Hormone replacement therapy and CR

[Guest guest]

Hi All,

In a PDF available not yet in Medline article in European Journal of

Nutrition, Volume 41 Issue 3 (2002) pp 101-107 article attached, I just

thought the ladies might like this so much. It unfortunately is of no

interest directly to me, although it suggests maybe even the benefits of CR

affect the need for male hormones.

Cheers, Al.

Alan Pater, Ph.D.; Faculty of Medicine; Memorial University of Newfoundland;

St. 's, NF A1B 3V6 Canada; Tel. No.: (709) 777-6488; Fax No.: (709)

777-7010; email: apater@...

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European Journal of Nutrition

ISSN: 1436-6207 (printed version)

ISSN: 1436-6215 (electronic version)

Table of Contents

Abstract Volume 41 Issue 3 (2002) pp 101-107

DOI 10.1007/s003940200015

original contribution: The efficacy of dietary

intervention

alone or combined with hormone replacement therapy in

postmenopausal women with hypercholesterolemia in Seoul,

Korea

Kyungah Jung (1), Sangyeon Kim (2), Jeongik Woo (3),

Yookyung

Chang (4)

(1) Korean Living Science Research Institute, Hanyang

University, 17 Haengdang-dong Sungdong-ku, Seoul,

133-791,

Korea Tel.: +82-2/2290-1207 Fax: +82-2/2290-1846 E-Mail:

kaj0417@...

(2) KODITION R & D center, 9F Yoosung Bldg, 830-67

Yeaksam-dong,

kangnam-gu, Seoul, 135-936, Korea

(3) Department of Family Medicine, Miz Medi Hospital,

1021-4

Daechi-dong, Kangnam-ku, Seoul, 135-280, Korea

(4) Department of Food and Nutrition, Hanyang University,

17

Haengdang-dong Sungdong-ku, Seoul, 133-791, Korea

Received: 16 July 2001, Accepted: 18 February 2002

Summary Background Women have an increased incidence of

[image]cardiovascular disease (CVD) due to hormone

imbalance-induced

changes in blood lipid profiles after menopause. Aim of

study

This study was done to compare the effects of dietary

intervention and hormone replacement therapy, alone or in

combination, on blood lipids and body weight in Korean

postmenopausal women with hypercholesterolemia. Method

The

subjects were treated by one of three different

treatments for

12 weeks: hormone replacement therapy (HRT group, n = 8),

dietary intervention (DIET group, n = 8) and hormone

replacement therapy combined with dietary intervention

(HRT+DIET group, n = 8). Results Serum TC and LDL-C

levels

decreased by 13-16 % and 24-28 % in the HRT group, by

17-19 %

and 21-23 % in the DIET group and by 19-26 % and 32-39 %

in the

HRT+DIET group, respectively (P < 0.05). Serum HDL-C

levels

decreased in the DIET group (-6.4 %, P < 0.05) but not in

the

HRT and HRT+DIET groups. Serum TG levels increased in the

HRT

group (18 %, P < 0.05) but decreased in the DIET group

(-24.4

%, P < 0.05). In the HRT+ DIET group, serum TG levels did

not

change. Body weight decreased only in the DIET group.

Conclusions We can conclude that dietary intervention

produces

a considerable improvement in blood lipid profiles and

body

weight, even though our study is limited by the sample

size.

Thus, the treatment to reduce risk of CVD should be

individualized on the basis of the patient's dietary

intake

status, and at least, HRT should not be substituted for

dietary

intervention.

Key words hypercholesterolemia - postmenopausal women -

hormone

replacement therapy - dietary intervention - lipid level

Article in PDF format (248 KB)

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Online publication: June 24, 2002

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