LDN as it used to be, Back to basic!

[Guest guest]

The " ideal " LDN dosage is obviously dependent individual by

individual but it has nothing to do with body size or sex.

If the benefice threshold of LDN was so thinner as someone is saying,

than, LDN just wouldn't work!!

In fact, this same threshold changes not only by the person but also,

hour-by-hour, day-by-day, and season-by-season within the same

individual.

This effectiveness threshold of LDN to partially block opioid

receptors is quite wide…it ranges between 1mg and 10mg:

From Bihari's LDN patent:

" Naltrexone and naloxone are both essentially pure opiate antagonists

which also exert strong preferential blocking action against Mu over

Delta sites, the Mu blocking action being generally rated at about

ten times the Delta blocking action. "

And again:

" The useful dosage range, at which Mu receptor sites are

substantially blocked while the Delta sites are substantially

unblocked, for naltrexone is about 1-10 mg/day daily. The limits of

this range are not critical but below about 1 mg the therapeutic

effect is quite small, while at levels several times above 10 mg, at

which these drugs have been generally administered in the past for

other purposes, especially narcotic addiction, the effects of the

preferential blocking action against Mu over Delta receptor sites

disappears, since the amount of the drug is large enough to cause at

least substantial blocking of Delta sites while the Mu sites remain

fully blocked. A preferred range for naltrexone is about 1.5-3.0

rag/day daily " .

The suggested preferred range above of about 1.5 to 3 mg/day has been

more recently revised by Bihari to 1.5mg to 4.5 mg.

Many of Bihari's patients end up taking 4.5mg (from supplying

Pharmacy's information).