 2010, 6:53 PM

Can you elaborate on how testing is done for this mutation? Also, what is

the full name of the condition (i.e. what does MTHFR stand for?)? What kind of

methalated folate dosage (range, not exact) is needed for this condition - I'm

asking b/c I do give my son supplements that have folate in it, but what is a

therapeutic dose for the condition?

Thanks for the info on this!

Tatyana

[Guest guest]

Interesting. My son, (3yrs old) also tested positive for MTHFR c677T

homozygous. The DAN doc that did the testing also suggested a Rx level

Folate/Folapro (something like that), but we weren't fond of the doc so we

didn't proceed with many of her suggestions. We visited a more traditional doc

at Childrens Hospital and he said unless 's homocystein levels were elevated

we shouldn't worry. We haven't checked the levels yet and I'm sure different

mutations of MTHFR require different things, perhaps.

However, I am very interested in hearing more about this - what your child is

taking, how much, etc. I haven't given any additional folic acid as of yet

(aside from what he gets in 1 scoop of NV), but given MTHFR situation might make

it even harder for their bodies to process/use folic acid, I might talk with our

doc again about this.

I recently found out I Have the mutation as well and am pregnant. My doc, as

well as 2 different perinatal specialists all pu me on MASSIVE levels of folic

acid (4 mg/day) - whereas the normal prenatal pill has 800 mcgs (1/5th what I'm

taking)

Very very interesting. Thanks for sharing.

Sharon

>

> my daugther also tested ++ for the MTHFR gene as well.....dr bock (DAN

DR---although she has apraxia (oral), low tone adn some dev delays) put her on

methylfolate BUT we think she had a reaction to it....she spiked a fever of 103

BOTH times we gave it to her so we took her off....he wants to put her on some

other type of folate now but i haven't added it yet....a little leary being she

reacted to the methylfolate....

>

>

>

>

>

[Guest guest]

Something else to know about this gene " defect " that half of us have by the way

" There is a MTHFR mutation that is present in up to 50% of the population "

W. Erbe, M.D., FACMG Professor of Pediatrics and Medicine, University at

Buffalo Chief, Division of Genetics, Women & Children's Hospital ... so..... I'd

get second opinion from a traditional medical doctor as if half of us have some

form of this mutation...one would think you should know this too prior to

" treatment " and if one did want to do treatment again I'd go with food -or check

with an expert in this area such as a Dr. Erbe. This comes up most often for

pregnancy as women don't even know they have this " mutation " (I don't know

-again do you call something a mutation when about half of us have it?!!!) until

they keep having miscarriages.

The way to find out if you have this since it appears you can have it and not

know is with a blood test. So if one gets their child tested for this and they

test positive perhaps the mother go for the blood test too and then the whole

family should start eating more folic acid in the diet.

And...if someone with this has trouble with efficiently metabolizing folic acid

I would (again) say it's better to consume more folic acid in the diet. And

outside of NV which again has 200 mcg of folic acid from whole food per scoop

http://pursuitofresearch.org/ingredients.html you could increase consumption of

eggs, dark leafy vegetables, (spinach and broccoli) oranges and orange juice and

legumes (peas and dried beans)

The only huge thing to be aware of ...and I'm guessing based on the odds of

having this if you are part of the human race -and as they point out -this is

very rare (obviously as I don't know if this happened more than one time?

Warning -very sad tragic story -but again very rare)

Nitrous Oxide Anesthesia Implicated in Death of Child With MTHFR

Deficiency

By J. Brown, MD

NEW YORK (Reuters Health) Jul 02 - Nitrous oxide anesthesia

administered to a child born with an undiagnosed deficiency in a

key metabolic enzyme appears to have caused the child's death,

according to a report published in the July 3rd issue of The New

England Journal of Medicine.

The deficient enzyme, 5,10-methlyenetetrahydrofolate reductase

(MTHFR), is involved in the metabolism of folate and in the

production of methionine, which is needed for a variety of

important biochemical reactions, senior author Dr. Kirk Hogan,

from the University of Wisconsin in Madison, and colleagues

note.

In the current case, because of the enzyme deficiency, the child

probably had baseline methionine levels that, although low, were

survivable. Unfortunately, in this situation treatment with

nitrous oxide, an agent known to block methionine synthesis,

may have resulted in fatally low levels.

