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OT- Dog treatment toxic?

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I was wondering if anyone know if a topical dog treatment we use which is

made by Pfizer and called Revolution which is a heart worm and tick parasite

treatment could be toxic. The active ingredient is selamectin which

contains

(5Z,25S)-25-cyclohexyl-4'-O-de(2,6-dideoxy-3-0-methyl-sigma-L-arabino-hexopy

ranoayl)-5-demethoxy-25-de(1-methylpropyl)-22,23-dihydro-5-hydroxyiminoaverm

ectin A1a. If this is toxic, does anyone know of a less toxic treatment?

Thanks!

Dave

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