Re: Mitochondrial Dysfunction in Autism and Other Disorders, Can Diet Help?

[Guest guest]

, I started reading about mito disorders a while back, because most are

accompanied by muscle tone issues. Turns out many of the mito disorders are

treated with carnitine. I haven't looked at the NV bottle lately to see if it

has carnitine added. In any case, if you research carnitine there have been

studies showing soy formula without carnitine added resulted in disorders of fat

metabolism. I thought this was especially interesting, given that many of us

are treating the apraxia with fats!

My nutritionist, whom I've used for years, maintains carnitine levels could

improve naturally with improved protein digestion. I only have my own progress

to back that up. Otherwise, you're left with carnitine supplementation.

So yes, it's all a very curious circle.

On Dec 10, 2010, at 6:10 PM, kiddietalk wrote:

> The following was inspired by one of the questions from here!

>

> Mitochondrial Dysfunction in Autism and Other Disorders, Can Diet Help?

>

> Someone in our nonprofit group just asked " My Aunt sent me an article about

research that found children with autism have mitochondrial problems. I know

people in this group know so much so just curious if we are supposed to test for

this? And if so what do you do for it? "

>

> Great question! The study probably shared was the one that was just published

in the December 1 issue of the Journal of the American Medical Association;

`Mitochondrial Dysfunction in Autism' led by Cecilia Giulivi, PhD. 1 The study

found that it was more common in children with autism to have mitochondrial

dysfunction or deficits mitochondrial DNA (mtDNA) abnormalities, including

overreplication and deletions in children with autism than in typically

developing children.

>

> According to Isaac Pessah, director of the Center for Children's Environmental

Health and Disease Prevention, a UC MIND Institute researcher and

professor of molecular biosciences at the UC School of Veterinary Medicine

" The various dysfunctions we measured are probably even more extreme in brain

cells, which rely exclusively on mitochondria for energy " 2

>

> While this study was completed with just 20 children, 10 of them with severe

autism, there is much research that links mitochondrial dysfunction to several

neurological conditions, including Parkinson's disease, Alzheimer's disease,

schizophrenia, and bipolar disorder.

>

> Read more (and watch videos) at

>

>

http://pursuitofresearch.com/2010/12/10/mitochondrial-dysfunction-in-autism-and-\

other-disorders-can-diet-help/

>

> =====

>

[Guest guest]

Hi !

I know it's all so interesting how it seems there are so many different

theories, different diagnosis- and yet there are tiny little links that circle

them together.

Nutriiveda contains all of the essential amino acids which is what is most

important because the body can't produce them; needs to consume them. The body

can produce carnitine because it's not an essential amino acid and it's produced

with the essential amino acids lysine and methionine; both of which are

naturally found in NV from the protein food source.

The problem outside of NV is that sometimes we don't get enough protein or even

if we do we don't consume all of the essential amino acids daily or the body

can't utilize what we consume. Some proteins are harder to digest than others.

Meat for example is harder to digest than say whey isolate protein which is

already partially broken down. The purest way to supplement and the most easily

digestible is from food. So that may be why Nutriiveda is working -because it's

clearly not just working on one area of the body. At this point I have covered

a number of nutrients in it that may explain what we are seeing. I know from

this group that we have a higher number of members who have children with

primary or secondary carnitine deficiency and it's most important to get the

child tested prior to that supplementation because if there is a deficiency you

want to know. It is recommended to take the child to a geneticist who

specializes in metabolic disorders and get the prescription carnitine for purity

and quality reasons. The reason is just what you said. Carnitine affects the

muscles -but when you supplement you may or may not notice a difference in any

way. But carntine affects all the muscles in the body -including those around

the heart and chronic carnitine deficiency is one of those rare things that

typically was found during autopsy -as it is linked to sudden death

http://emedicine.medscape.com/article/942233-overview Not something that is

nice to talk about -but sure better to know sooner rather than later for

preventative reasons. Carnitine was the reason I put my son Tanner through

extensive metabolic testing. I highly suggest all test for carnitine deficiency

-you'll have to ask for it because it's not a typical blood test. Tanner's

pediatrician ordered the test and it was covered by our insurance. Tanner's

results were normal but again in this group if you check the archives the amount

that had children that tested borderline or low is quite high given the norm is

1 in 40 thousand is typically deficient in carnitine.

After all we tend to be the instant gratification society so if a doctor or some

other parent who isn't knowledgeable about this area recommends you try

carnitine supplements and you don't test first you will possibly skew the

results even if you do test after. And if you use the supps for awhile and then

just stop as we do as parents -you won't know if it's important to keep

monitoring the levels as again you may not notice any difference at all from the

outside -but it's what is going on inside that counts.