The case involved a male infant who appeared normal until 3 months of

age when he presented with a mass in the left leg. Excisional biopsy of the

lesion was performed under anesthesia that included nitrous oxide. The procedure

lasted 45 minutes and the pathology results indicated fibrosarcoma.

The child was taken back to the OR four days later for complete

resection of the mass. Once again, nitrous oxide-containing anesthesia

was administered, but this time the procedure lasted 270 minutes. Still, the

patient was discharged on postoperative day 7 in seemingly good health.

Seventeen days after discharge, the infant was admitted to the

hospital with seizures and apnea episodes. The patient was found to

be severely hypotonic and CT scan revealed generalized brain atrophy

with enlarged prepontine and medullary cisterns. In addition, plasma

methionine levels were low, while homocysteine levels were elevated-

-both findings consistent with a MTHFR deficiency.

Forty-six days after surgery, the infant died after respiratory arrest.

Postmortem examination showed extensive damage to the

central nervous system.

Although it was not known at the time of surgery, two of the child's

relatives had elevated homocysteine levels. However, none had ever

been treated with nitrous oxide.

The case was initially reported in 1987, but at that time the

technology was not available to test for MTHFR activity or for

mutations in the corresponding gene, Dr. W. Erbe, co-author

of a related editorial, told Reuters Health.

When Dr. Hogan's team went back and tested fibroblast samples from the

patient and his family, they found a novel MTHFR mutation associated

with severely decreased enzyme activity.

" I don't think these results should cause panic among the general

public, " Dr. Erbe, from the University at Buffalo, noted. " There were

clues in this particular case that suggested a problem before the

nitrous oxide was given, " he added.

Moreover, the MTHFR mutation in the current case appears to be

rather rare, Dr. Erbe said. " There is a MTHFR mutation that is present in up to

50% of the population, but there is no evidence that nitrous oxide is unsafe for

carriers of this mutation. "

However, in children with developmental delay or altered homocysteine

metabolism, methionine levels should be determined before using

nitrous oxide-containing anesthesia, he noted.

Carcinogenesis. 2003 Jun;24(6):1097-103. Epub 2003 Apr 24.

Folate status, metabolic genotype, and biomarkers of genotoxicity in

healthy subjects. http://www.nejm.org/doi/full/10.1056/NEJMoa021867

And...if someone with this has trouble with efficiently metabolizing folic acid

I would (again) say it's again better to try to support the metabolic system by

whole foods- and try to consume more folic acid in the diet. And outside of NV

which again has 200 mcg of folic acid from whole food per scoop

http://pursuitofresearch.org/ingredients.html you could increase consumption of

eggs, dark leafy vegetables, (spinach and broccoli) oranges and orange juice and

legumes (peas and dried beans)

=====

[Guest guest]

Hello,

My son also has the MTHFR C677t single mutation. He has high homocysteine

levels. this is an issue with the methel cycle which requires B12, B6 and

folate. Folic acid is not the best supplement. Folopro, folate, folonic acid is

all better for this. BUT they need all 3 listed above for the methel cycle to

work. My son now has Nitrous oxcide listed as allergies. He had it once and it

made him off the wall, hyper. This MTHFR can be a sneaky condition that masks

itself as many things. My child presented as ADHD but from working with a Dr who

studied and published the effects of vitamin B on these kids my child is no

longer considered ADHD, doesn't qualify. The amino acids lisa speaks of can be

beneficial. I use the nutriveda in his pudding but am no where the recommended

dosage. Finding out about this condition about 6 mnths ago, I have read and

read, consulted and tried so many things. We have found our happy doses of the

supplements he needs and he is fabulous. I cannot say his speech is all that

better, all in all he is doing great. Also I am taking the supplements and I

feel so much better, no more feeling tired all day!! The nutriveda can be a

wonderful addition to the other vitamins your child may need, but you need those

b vitamins with folinic acid to get his methel cycle working!

>

> Something else to know about this gene " defect " that half of us have by the

way " There is a MTHFR mutation that is present in up to 50% of the population "

W. Erbe, M.D., FACMG Professor of Pediatrics and Medicine, University at

Buffalo Chief, Division of Genetics, Women & Children's Hospital ... so..... I'd

get second opinion from a traditional medical doctor as if half of us have some

form of this mutation...one would think you should know this too prior to

" treatment " and if one did want to do treatment again I'd go with food -or check

with an expert in this area such as a Dr. Erbe. This comes up most often for

pregnancy as women don't even know they have this " mutation " (I don't know

-again do you call something a mutation when about half of us have it?!!!) until

they keep having miscarriages.

