Re: Endorphins' role in MS progression; Italian own check.

[Guest guest]

Max,

Thanks for the information - it is comforting to know that someone in the field of research is interested in LDN. Maybe if the word gets around we will all eventually benefit.

Sue

----- Original Message -----

From: maxbtm

low dose naltrexone

Sent: Tuesday, September 02, 2003 5:56 PM

Subject: [low dose naltrexone] Endorphins’ role in MS progression; Italian own check.

From: http://www2.xagena.it/xagena/9019_eneurologiait.htmThis recent article confirms that a MS suffers have low Beta-endorphins levels. It is dated August 2003. This result comes from the San Raffaele Italian Hospital. They also know about LDN because my sister told them about it last July when she wanted to take Naltrexone. (This is also the same Italian research centre leading the research for the staminal cells). In Brief:Researchers of San Raffaele, Milan, verified the existence of a possible link between beta-endorphins levels (an endogen opium like substance) and the heterogeneous clinic progress of the MS.They have been measured concentrations of beta-endorphins on mono-nucleic cells of peripheral blood (PBMC) on 50 patients on different phases of MS development.The highest concentrations of beta-endorphins have been found in patients with RR MS, while the lowest levels among these patients with progressive forms of MS.These results confirm that beta-endorphins can have a role in reducing the inflammatory process at the basis of MS. Massimo

[Guest guest]

>Message:

>Date: Tue, 02 Sep 2003 19:31:54 -0000

>From: " " <davizona@...>

>Subject: Re: Endorphins' role in MS progression; Italian >own check.

>

>Makes sense, someone on the Goodshape site is doing >9mg nightly, and

>sometimes 9mg more during the day. He doesnt believe >the Bihari

>theory, thinks the LDN does something..(else or more)

>He says the 9-18mg helps him a lot.

Since your friend is experimenting on himself he might try

nanodoses or picodoses. Levels to try might be 0.9mg,

90 ug (10x lower), 90 ng (100x lower). I am quite

serious, since nano and picomolar concentrations of

Naltrexone have been found to be more active (and in a

different way) than the FDA 50mg dose. Even as low as

600 molecules have a marked effect. Some well known

recreational drugs have to be measured in micrograms

using a drop of liquid on blotter paper because of the

large effect that micrograms have on our brains.

There is a threshold below which the action of Naltrexone

reverses, and the lowdose web page says it should be

between 1.5 and 4.5 mg. But there is work going on that

involves very low doses of Naltrexone for analgesia, and

these researchers are interested more in its effect on the

usefulness and side effects of opiates. There is even a drug

trial going on now that involves an opiate and ultra

low dose Naltrexone.

It may not be so much that it enhances endorphin

production (though it seems as well to do that) but that

it enhances endorphin effectiveness (as it does with

opiates). Dose levels and the threshold where it changes

from antagonist to agonist may be critical in this usage.

http://www.aecom.yu.edu/home/news/narcotics.htm

http://www.pharmcast.com/Patents/Yr2002/May2002/052802/6395705_Bowel052802.htm

http://www.pharmcast.com/Patents/Yr2002/May2002/052802/6395705_Bowel052802.htm

see also Crain and Shen in

http://www.drugabuse.gov/pdf/monographs/147.pdf

''In addition, 10 fM beta-endorphin elicits

marked naloxone-reversible enhancement of the cytotoxic " natural killer "

cell activity of human blood cells (see figure 1; dose-response curve in

Mathews et al. 1983).''

fM is femto-Molar! this is 10^-15 of a Mole, I think...

see also R. Suzanne Zukin, Ann Tempel, and Eliot L. Gardner in

http://www.drugabuse.gov/pdf/monographs/54.pdf

There are also articles on the influence of endorphins on

the immune system...

Be careful. If you are squeamish you may not want to

read about the things they do to rats and mice.

-Sullivan