Scientists Create Autism-Like Traits in Mice

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Scientists Create Autism-Like Traits in Mice

Gene manipulation produces common behaviors and provides model for testing

drugs, expert says

MONDAY, March 21 (HealthDay News) -- Scientists report that mutating a single

gene produced mice with two of the most common autism traits, a finding they say

could one day lead to the development of drugs to treat autism.

Currently, there are no effective drugs to treat the disorder.

Mutating the shank3 gene led to compulsive repetitive behavior and avoidance of

social interaction in the mice, apparently caused by impaired communication

between brain cells, said the researchers at Duke University and the McGovern

Institute for Brain Research at the Massachusetts Institute of Technology.

The shank3 gene has been implicated in human autism.

The study was published online March 20 in Nature.

" We now have a very robust model with a known cause for autistic-like

behaviors, " senior author Guoping Feng, a professor of brain and cognitive

sciences at MIT, said in a McGovern Institute news release. " We can figure out

the neural circuits responsible for these behaviors, which could lead to novel

targets for treatment. "

The genetically altered mice also provide a way to assess experimental autism

drugs before they're tested in humans.

Scientists acknowledge that research involving animals often fails to result in

beneficial treatments for humans.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about

autism.