>

> The way to find out if you have this since it appears you can have it and not

know is with a blood test. So if one gets their child tested for this and they

test positive perhaps the mother go for the blood test too and then the whole

family should start eating more folic acid in the diet.

>

> And...if someone with this has trouble with efficiently metabolizing folic

acid I would (again) say it's better to consume more folic acid in the diet.

And outside of NV which again has 200 mcg of folic acid from whole food per

scoop http://pursuitofresearch.org/ingredients.html you could increase

consumption of eggs, dark leafy vegetables, (spinach and broccoli) oranges and

orange juice and legumes (peas and dried beans)

>

> The only huge thing to be aware of ...and I'm guessing based on the odds of

having this if you are part of the human race -and as they point out -this is

very rare (obviously as I don't know if this happened more than one time?

Warning -very sad tragic story -but again very rare)

>

>

>

> Nitrous Oxide Anesthesia Implicated in Death of Child With MTHFR

> Deficiency

> By J. Brown, MD

>

> NEW YORK (Reuters Health) Jul 02 - Nitrous oxide anesthesia

> administered to a child born with an undiagnosed deficiency in a

> key metabolic enzyme appears to have caused the child's death,

> according to a report published in the July 3rd issue of The New

> England Journal of Medicine.

>

> The deficient enzyme, 5,10-methlyenetetrahydrofolate reductase

> (MTHFR), is involved in the metabolism of folate and in the

> production of methionine, which is needed for a variety of

> important biochemical reactions, senior author Dr. Kirk Hogan,

> from the University of Wisconsin in Madison, and colleagues

> note.

>

> In the current case, because of the enzyme deficiency, the child

> probably had baseline methionine levels that, although low, were

> survivable. Unfortunately, in this situation treatment with

> nitrous oxide, an agent known to block methionine synthesis,

> may have resulted in fatally low levels.

>

> The case involved a male infant who appeared normal until 3 months of

> age when he presented with a mass in the left leg. Excisional biopsy of the

lesion was performed under anesthesia that included nitrous oxide. The procedure

lasted 45 minutes and the pathology results indicated fibrosarcoma.

>

> The child was taken back to the OR four days later for complete

> resection of the mass. Once again, nitrous oxide-containing anesthesia

> was administered, but this time the procedure lasted 270 minutes. Still, the

patient was discharged on postoperative day 7 in seemingly good health.

>

> Seventeen days after discharge, the infant was admitted to the

> hospital with seizures and apnea episodes. The patient was found to

> be severely hypotonic and CT scan revealed generalized brain atrophy

> with enlarged prepontine and medullary cisterns. In addition, plasma

> methionine levels were low, while homocysteine levels were elevated-

> -both findings consistent with a MTHFR deficiency.

>

> Forty-six days after surgery, the infant died after respiratory arrest.

Postmortem examination showed extensive damage to the

> central nervous system.

>

> Although it was not known at the time of surgery, two of the child's

> relatives had elevated homocysteine levels. However, none had ever

> been treated with nitrous oxide.

>

> The case was initially reported in 1987, but at that time the

> technology was not available to test for MTHFR activity or for

> mutations in the corresponding gene, Dr. W. Erbe, co-author

> of a related editorial, told Reuters Health.

>

> When Dr. Hogan's team went back and tested fibroblast samples from the

> patient and his family, they found a novel MTHFR mutation associated

> with severely decreased enzyme activity.

>

> " I don't think these results should cause panic among the general

> public, " Dr. Erbe, from the University at Buffalo, noted. " There were

> clues in this particular case that suggested a problem before the

> nitrous oxide was given, " he added.

>

> Moreover, the MTHFR mutation in the current case appears to be

> rather rare, Dr. Erbe said. " There is a MTHFR mutation that is present in up

to 50% of the population, but there is no evidence that nitrous oxide is unsafe

for carriers of this mutation. "

>

> However, in children with developmental delay or altered homocysteine

> metabolism, methionine levels should be determined before using

> nitrous oxide-containing anesthesia, he noted.

