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Hi there,

Did anyone report leg stiffness soon 2 or 3 days after starting LDN at 3 mg?

I am trying to help someone else just started 3 days ago. He is happy noticing his legs firmer, but worried about this feeling. I know that this is a typical side effect of a dose that might be a bit strong and if the problem persists over 2 weeks, it might be the case of reducing dosage…

Did anyone have the same problem? How long did it last? Was it necessary to reduce the dosage after all?

Another question on the behalf of another person…does anyone know if Naltrexone is compatible with the following drugs?

Neurontin, Laroxil and Valium.

Thanks,

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Hi Massimo

I've been on 3mg LDN for nearly two weeks now, and I can also report that I had some leg stiffness for the first few days. Perhaps still have it now as well, to a lesser extent.

Particularly when I wake up, my legs much more "rigid" than normal. It doesn't take much stumbling around before they loosen up though, it certainly didn't persist all day. It's a normal side effect at the start of treatment as far as I know, and it has lessened.

Dr Lawrence recommends taking it one day, then missing a day, until the stiffness subsides if it's bad, but I didn't bother. I want all the benefit, right now! ;-) Personally I'd just keep going on them! As Larry has just said, there's a fear factor in there as well. Any new feeling is worrying.

I'm loving it though, this far in I'm feeling better. Even went for a brief walk earlier.

Regarding your second question, Neurontin is "gabapentin" which is an anticonvulsant (originally). It is not a narcotic AFAIK. Valium is a nervous system depressant, again not a narcotic. I don't know about Laroxil I'm afraid - and a quick google search didn't yield anything.

I would emphasize that I don't know what I'm talking about and anyone on any drug when considering taking LDN should check with their prescribing physician.

Matt

-----Original Message-----From: Max [mailto:maxbtm@...]Sent: 18 June 2003 13:25Spotlight_ldn Cc: low dose naltrexone Subject: [low dose naltrexone] LDN starters__help

Hi there,

Did anyone report leg stiffness soon 2 or 3 days after starting LDN at 3 mg?

I am trying to help someone else just started 3 days ago. He is happy noticing his legs firmer, but worried about this feeling. I know that this is a typical side effect of a dose that might be a bit strong and if the problem persists over 2 weeks, it might be the case of reducing dosage…

Did anyone have the same problem? How long did it last? Was it necessary to reduce the dosage after all?

Another question on the behalf of another person…does anyone know if Naltrexone is compatible with the following drugs?

Neurontin, Laroxil and Valium.

Thanks,

Massimo

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Hi Matt, & Massimo & all:

I have been on LDN 6 wks. My legs are not as stiff any more! yea!! I went out without my cane today. I seem to be walking much better. Energy is very good, & I am sleeping much better. My spasms don't seem to be as bad either. I still have some foot cramps, but not as often. I have remained on 3 mg. all along, & that is probably where I will stay. I am in for duration. I did expercience heavyness in rt.ft. and leg for while, now seems to be getting much better. I just take my pill every night, and forget about the rest of possible side effects.I also have more range of motion in rt. ft. now. yea!! So, my thoughts are, stay with LDN forever. Find your nitch in dosage and hang in there! I do appreciate this group. One does not feel all alone in the MS world. Keep thinking possitive thoughts. The best is yet to come. Share a smile with someone, make them happy! :)

Regards, Cydney

-----Original Message-----From: Matt Dixon [mailto:matt_j_dixon@...] Sent: Wednesday, June 18, 2003 6:04 AMMax; Spotlight_ldn Cc: low dose naltrexone Subject: RE: [low dose naltrexone] LDN starters__help

Hi Massimo

I've been on 3mg LDN for nearly two weeks now, and I can also report that I had some leg stiffness for the first few days. Perhaps still have it now as well, to a lesser extent.

Particularly when I wake up, my legs much more "rigid" than normal. It doesn't take much stumbling around before they loosen up though, it certainly didn't persist all day. It's a normal side effect at the start of treatment as far as I know, and it has lessened.

Dr Lawrence recommends taking it one day, then missing a day, until the stiffness subsides if it's bad, but I didn't bother. I want all the benefit, right now! ;-) Personally I'd just keep going on them! As Larry has just said, there's a fear factor in there as well. Any new feeling is worrying.

I'm loving it though, this far in I'm feeling better. Even went for a brief walk earlier.

Regarding your second question, Neurontin is "gabapentin" which is an anticonvulsant (originally). It is not a narcotic AFAIK. Valium is a nervous system depressant, again not a narcotic. I don't know about Laroxil I'm afraid - and a quick google search didn't yield anything.

I would emphasize that I don't know what I'm talking about and anyone on any drug when considering taking LDN should check with their prescribing physician.

Matt

-----Original Message-----From:[mai l Max lto:maxbtm@...]Sent: 18 June 2003 13:25Spotlight_ldn Cc: low dose naltrexone Subject: [low dose naltrexone] LDN starters__help

Hi there,

Did anyone report leg stiffness soon 2 or 3 days after starting LDN at 3 mg?

I am trying to help someone else just started 3 days ago. He is happy noticing his legs firmer, but worried about this feeling. I know that this is a typical side effect of a dose that might be a bit strong and if the problem persists over 2 weeks, it might be the case of reducing dosage…

Did anyone have the same problem? How long did it last? Was it necessary to reduce the dosage after all?

Another question on the behalf of another person…does anyone know if Naltrexone is compatible with the following drugs?

Neurontin, Laroxil and Valium.

Thanks,

Massimo

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