High vitamin E plasma levels and low low-density lipoprotein oxidation are associated with the absence of atherosclerosis in octogenarians.

[Guest guest]

Hi All,

Interesting study which shows that a low level of LDL oxidation is an important

factor in achieving a old age free from

atherosclerosis.

And how to achieve low levels of LDL oxidation? Reduce dietary intakes of mono

and especially poly oils and fats. Here

is my calculation of the oxidative risk for various oils and fats based on the

number of double bonds in the mono and

poly fatty acids in the foods:

crsociety/files/VCO/OilAnalysis291201.gif

The higher the Plaque Formation Index (Oxidation Index), the more likely the LDL

needed to transport the long chain fats

in the blood will be oxidized and elevate plaque formation / growth and

atherosclerosis.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=1\

1380761 & dopt=Abstract

J Am Geriatr Soc 2001 May;49(5):651-4 Related Articles, Books, LinkOut

High vitamin E plasma levels and low low-density lipoprotein oxidation are

associated with the absence of

atherosclerosis in octogenarians.

Cherubini A, Zuliani G, Costantini F, Pierdomenico SD, Volpato S, Mezzetti A,

Mecocci P, Pezzuto S, Bregnocchi M, Fellin

R, Senin U; The VASA Study Group.

Gerontology and Geriatrics, Department of Clinical and Experimental Medicine,

University of Perugia, Perugia, Italy.

OBJECTIVES:

To identify the biological characteristics of older subjects with vascular

successful aging (VASA), defined as the

absence of instrumental signs and clinical symptoms of atherosclerosis in the

extracoronary and coronary vessels.

DESIGN:

A cross-sectional study.

SETTING:

A university-affiliated outpatient clinic.

PARTICIPANTS:

Sixty older subjects (30 with VASA and 30 controls with moderate carotid

atherosclerosis (AG group)) from a sample of

705 subjects age 75 and older consecutively screened.

MEASUREMENTS:

Clinical examination; ultrasonographic examination of carotid, vertebral,

abdominal aortic, iliac, and femoral arteries;

electrocardiogram; and laboratory evaluation (lipid profile, lipophilic

antioxidants, and markers of low-density

lipoprotein (LDL) oxidation).

RESULTS:

Compared with controls, there were more females in the VASA group (82% vs 50%, P

<.01), and fewer previous smokers

(20.5% vs 52.5%, P <.01).

Vitamin E/total cholesterol levels both in plasma (4.81 vs 3.51 micromol/mmol, P

<.001) and in isolated LDLs (2.71 vs

1.86 microg/mg LDL cholesterol (LDL-C), P <.01), were higher in the VASA group,

as was the resistance of LDLs to in

vitro oxidation (as indicated by a longer duration of the lag phase: 80.2 vs

65.6 minutes, P <.001).

The level of fluorescent products of lipid peroxidation (FPLPs) in native LDLs

was lower in the VASA group (13.5 vs 18.8

URF/mg LDL-C, P <.001).

Multivariate logistic regression analysis showed that only plasma vitamin E

level (odds ratio (OR) = 6.04, 95%

confidence interval (CI) = 1.48-24.63) and FPLPs in LDLs (OR = 0.53, 95% CI =

0.31-0.91) were independently associated

with VASA.

CONCLUSIONS:

These results suggest that an appropriate level of vitamin E and a low level of

LDL oxidation might be important for

reaching advanced age without developing atherosclerosis.

PMID: 11380761 [PubMed - indexed for MEDLINE]

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Good Health & Long Life,

Greg , gowatson@...

USDA database (food breakdown) http://www.nal.usda.gov/fnic/foodcomp/

PubMed (research papers) http://www.ncbi.nlm.nih.gov/entrez/query.fcgi

DWIDP (nutrient analysis) http://www.walford.com/dwdemo/dw2b63demo.exe

Patch file for above http://www.walford.com/download/dwidp67u.exe

KIM (omega analysis) http://ods.od.nih.gov/eicosanoids/KIM_Install.exe