Nutriiveda is easily digestible again; and it's not supplementing carnitine as

all the ingredients are food. So...if it helps the body produce carnitine, then

that's awesome. We really don't know if that is why it's helping our children

but I suspect it is far more because in our group even those who have children

with carnitine deficiency once supplemented don't really report dramatic surges

for the most part that we are seeing with NV

http://pursuitofresearch.com/pursuit-of-research/

I believe for sure your nutritionist is correct because improved protein

digestion would help with utilizing and producing any amino acid needed

Who knew having a kid you'd have to do the work to get a degree in so many

fields, special ed law, neurology, education, genetics, biology, sign language,

nutrition (how much more can we go on???)

So yes, I agree, it's all a very curious circle.

=====

[Guest guest]

What kind of test is done for a mitochondrial dysfunction?

Noelle

Sent from my iPhone

On Dec 10, 2010, at 7:10 PM, Claggett <schoolonthehill@...

> wrote:

> , I started reading about mito disorders a while back, because

> most are accompanied by muscle tone issues. Turns out many of the

> mito disorders are treated with carnitine. I haven't looked at the

> NV bottle lately to see if it has carnitine added. In any case, if

> you research carnitine there have been studies showing soy formula

> without carnitine added resulted in disorders of fat metabolism. I

> thought this was especially interesting, given that many of us are

> treating the apraxia with fats!

>

> My nutritionist, whom I've used for years, maintains carnitine

> levels could improve naturally with improved protein digestion. I

> only have my own progress to back that up. Otherwise, you're left

> with carnitine supplementation.

>

> So yes, it's all a very curious circle.

>

>

> On Dec 10, 2010, at 6:10 PM, kiddietalk wrote:

>

> > The following was inspired by one of the questions from here!

> >

> > Mitochondrial Dysfunction in Autism and Other Disorders, Can Diet

> Help?

> >

> > Someone in our nonprofit group just asked " My Aunt sent me an

> article about research that found children with autism have

> mitochondrial problems. I know people in this group know so much so

> just curious if we are supposed to test for this? And if so what do

> you do for it? "

> >

> > Great question! The study probably shared was the one that was

> just published in the December 1 issue of the Journal of the

> American Medical Association; `Mitochondrial Dysfunction in Autism'

> led by Cecilia Giulivi, PhD. 1 The study found that it was more

> common in children with autism to have mitochondrial dysfunction or

> deficits mitochondrial DNA (mtDNA) abnormalities, including

> overreplication and deletions in children with autism than in

> typically developing children.

> >

> > According to Isaac Pessah, director of the Center for Children's

> Environmental Health and Disease Prevention, a UC MIND

> Institute researcher and professor of molecular biosciences at the

> UC School of Veterinary Medicine " The various dysfunctions we

> measured are probably even more extreme in brain cells, which rely

> exclusively on mitochondria for energy " 2

> >

> > While this study was completed with just 20 children, 10 of them

> with severe autism, there is much research that links mitochondrial

> dysfunction to several neurological conditions, including

> Parkinson's disease, Alzheimer's disease, schizophrenia, and bipolar

> disorder.

> >

> > Read more (and watch videos) at

> >

> >

http://pursuitofresearch.com/2010/12/10/mitochondrial-dysfunction-in-autism-and-\

other-disorders-can-diet-help/

> >

> > =====

> >

[Guest guest]

lisa, thanks for sharing this piece. sean has a chromosomal duplication (of " no

known syndrome " ) but certainly is at the root of his challenges so studies like

these are always of interest.. again, thanks for sharing even if studies or

testing don't give you an " answer " (our testing did not) they all help build

toward path(s) to explore. judy

[ ] Mitochondrial Dysfunction in Autism and Other

Disorders, Can Diet Help?

The following was inspired by one of the questions from here!

Mitochondrial Dysfunction in Autism and Other Disorders, Can Diet Help?

Someone in our nonprofit group just asked " My Aunt sent me an article about

research that found children with autism have mitochondrial problems. I know

people in this group know so much so just curious if we are supposed to test for

this? And if so what do you do for it? "

Great question! The study probably shared was the one that was just published in

the December 1 issue of the Journal of the American Medical Association;

`Mitochondrial Dysfunction in Autism' led by Cecilia Giulivi, PhD. 1 The study

found that it was more common in children with autism to have mitochondrial

dysfunction or deficits mitochondrial DNA (mtDNA) abnormalities, including

overreplication and deletions in children with autism than in typically

developing children.

According to Isaac Pessah, director of the Center for Children's Environmental

Health and Disease Prevention, a UC MIND Institute researcher and

professor of molecular biosciences at the UC School of Veterinary Medicine

" The various dysfunctions we measured are probably even more extreme in brain

cells, which rely exclusively on mitochondria for energy " 2

While this study was completed with just 20 children, 10 of them with severe

autism, there is much research that links mitochondrial dysfunction to several

neurological conditions, including Parkinson's disease, Alzheimer's disease,

schizophrenia, and bipolar disorder.

Read more (and watch videos) at

http://pursuitofresearch.com/2010/12/10/mitochondrial-dysfunction-in-autism-and-\

other-disorders-can-diet-help/

=====