Fw: faroe islands..QUESTION?

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----- Original Message ----- From: jchrissullivan

Sally

Sent: Tuesday, September 09, 2003 5:29 PM

Subject: Re: faroe islands..QUESTION?

> Hi First of all I'd like to know if you are M/F (I have a > son and a girlfriend Chris)...lolWe were just talking (my wife and I) about the ambiguity offirst names on the Internet... I am as male as circumstancespermit.> > Your reccommendations to take LDN at the same time every day and > also, that, more is not always better in doseage, are very sound > therories. My question: What do you think is the best time to take > your ldn....is this an individual thing or is there a *best* time to > take it. You have read all this stuff....so what time of day or > night have you decided to talk your ldn, and is it working for you > so far?I have as yet no prescription. Almost off Avonex now, and will seeneurologist next Monday.I will discuss it with her, but I think before bed seems to be workingfor some here :-)I think it is at the nadir of the natural endorphin cycle, and thatthe real effect may not be blocking inhibitory receptors, but blockingexcitatory receptors, as it is with PTI-801 and 901. This impliesthat the timing may be related more to the negative effects of ourlow but not zero endorphin production at its low point. AnywayDr. Bilhari has done real experiments on real patients with lots ofdifferent problems, and if he says bedtime, I'm likely to believe him.Why that works I'm not so sure, but some things I do just acceptwithout knowing why. Like the furnace repair bill.> You have already helped me to do some thinking and I have decided > that I felt better on 3mg than on 4.5mg. The 4.5 may be doing too > much blocking and not enough boosting?It can not boost (unless it's the rebound effect from the blockade).Its own direct action at high dose is an opiate inhibitory receptorblockade. At ultra low doses, it, and many other antagonists andagonists (morphine, oxycontin, naloxone, etc.), cause an opiate excitatory receptor blockade. That is why when combined with high dose morphine you get no addiction. I don't know what it does in Dr. Bilhari's range of concentrations. But I suspectthe changeover is somewhere in there.As I said I intend to start at 4.5 and lower the dose carefullyto and below 1.5mg, unless I have an attack.-Sullivan

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