Guest guest Posted October 5, 2003 Report Share Posted October 5, 2003 Thanks Jane....Your post is very encouraging to me.....I too use a wheeled seat walker.....and a scooter, for longer distances. When I started on LDN I was ready to order a wheel chair.....LDN has kept me on my feet....not better but not worse, and I thank God for that blessing. I too, believe LDN has stopped the progression. Hugs, Sally Jane Young <iamyoung51@y...> wrote: > Hi everyone! > I started at 3mg at 8PM and am finding I am waking at > 2:30 - falling back to sleep at 3:30AM. This seems to > be 'the norm' so I am not worried...just do nap in the > afternoon. By 4PM I am definitely finding it > difficult to walk and have friends drive for night > activities. > > I had been up to 4mg but found out the filler was not > avicel and started all over. I do find that my general > fatigue is less and that in the morning my walking is > better. Still need rolling walker with seat but feel > more confident in the morning. > > Hang in there and know we are all praying you stay on > it long enough to see results. I do believe the MS > progression I was experiencing has halted...praise > God! > > Remember, we are not alone!! Jane Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 6, 2003 Report Share Posted October 6, 2003 > >I agree that 2mg would be an appropriate dose to start with. 2mg will >be enough to stop MS progression but I believe that the therapic >effect of a larger dose could be even better (this is what I have >told by Dr. Lawrence and what you will hear from most of the MSers >here). > I was on 4.5mg but it stopped working. Had a word with Bob Lawrence and he said he had the same problem after a long period of use. His solution was the drop to a lower dose after a short break. That's what I did and it worked. I'm now on 3mg for ten days followed by a two day break. Taking 3mg every day does not work for me. It helps less as the days go on but if I take a break it starts working again. Steve Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 6, 2003 Report Share Posted October 6, 2003 Sounds good Steve.....and that is what my Pharmacist says also. Thanks, Sally steve@t... wrote: > I was on 4.5mg but it stopped working. Had a word with Bob Lawrence > and he said he had the same problem after a long period of use. His > solution was the drop to a lower dose after a short break. That's what > I did and it worked. I'm now on 3mg for ten days followed by a two day > break. Taking 3mg every day does not work for me. It helps less as the > days go on but if I take a break it starts working again. > > Steve Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 6, 2003 Report Share Posted October 6, 2003 Hi Steve, Thank you for sharing this precious info. I cannot find much about LDN loss of effectiveness from the official LDN website. I can read about " resistance " towards Naltrexone…that is probably different since this term refers to allergies towards LDN.. Bihari disagrees with Lawrence about the need of intermittent therapy. In most of the documentations from Bihary, you will always find written that has never been any evidence of resistance to the Naltrexone. For example: http://www.low dose naltrexone.org/ldn_hiv_1996.htm " Some patients in this study have been on Naltrexone for as much as 7 to 8 years, with no disease progression CD4 drop and no evidence of resistance to the beneficial effects of the drug " . However, from somewhere else (I cannot find it now…) I remember I read Bihari admitted a small number of people developing signs of resistance to LDN among his patients (a very small percentage, to be honest). It would be interesting to hear from any Bihari patient that had your same problem of loss of efficacy because of the continuous use of LDN, how Bihari understood it and responded.... Quote Link to comment Share on other sites More sharing options...
Guest guest Posted October 6, 2003 Report Share Posted October 6, 2003 Called in medical parlance tachyphylaxis. --- In low dose naltrexone , " maxbtm " <maxbtm@y...> wrote: > Hi Steve, > > Thank you for sharing this precious info. > I cannot find much about LDN loss of effectiveness from the official > LDN website. > I can read about " resistance " towards Naltrexone…that is probably > different since this term refers to allergies towards LDN.. > > Bihari disagrees with Lawrence about the need of intermittent > therapy. In most of the documentations from Bihary, you will always > find written that has never been any evidence of resistance to the > Naltrexone. > For example: http://www.low dose naltrexone.org/ldn_hiv_1996.htm > " Some patients in this study have been on Naltrexone for as much as 7 > to 8 years, with no disease progression CD4 drop and no evidence of > resistance to the beneficial effects of the drug " . > > However, from somewhere else (I cannot find it now…) I remember I > read Bihari admitted a small number of people developing signs of > resistance to LDN among his patients (a very small percentage, to be > honest). > > It would be interesting to hear from any Bihari patient that had your > same problem of loss of efficacy because of the continuous use of > LDN, how Bihari understood it and responded.... Quote Link to comment Share on other sites More sharing options...
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