Regimen Changes provoked by *Laboratory Evaluations in Molecular Medicine*

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In a message dated 5/13/02 10:18:22 PM Eastern Daylight Time,

fskelton@... writes:

and Av: There's been a couple of requests for you to give some

examples

of how the book *Laboratory Evaluations in Molecular Medicine* (For more

see www.metametrix.com) you recommended changed your CR regimen (as you

previously hinted).

Francesa,

Thanks for waking us up. Due to an unusually heavy work schedule, we weren't

on the support list much, but when we looked, we did not see the requests.

We are sending this to both Lists so hopefully all who are interested will

see it.

Here are some examples:

Cholesterol/HDL ratio

In the Chapter on EFA the authors give tips on fatty acid intake and how, in

the absence of some good dietary fat, the liver converts carbs or protein to

palmitic acid. As many know, palmitic is a saturated FA and the FA most

readily converted by the liver into cholesterol. According to the authors,

absence of good dietary fat generally results in high plasma concentrations

of saturated fatty acids--not what a Cronie wants!

This has caused us to balance our meals with high quality fat sources a

little more carefully. Just adding 5 g walnuts to 's morning detox

regimen has resulted in a postprandial Cholesterol/ HDL ratio of 2/1

(measured at home by the Bioscanner 2000)--the optimal result he had

targeted.

Averill is eating almonds and walnuts more intentionally to balance the fat

types and macronutrients better.

Amino Acids

The chapter on amino acids gives a detailed description of the many

functions of amino acids, a subject Dr. Lord did research on as an NIH

fellow. The section on arginine was of practical value to us when the text

warned against eating too many high lysine foods such as meat and dairy

products and pointed out that arginine-supplying foods such as beans and

nuts are important for a whole host of benefits including better HDL/LDL

profiles and enhanced gut detoxification.

This has resulted in a more careful balance of protein sources especially

for morning detox. And an actual reduction in protein in Averill's case.

The authors provide a table giving common clinical presentations that

indicate a need for amino acid assessment.

Included are:

o Weight control by severe dietary restriction

o Rapid weight loss

Obviously an amino acid assessment could be important to CR practitioners,

some of whom may not be realizing the full potential of their CR simply

because of their protein choices.

Detoxification

The chapter on GI function describes clearly how the lining of the

intestinal tract is challenged by undigested food. Poorly processed food can

result in increased intestinal permeability and eventually cause immune

reactions to certain foods.

The deep description provided in these pages persuaded to change his

eating habits for his lunchtime meal. Consider his day--he is bombarded

literally every five minutes by people who want his attention--phone calls,

interviews, reporting staff, etc. This creates terrible pressure to eat

lunch as quickly as possible, not chewing foods properly and setting himself

up for the very type of immune challenges described here. Now he sequesters

himself, giving him time to eat his meal in a less hurried fashion.

Averill, on the other hand, has long been famous among family and friends as

a slow eater. This turns out to be good, of course, and may account for her

" cast-iron " GI system that can take anything she gives it--very al dente

legumes for example--with no bad effects.

and Averill

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