> Carcinogenesis. 2003 Jun;24(6):1097-103. Epub 2003 Apr 24.

>

> Folate status, metabolic genotype, and biomarkers of genotoxicity in

> healthy subjects. http://www.nejm.org/doi/full/10.1056/NEJMoa021867

>

> And...if someone with this has trouble with efficiently metabolizing folic

acid I would (again) say it's again better to try to support the metabolic

system by whole foods- and try to consume more folic acid in the diet. And

outside of NV which again has 200 mcg of folic acid from whole food per scoop

http://pursuitofresearch.org/ingredients.html you could increase consumption of

eggs, dark leafy vegetables, (spinach and broccoli) oranges and orange juice and

legumes (peas and dried beans)

>

> =====

>

[Guest guest]

What is your doctor's name if you don't mind sharing? There are tons of kids in

this group including mine who have been diagnosed with ADHD -and since about

half of us have this MTHFR mutation (and I believe it can be also stated that

the mutation is normal and the people who don't have this issue are the ones

with the mutation)

Perhaps this explains why NV has shown even more dramatic surges then fish oils

for ADHD, autism and apraxia...but that still doesn't explain the elimination of

seizures does it? I mean we are talking so many different conditions.

When you say your child isn't up to the full dosage of NV...why? Getting the B

vitamins from food again is the purest form of supplementation -the following is

what I pulled really quick -some of the vitamins etc. in NV...again NOT added

-from the list of food ingredients you'll also find at the link

Partial list of nutrients in NV all from whole food -and all water soluble:

50% Vitamin A (retinol palmitate) 2500 IU

100% Vitamin B-1 (thiamine mononitrate) 1.5 mg

100% Vitamin B-2 (riboflavin) 1.7 mg

100% Vitamin B-3 (niacinamide) 20 mg

100% Vitamin B-5 (d-ca pantothenate) 10 mg

100% Vitamin B-6 (pyridoxine) 2 mg

100% Vitamin B-12 (cyanocobalamin) 6 mcg

100% Vitamin C (ascorbic acid) 60 mg

100% Vitamin D-3 (cholecalciferol) 400 IU

100% Vitamin E (d-alpha-tocopherol) 30 IU

100% Folic Acid 400 mcg

10% Biotin 30 mcg

http://pursuitofresearch.org/ingredients.html

I would love to know what your child's doctor said about NV and about using that

in place of individual supplements. This is all interesting. And LOVE this

article

http://www.nypost.com/p/news/national/this_is_your_brain_on_food_uliSUE6b4sfZr8c\

FTo7gRP

=====

[Guest guest]

my daughter has the gene mutation and is on vit b6, vit b complex, b12

injections and will be starting folate soon.....DAN DR put her on these....we

have noticed a HUGE increase in energy levels but nothing with " clearing up her

speech " yet....hopefully the folate will help her....i have 2 other daughter's

(7 yrs and 12 days old) wondering if they have this mutation too?!? my oldest

doesn't show any signs of delays, etc and never has.....my youngest is too young

to tell just yet---12 days old....

> >

> > Something else to know about this gene " defect " that half of us have by the

way " There is a MTHFR mutation that is present in up to 50% of the population "

W. Erbe, M.D., FACMG Professor of Pediatrics and Medicine, University at

Buffalo Chief, Division of Genetics, Women & Children's Hospital ... so..... I'd

get second opinion from a traditional medical doctor as if half of us have some

form of this mutation...one would think you should know this too prior to

" treatment " and if one did want to do treatment again I'd go with food -or check

with an expert in this area such as a Dr. Erbe. This comes up most often for

pregnancy as women don't even know they have this " mutation " (I don't know

-again do you call something a mutation when about half of us have it?!!!) until

they keep having miscarriages.

> >

> > The way to find out if you have this since it appears you can have it and

not know is with a blood test. So if one gets their child tested for this and

they test positive perhaps the mother go for the blood test too and then the

whole family should start eating more folic acid in the diet.

> >

> > And...if someone with this has trouble with efficiently metabolizing folic

acid I would (again) say it's better to consume more folic acid in the diet.

And outside of NV which again has 200 mcg of folic acid from whole food per

scoop http://pursuitofresearch.org/ingredients.html you could increase

consumption of eggs, dark leafy vegetables, (spinach and broccoli) oranges and

orange juice and legumes (peas and dried beans)

> >

> > The only huge thing to be aware of ...and I'm guessing based on the odds of

having this if you are part of the human race -and as they point out -this is

very rare (obviously as I don't know if this happened more than one time?

