Dietary polyunsaturated fatty acids and composition of human aortic plaques.

[Guest guest]

Hi All,

Interesting paper published in the Lancet. Note the line: " No associations were

found with saturated fatty acids. "

So again we see more solid data linking BOTH mono and poly fatty acids with

plaque formation but NOT saturated fatty

acids. Note the association climbs as the number of double bonds increases.

3 double bonds, Omega 3 = 0.93,

2 double bonds, Omega 6 = 0.75

1 double bond, Mono = 0.70

0 double bonds, Sat = 0.00

The reason? Sat fats can't be oxidized and mono and poly can be. Again I

suggest you have a close look at the analysis

I have done, especially at the Plaque formation index verus the amount of double

bond rich fatty acids in the various

common food oils and fats.

crsociety/files/VCO/OilAnalysis291201.gif

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve & db=PubMed & list_uids=7\

934543 & dopt=Abstract

Lancet 1994 Oct 29;344(8931):1195-6 Related Articles, Books, LinkOut

Dietary polyunsaturated fatty acids and composition of human aortic plaques.

Felton CV, Crook D, Davies MJ, Oliver MF.

Wynn Institute for Metabolic Research, London, UK.

How long-term dietary intake of essential fatty acids affects the fatty-acid

content of aortic plaques is not clear.

We compared the fatty-acid composition of aortic plaques with that of

post-mortem serum and adipose tissue, in which

essential fatty-acid content reflects dietary intake.

Positive associations were found between serum and plaque omega 6 (r = 0.75) and

omega 3 (r = 0.93) polyunsaturated

fatty acids, and monounsaturates (r = 0.70), and also between adipose tissue and

plaque omega 6 polyunsaturated fatty

acids (r = 0.89).

No associations were found with saturated fatty acids.

These findings imply a direct influence of dietary polyunsaturated fatty acids

on aortic plaque formation and suggest

that current trends favouring increased intake of polyunsaturated fatty acids

should be reconsidered.

PMID: 7934543 [PubMed - indexed for MEDLINE]

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Good Health & Long Life,

Greg , http://optimalhealth.cia.com.au gowatson@...

USDA database (food breakdown) http://www.nal.usda.gov/fnic/foodcomp/

PubMed (research papers) http://www.ncbi.nlm.nih.gov/entrez/query.fcgi

DWIDP (nutrient analysis) http://www.walford.com/dwdemo/dw2b63demo.exe

Patch file for above http://www.walford.com/download/dwidp67u.exe

KIM (omega analysis) http://ods.od.nih.gov/eicosanoids/KIM_Install.exe