high versus low dose

[Guest guest]

OK, I saw on myremedy.com that lots of folks are on 4.5 mg.

There is somehow a natural and hard to change tendency to

believe more is better.

Dr. Bilhari's own patent refers to the drug naltrexone working

on one kind of receptor at high dose and another altogether different

one on low dose. That means you *must* be using a dose that is

low enough so that the drug is blocking those other receptors and

*not* blocking the opioid/endorphin receptors. That is why you

take it *before* your endorphin production starts. According to

Dr. Bilhari (you won't find this on ldninfo.org since it is in a

350 page paper written by the US government) the stuff only stays

in your system about 6 hours. So if you took it by 9pm and your

endorphin production started at 3am it would not matter if you were

over the threshold, since a) you would be asleep and it would

be out of your system by then.

The effect at high dose (over about 4.5 mg on average) is to

block opioid receptors so that if you have pain, it may get

worse, if you have narcotic withdrawal, it may get worse, and if

you take painkillers (or your body cranks out some endorphins)

THEY DON'T WORK.

So if you have pain or stiffness in the middle of the night, you

may be taking TOO MUCH LDN. Reducing the dose may help. Some people

seem to be advocating just grinning and bearing it since it may go

away eventually. But there is another problem. If you are over that

magic threshold in your dose, it can't be blocking those " bad " receptors

that is blocks when the dose is low enough. It has a dual action and

the action at the 4.5-50mg dose is the one we don't want. So if you

have pain and think it's the LDN, take 1mg less. This may work better

than changing the filler or trying to tough it out.

I am going to test all this on myself real soon, but that is my

advice. I do not think 4.5 mg is better than 3, for those who have

the leg problems. Don't start low and increase to 4.5mg. Start at

4.5 mg and if you have pain, reduce the dose! Your opioid receptors

(of both kinds) will thank you for it.

-Sullivan