Re: high versus low dose

[Guest guest]

Hi Chris.....I love your posts....especially this one.

I have a question...Does the below remark mean to imply, that if you

take your LDN at 9:00pm and your endorphin prod. started at 3:00am,

then it doesn't matter what amt of ldn you take, it won't work,

because it is out of your system???

I hope I understood you wrong, because there are a lot of people

taking it at 9pm???

Thanks, Sally

<chris_sullivan@s...> wrote:

> OK, I saw on myremedy.com that lots of folks are on 4.5 mg.

the stuff only stays

> in your system about 6 hours. So if you took it by 9pm and your

> endorphin production started at 3am it would not matter if you were

> over the threshold, since a) you would be asleep and it would

> be out of your system by then.

[Guest guest]

No, that is not what I was trying (unsuccessfully) to say.

I was trying to say that taking it at 9pm avoids the problem

of being above threshold, if you happen to be. But if you are,

and you normally would not wake up in pain because of the

pain killing effect of endorphin rescuing you, it may wake you

up with some pain, if you take it later. So take it later if you

want but don't take too high a dose or it will be in its other

mode of blockading pain killer.

This is all speculation, of course. If you take it at 9pm, and you

are below threshold with your dose, then you should not suffer from

blockading of your " good " receptors. The blockade should only be on

your " bad " receptors.

There are two theories of what happens next. After 3am when you

start producing endorphins, Dr. Bilhari and the ldninfo page both

say your body responds to the blockade by producing more endorphin

than it otherwise would have. That is probably true but

this " rebound " may not be the reason. It may be that the blockade

just happening at the same time every day entrains your 24-hour

cycle better and your body gets better at it.

The other thing that *may* be happening is there is still enough

LDN in your system (a very small amount is enough), that the

blockade of the " bad " receptors continues after 3am, possibly fixing

whatever is causing you to be slow to kill off those rogue T cells.

That may have to do with action potential duration (APD) being

prolonged by the " bad " receptors, which are now being blockaded. So

APD has a chance to be shortened by endorphin and they react fast

enough to kill the T cells before they have a chance to signal the

macrophages to wipe out some myelin. Maybe.

Another possibility is that it doesn't matter that you have not

produced any endorphin yet, since the effects of the " bad " receptor

blockade may be enough to fight your MS (or cancer). And the

increase in endorphin might be just a nice bonus.

But what I am hoping is that by taking a low enough dose *during*

the endorphin peak, I will get both entraining of my 24-hour

endocrine cycle *and* blockading of the " bad " receptors when the

" good " receptors are most active. I am guessing that is what happens

in Larry's case. It may not work. But I'm hoping that I'll feel a

*lot* better in the morning. I may need to split

the dose to cover the afternoon too. Or something altogether

different may happen. I will certainly try the conventional protocol

first.

Now that I've sufficiently muddied the waters, it's time for bed.

-Sullivan

" Not necessarily. I could be arguing in my spare time. " M. Python

> > OK, I saw on myremedy.com that lots of folks are on 4.5 mg.

> the stuff only stays

> > in your system about 6 hours. So if you took it by 9pm and your

> > endorphin production started at 3am it would not matter if you

were

> > over the threshold, since a) you would be asleep and it would

> > be out of your system by then.