Centenarian update

[Guest guest]

Hi All, Here is an update on centenarian posts.

I comment on the first and maybe best. I like it. Seems like lipid control

and maybe Alzheimer’s disease avoidance are important. CRONies keep their

brain lights on too, I think.

“RESULTS: Elders (94 nonagenarians, 6 centenarians) manifested preserved

cognition, as reflected by clinical and psychometric assessments; " good "

average capacity to carry out their activities of daily living; and the

majority were living independently despite multiple medical conditions. None

had a history of mental disorders in early or middle adulthood, only one was

a current smoker, and 80% consumed alcohol less than once each month. The

genome survey method detected the expected elevation of the APOE”

(Apolipoprotein [Any of various proteins that combine with a lipid to form a

lipoprotein and are a constituent of chylomicrons, HDL, LDL, and VLDL]

“E”

(An apolipoprotein found in VLDL, HDL, chylomicrons, and chylomicron

remnants. Elevated in individuals with type III hyperlipoproteinaemia.),

“a genetic risk factor for Alzheimer's disease) epsilon2 allele frequency,

and reciprocal reduction in the epsilon4 frequency, among the elders,

compared with the young adults. ….. CONCLUSIONS: These results suggest that

several behavioral and genetic factors may contribute to the likelihood of

achieving exceptional longevity with preserved cognition.”

PMID: 12213697 [PubMed - in process]

“CONCLUSIONS In centenarians 24-h blood pressure values are: (1) lower than

sphygmomanometric blood pressures and (2) slightly less than in subjects

aged 80 years. At variance with these subjects, however, in centenarians

nocturnal hypotension and bradycardia are abolished, presumably because of a

derangement in the central sleep influences on the cardiovascular system.”

PMID: 12195117 [PubMed - as supplied by publisher]

“Although TNF-alpha is likely to be involved in the pathogenesis of

atherosclerosis and dementia, the present study does not support the

hypothesis that TNF-alpha represents a link between chronic C. pneumoniae

infection and these disorders.”

PMID: 12195874 [PubMed - in process]

Cheers, Al.

Alan Pater, Ph.D.; Faculty of Medicine; Memorial University; St. 's, NF

A1B 3V6 Canada; Tel. No.: (709) 777-6488; Fax No.: (709) 777-7010; email:

apater@...