Re: Science article

[Guest guest]

Joe, Very interesting study. I'm new to the group and have been on a CR diet

for about two weeks. I'm interested in the bio-markers you mentioned. What

is DHEAS and what is considered a low body temperature and a high body

temperature. Also, is there any easy, at home way to measure insulin

sensitivity? Thanks Rob

>From: " joesmad2001 " <fernaj@...>

>Reply-

>

>Subject: [ ] Science article

>Date: Fri, 02 Aug 2002 18:32:34 -0000

>

>All,

>

>Today's Scientific Journal Science has an article " Biomarkers of

>Calorie Restriction May Predict Longevity in Humans " Vol 297, August

>2, 2002 Page 811.

>

>It discusses linking biomarkers in the Rhesus Monkey study and the

>Baltimore Longitudial Study of Aging (BLSA) which. I shows some

>simple bar graphs on CR and control Monkeys for body temp, insulin,

>and DHEAS (which decreases in humans and monkeys as they age and may

>be a biomarker of aging). It also shows BLSA data for these three

>biomarkers. Briefly, BLSA men were separated into upper and lower

>groups depending what their Biomarkers were (example, those with

>higher body temp were grouped in the higher cat). These men were not

>on CR but exibited " CR biomarkers.

>

>Bottom line is the survival curve (up to 25 years) for the BLSA study

>was higher for the lower body temp, lower insulin, and higher DHEAS

>groups which is exactly what the Rhesus monkey indicates. Therefore

>the Rhesus monkey results appear to have a direct correlation to

>humans, as far the biomarkers go. THe article does note that the

>Rhesus monkeys on CR have half the mortality rate as the control

>animals but this may not be statistically significant yet.

>

>Joe

>

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