RE: Alzheimer's and calorie restriction

[Guest guest]

Hi All,

Sure.

Cheers, Al.

Caloric Intake and the Risk of Alzheimer Disease

Arch Neurol. 2002;59:1258-1263 A. Luchsinger, MD; Ming-Xing Tang, PhD; Shea, MD; Mayeux, MD

Abstract:

Background Diet may play a role in Alzheimer disease (AD).

Objective To examine the association between caloric intake and AD.

Methods Elderly individuals free of dementia at baseline (N = 980) were followed for a mean of 4 years. Daily intake of calories, carbohydrates, fats, and protein were recalled using a semiquantitative food frequency questionnaire administered between the baseline and first follow-up visits. Proportional hazards models were used to examine the associations of quartiles of intake and incident AD, adjusting for confounders.

Results There were 242 incident cases of AD during 4023 years of follow-up (6 cases per 100 person-years). Compared with individuals in the lowest quartile of caloric intake, those in the highest quartile had an increased risk of AD (hazard ratio, 1.5; 95% confidence interval [CI], 1.0-2.2). Among individuals with the apolipoprotein E 4 allele, the hazard ratios of AD for the highest quartiles of calorie and fat intake were 2.3 (95% CI, 1.1-4.7) and 2.3 (95% CI, 1.1-4.9), respectively, compared with the lowest quartiles. The hazard ratios of AD for the highest quartiles of calorie and fat intake compared with the lowest quartiles in individuals without the apolipoprotein E 4 allele were close to 1 and were not statistically significant (P = .83 and P = .61, respectively).

Conclusion Higher intake of calories and fats may be associated with higher risk of AD in individuals carrying the apolipoprotein E 4 allele.

PMID: 12164721 [PubMed - in process]

-----Original Message-----From: Francesca Skelton [mailto:fskelton@...]Sent: Thursday, August 15, 2002 9:17 AM Subject: Re: [ ] Alzheimer's and calorie restrictionIris: I had trouble getting this long link to work. Saw this also in thisam's Washington Post but can't find the article on-line. Al Pater: wouldyou be so kind as to dig up the article? Reported in this month's "Archivesof Neurology".

[Guest guest]

Iris: I had trouble getting this long link to work. Saw this also in this

am's Washington Post but can't find the article on-line. Al Pater: would

you be so kind as to dig up the article? Reported in this month's " Archives

of Neurology " .

on 8/14/2002 11:29 PM, oc9 at ibap@... wrote:

> The following article sites calorie restriction and low fat diets as

> reducing Alzheimer's risk in " susceptible individuals " . Most of us,

> I'm sure, don't know whether we're carrying the genes they discuss or

> not. But the gene isn't a 100% predictor either.

>

> http://story.news./news?

> tmpl=story & ncid=594 & e=5 & cid=594 & u=/nm/20020814/hl_nm/alzheimers_risk_d

> c_1

>

> Iris

>

>

>

>