QUESTION?

[Guest guest]

> Your reccommendations to take LDN at the same time every day and

> also, that, more is not always better in doseage, are very sound

> therories. My question: What do you think is the best time to take

> your ldn....is this an individual thing or is there a *best* time

to

> take it. You have read all this stuff....so what time of day or

> night have you decided to talk your ldn, and is it working for you

> so far?

More may not be better. Less may be better (more active in your

immune system).

I have as yet no prescription. Almost off Avonex now, and will see

neurologist next Monday.

I will discuss it with her, but I think before bed seems to be working

for some here :-)

I think it is at the nadir of the natural endorphin cycle, and that

the real effect may not be blocking inhibitory receptors, but blocking

excitatory receptors, as it is with PTI-801 and 901. This implies

that the timing may be related more to the negative effects of our

low but not zero endorphin production at its low point. Anyway

Dr. Bilhari has done real experiments on real patients with lots of

different problems, and if he says bedtime, I'm likely to believe him.

Why that works I'm not so sure, but some things I do just accept

without knowing why. Like the furnace repair bill.

> You have already helped me to do some thinking and I have decided

> that I felt better on 3mg than on 4.5mg. The 4.5 may be doing too

> much blocking and not enough boosting?

It can not boost (unless it's the rebound effect from the blockade).

Its own direct action at high dose is an opiate inhibitory receptor

blockade. At ultra low doses, it, and many other antagonists and

agonists (morphine, oxycontin, naloxone, etc.), cause an opiate

excitatory receptor blockade. That is why when combined with

high dose morphine you get no addiction. I don't know what it does

in Dr. Bilhari's range of concentrations. But I suspect

the changeover is somewhere in there.

As I said I intend to start at 4.5 and lower the dose carefully

to and below 1.5mg, unless I have an attack.

-Sullivan

PS Maybe LDN combined with endorphin is a good combination, like

ULDN (ultra) and oxycontin. In which case the peak time is better. Think

I'll try it, after I have tried the other. Peak is in the morning

(6am-10am).