Tech: Bisphosphonates and risk of dying

October 7, 2002

Oops, here is the abstract, All.

Cheers, Al.

Alan Pater, Ph.D.; Faculty of Medicine; Memorial University; St. 's, NF

A1B 3V6 Canada; Tel. No.: (709) 777-6488; Fax No.: (709) 777-7010; email:

apater@...

1: Circulation 2002 Sep 10;106(11):1327-32

Dose response of almonds on coronary heart disease risk factors: blood lipids,

oxidized low-density lipoproteins, lipoprotein(a), homocysteine, and pulmonary

nitric oxide: a randomized, controlled, crossover trial.

DJ, Kendall CW, Marchie A, TL, Connelly PW, Qian W, Haight JS,

Faulkner D, Vidgen E, Lapsley KG, Spiller GA.

Clinical Nutrition and Risk Factor Modification Center, St 's Hospital,

Toronto, Ontario, Canada. cyril.kendall@...

BACKGROUND: Although recent studies have indicated that nut consumption may

improve levels of blood lipids, nuts are not generally recommended as snacks for

hyperlipidemic subjects because of their high fat content. Furthermore, the

effective dose is still unknown. METHODS AND RESULTS: The dose-response effects

of whole almonds, taken as snacks, were compared with low-saturated fat (<5%

energy) whole-wheat muffins (control) in the therapeutic diets of hyperlipidemic

subjects. In a randomized crossover study, 27 hyperlipidemic men and women

consumed 3 isoenergetic (mean 423 kcal/d) supplements each for 1 month.

Supplements provided 22.2% of energy and consisted of full-dose almonds (73+/-3

g/d), half-dose almonds plus half-dose muffins, and full-dose muffins. Fasting

blood, expired air, blood pressure, and body weight measurements were obtained

at weeks 0, 2, and 4. Mean body weights differed <300 g between treatments. The

full-dose almonds produced the greatest reduction in levels of blood lipids.

Significant reductions from baseline were seen on both half- and full-dose

almonds for LDL cholesterol (4.4+/-1.7%, P=0.018, and 9.4+/-1.9%, P<0.001,

respectively) and LDL:HDL cholesterol (7.8+/-2.2%, P=0.001, and 12.0+/-2.1%,

P<0.001, respectively) and on full-dose almonds alone for lipoprotein(a)

(7.8+/-3.5%, P=0.034) and oxidized LDL concentrations (14.0+/-3.8%, P<0.001),

with no significant reductions on the control diet. No difference was seen in

pulmonary nitric oxide between treatments. CONCLUSIONS: Almonds used as snacks

in the diets of hyperlipidemic subjects significantly reduce coronary heart

disease risk factors, probably in part because of the nonfat (protein and fiber)

and monounsaturated fatty acid components of the nut.

Publication Types:

Clinical Trial

Randomized Controlled Trial

PMID: 12221048 [PubMed - indexed for MEDLINE]

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