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This is interesting because I missed a few days between the last pill I took from my first supply and the time that I received my new supply in the mail. I missed 3 days. Oddly enough, I felt really good those 3 days and wondered why. I thought I'd feel really bad.

-----Original Message-----From: LarryGC [mailto:larrygc@...]Sent: Wednesday, May 14, 2003 12:46 PMLDN group; Spotlight_MedSubject: [low dose naltrexone] "Missing" dosesI was reading old old newsgroup messages and I found someone saying he wasn'ttaking LDN every day. Something like 14 days on, and 3? days off? or 21 dayson? I'm not sure of the skipped days.Does anyone take only 6 a week, and skip one night a week? Or anything otherthan 1 a day?Would there be any benefit, or reason, behind not taking it every day?The other question would be, if anyone missed the 9pm-3am window and thereforemissed a day unintentionally, have you noticed any affects that very next day?

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The doctor prescribing my LDN has suggested taking it for 14 days and

missing 3. Below is a quote from his notes:

" Intermittent Therapy: When a drug is used for a prolonged period of

treatment, even at the very low dose as used in this circumstance, it

remains possible that the body will slowly adjust to the continuous presence

of the drug, when the response to that drug will eventually diminish. This

process is referred to as accommodation, when the body eventually develops a

tolerance to the drug.

In addition, as a result of this process of accommodation, continuous use of

a drug will also create a situation of dependency. In this circumstance,

what was previously considered to be a normal state of physiological

activity (in this case, the level of brain endorphins produced) will become

dependent upon the continuing presence of the drug.

To prevent this situation developing, and contrary to the advice suggested

by Dr Bihari, it is considered advisable to use a form of intermittent

therapy. Initially, the suggested routine was to take the naltrexone each

day for three weeks, after which treatment was stopped for one week. It now

appears however that this method, in some patients, permits a significant

level of deterioration during the untreated period.

Current advice therefore is to take the treatment for two weeks, after which

it may be appropriate to take a break of three or four days.

This pattern of intermittent use will allow the body, during the

non-treatment period, to readjust back to a normal state of activity so that

when the drug is reintroduced once again it will have a renewed and enhanced

effect, thus maintaining the therapeutic benefits.

Thus, after the introductory first month of treatment at 3mg, if there are

no excessive problems with this dose, take two weeks of the 4.5mg capsules

to establish the level of response at this dose. It would then be

appropriate to stop treatment for three days, after which therapy is

continued with two weeks on and three days off in a regular repeating

pattern of use.

It is anticipated that this method of use will reduce the risk of MS relapse

following temporary or prolonged withdrawal of the drug for whatever

reason. "

----- Original Message -----

From: " LarryGC " <larrygc@...>

" LDN group " <low dose naltrexone >; " Spotlight_Med "

<Spotlight_med >

Sent: Wednesday, May 14, 2003 5:45 PM

Subject: [low dose naltrexone] " Missing " doses

> I was reading old old newsgroup messages and I found someone saying he

wasn't

> taking LDN every day. Something like 14 days on, and 3? days off? or 21

days

> on? I'm not sure of the skipped days.

>

> Does anyone take only 6 a week, and skip one night a week? Or anything

other

> than 1 a day?

>

> Would there be any benefit, or reason, behind not taking it every day?

>

> The other question would be, if anyone missed the 9pm-3am window and

therefore

> missed a day unintentionally, have you noticed any affects that very next

day?

>

>

>

>

>

>

>

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THANKS!

It kinda makes sense. I'm taking the 3mg... I have a 6 month refill of

them,... how would I get 4.5's to try, without having my prescription changed?

There are people that are taking it once a day for a long period of time

without any breaks, right? Has anyone noticed their body 'accomodating'?

----- Original Message -----

From: " Sue Goose " <suegoose@...>

" LDN group " <low dose naltrexone >; " Spotlight_Med "

<Spotlight_med >; " LarryGC " <larrygc@...>

Sent: Wednesday, May 14, 2003 16:30

Subject: Re: [low dose naltrexone] " Missing " doses

> The doctor prescribing my LDN has suggested taking it for 14 days and

> missing 3. Below is a quote from his notes:

>

> " Intermittent Therapy: When a drug is used for a prolonged period of

> treatment, even at the very low dose as used in this circumstance, it

> remains possible that the body will slowly adjust to the continuous presence

> of the drug, when the response to that drug will eventually diminish. This

> process is referred to as accommodation, when the body eventually develops a

> tolerance to the drug.

>

> In addition, as a result of this process of accommodation, continuous use of

> a drug will also create a situation of dependency. In this circumstance,

> what was previously considered to be a normal state of physiological

> activity (in this case, the level of brain endorphins produced) will become

> dependent upon the continuing presence of the drug.

>

> To prevent this situation developing, and contrary to the advice suggested

> by Dr Bihari, it is considered advisable to use a form of intermittent

> therapy. Initially, the suggested routine was to take the naltrexone each

> day for three weeks, after which treatment was stopped for one week. It now

> appears however that this method, in some patients, permits a significant

> level of deterioration during the untreated period.

>

> Current advice therefore is to take the treatment for two weeks, after which

> it may be appropriate to take a break of three or four days.

>

> This pattern of intermittent use will allow the body, during the

> non-treatment period, to readjust back to a normal state of activity so that

> when the drug is reintroduced once again it will have a renewed and enhanced

> effect, thus maintaining the therapeutic benefits.

>

> Thus, after the introductory first month of treatment at 3mg, if there are

> no excessive problems with this dose, take two weeks of the 4.5mg capsules

> to establish the level of response at this dose. It would then be

> appropriate to stop treatment for three days, after which therapy is

> continued with two weeks on and three days off in a regular repeating

> pattern of use.

>

> It is anticipated that this method of use will reduce the risk of MS relapse

> following temporary or prolonged withdrawal of the drug for whatever

> reason. "

>

>

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  • 3 years later...

yea, same here. Never missed two in a row.. Even my homemade went with me on out of town trips, it had it's own special little cooler. :0))

[low dose naltrexone] Re: Okay! Since I am Dense~How do I find Message 242.......> > > LarryGC,> What is the schedule that YOU have used (for taking LDN)in these past three years? Do you skip doses routinely?>

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