Warning -very sad tragic story -but again very rare)

> >

> >

> >

> > Nitrous Oxide Anesthesia Implicated in Death of Child With MTHFR

> > Deficiency

> > By J. Brown, MD

> >

> > NEW YORK (Reuters Health) Jul 02 - Nitrous oxide anesthesia

> > administered to a child born with an undiagnosed deficiency in a

> > key metabolic enzyme appears to have caused the child's death,

> > according to a report published in the July 3rd issue of The New

> > England Journal of Medicine.

> >

> > The deficient enzyme, 5,10-methlyenetetrahydrofolate reductase

> > (MTHFR), is involved in the metabolism of folate and in the

> > production of methionine, which is needed for a variety of

> > important biochemical reactions, senior author Dr. Kirk Hogan,

> > from the University of Wisconsin in Madison, and colleagues

> > note.

> >

> > In the current case, because of the enzyme deficiency, the child

> > probably had baseline methionine levels that, although low, were

> > survivable. Unfortunately, in this situation treatment with

> > nitrous oxide, an agent known to block methionine synthesis,

> > may have resulted in fatally low levels.

> >

> > The case involved a male infant who appeared normal until 3 months of

> > age when he presented with a mass in the left leg. Excisional biopsy of the

lesion was performed under anesthesia that included nitrous oxide. The procedure

lasted 45 minutes and the pathology results indicated fibrosarcoma.

> >

> > The child was taken back to the OR four days later for complete

> > resection of the mass. Once again, nitrous oxide-containing anesthesia

> > was administered, but this time the procedure lasted 270 minutes. Still, the

patient was discharged on postoperative day 7 in seemingly good health.

> >

> > Seventeen days after discharge, the infant was admitted to the

> > hospital with seizures and apnea episodes. The patient was found to

> > be severely hypotonic and CT scan revealed generalized brain atrophy

> > with enlarged prepontine and medullary cisterns. In addition, plasma

> > methionine levels were low, while homocysteine levels were elevated-

> > -both findings consistent with a MTHFR deficiency.

> >

> > Forty-six days after surgery, the infant died after respiratory arrest.

Postmortem examination showed extensive damage to the

> > central nervous system.

> >

> > Although it was not known at the time of surgery, two of the child's

> > relatives had elevated homocysteine levels. However, none had ever

> > been treated with nitrous oxide.

> >

> > The case was initially reported in 1987, but at that time the

> > technology was not available to test for MTHFR activity or for

> > mutations in the corresponding gene, Dr. W. Erbe, co-author

> > of a related editorial, told Reuters Health.

> >

> > When Dr. Hogan's team went back and tested fibroblast samples from the

> > patient and his family, they found a novel MTHFR mutation associated

> > with severely decreased enzyme activity.

> >

> > " I don't think these results should cause panic among the general

> > public, " Dr. Erbe, from the University at Buffalo, noted. " There were

> > clues in this particular case that suggested a problem before the

> > nitrous oxide was given, " he added.

> >

> > Moreover, the MTHFR mutation in the current case appears to be

> > rather rare, Dr. Erbe said. " There is a MTHFR mutation that is present in up

to 50% of the population, but there is no evidence that nitrous oxide is unsafe

for carriers of this mutation. "

> >

> > However, in children with developmental delay or altered homocysteine

> > metabolism, methionine levels should be determined before using

> > nitrous oxide-containing anesthesia, he noted.

> > Carcinogenesis. 2003 Jun;24(6):1097-103. Epub 2003 Apr 24.

> >

> > Folate status, metabolic genotype, and biomarkers of genotoxicity in

> > healthy subjects. http://www.nejm.org/doi/full/10.1056/NEJMoa021867

> >

> > And...if someone with this has trouble with efficiently metabolizing folic

acid I would (again) say it's again better to try to support the metabolic

system by whole foods- and try to consume more folic acid in the diet. And

outside of NV which again has 200 mcg of folic acid from whole food per scoop

http://pursuitofresearch.org/ingredients.html you could increase consumption of

eggs, dark leafy vegetables, (spinach and broccoli) oranges and orange juice and

legumes (peas and dried beans)

> >

> > =====

> >