study in Canada

[Guest guest]

I had tried minocin (minocycline) for about 6months after seeing a friend of mine with scleroderma get her life back after trying it as a last resort.( I have stopped since starting LDN.) I figured it may work for MS being an autoimmune disease. I read that in Canada there is a trial for minocycline for MS. I cannot access any results or info about it. The only positive result I have seen is that I was supposed to go for periodental work and now my dentist has told me my gums are perfect and could not believe how that change happened. It is an antibiotic used for acne mostly.

There is an organization The Road Back that follows the minocycline protocol for Rheumatoid Arthritis and Scleroderma. My question to all my LDN resarchers is....Does anyone know anything more about Minocycline for MS.?? ( incase you are bored)

Kiki

[Guest guest]

Thanks , I have not had any relapses on it , so I guess I will resume. If you do take it , you must take alot of Vit C and the 100mg in the morn made me dizzy so be careful. I had to hold the walls to walk so I only took 100mg before bed. Also the brand name Minocin is recommed http://www.healthwell.com/healthnotes/healthnotes.cfm?ContentID=1157007nded. Kiki

[Guest guest]

Here's info on the minocycline study:

http://www.mult-sclerosis.org/news/May2003/EmergingTherapiesforMS.html

Minocycline. This oral drug belongs to the tetracycline family of antibiotics. It has been available for over 30 years and, in the United Kingdom alone, more than 6.5 million people have been treated with minocycline for an average of 9 months, mostly for acne. Recent studies have identified that minocycline has many immune-modulating properties. It also crosses the blood-brain-barrier (BBB) efficiently, which many other drugs cannot do. In laboratory studies, mincocyline suppressed T cell responses as well as the activity of CNS microglia cells that are thought to be important contributors to injury in MS. When used to treat EAE, minocycline was found to be quite effective at delaying and limiting disease activity. Minocycline is widely available as a generic medication and is relatively inexpensive. These features make minocycline an excellent candidate to be evaluated for treatment of MS. At the AAN meeting, scientists reported on the first clinical trial of minocycline in MS (3). Ten patients with active relapsing-remitting MS were enrolled in the study. After a three-month observation period, treatment was initiated with minocycline by mouth twice daily. Whereas prior to treatment, 80% of patients had active MS by MRI scanning, none of the treated patients have shown subsequent MRI evidence of activity, as much as nine months later. There have been no safety concerns. It is likely that larger MS trials of minocycline will be initiated over the next year.

I will probably ask my doctor to prescribe it--200 mg daily; 100 mg twice a day is what they studied.

----- Original Message -----

From: noclue915@...

low dose naltrexone

Sent: Monday, September 22, 2003 11:58 AM

Subject: [low dose naltrexone] study in Canada

I had tried minocin (minocycline) for about 6months after seeing a friend of mine with scleroderma get her life back after trying it as a last resort.( I have stopped since starting LDN.) I figured it may work for MS being an autoimmune disease. I read that in Canada there is a trial for minocycline for MS. I cannot access any results or info about it. The only positive result I have seen is that I was supposed to go for periodental work and now my dentist has told me my gums are perfect and could not believe how that change happened. It is an antibiotic used for acne mostly.

There is an organization The Road Back that follows the minocycline protocol for Rheumatoid Arthritis and Scleroderma. My question to all my LDN resarchers is....Does anyone know anything more about Minocycline for MS.?? ( incase you are bored)

Kiki