land Update - Splitting the Doses

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Hello again! I haven't posted in a while, but I haven't missed a day on this board. I wanted to weigh in today on two burning questions which come up time and again in this forum. Those questions would be (a) is it possible, in terms of dose, that less might be more? and ( contrary to Dr. Bihari's recommendation, might there be any upside to splitting one's daily dosage? When my wife Debbie finally got off Avonex and Rebif after four years on that road, she started to get her life back a little. When we got her introduced to LDN, more improvement ensued. I've talked with her at length about the threads on this board which discuss why is is unlikely that LDN will ever have any clinical studies done for its impact on MS because of the $$$$$$$ factor and the antagonism it would get from big pharma and the traditional medical mindset. I, personally, love the idea that we here - all of us - are running our own clinical study, albeit informal and anecdotal, day in and day out . . . . and that our story - our results - mean something - if only to us. Truth is, there's power in that - there's an awful lot of power in that. We have changed minds already - - like that of our neurologist, who wrote the scripts for both of us based on information we brought him from this board. The bottom line is this. LDN has very little downside, comparatively speaking. It's not like that multitude of drugs we see advertised every day on TV which run through 90 seconds of side effects - everything from possible stroke to oily discharge (my favorite) - where you're left with the idea that the disease couldn't possibly be as bad as the side effects of the drugs they're pushing to treat it. Armed with that logic, three days ago we got large prescriptions filled for 1.75 and 1.5 mg. of LDN. Our filler, incidentally, is gelatin. Ron, our compounder, feels gelatin to be the best for mixing LDN. Deb had been taking 3 mg. each evening before bed and had been getting some 2 a.m. to 6 a.m. "miracles" from time to time, but by morning and throughout the day things were pretty much the same as they were before she started LDN. She did that for about 2 months. Three nights ago Deb took 1.5 mg. before bed and another 1.5 mg. mid-morning. And the difference is hard to describe. Aside from all the motor improvements, etc., some of which are sustained throughout the day, I am having a hard time believing the attitudinal change. I actually heard her say she felt good yesterday morning for the first time in Heaven knows how long. The girl can smile, and that smile was as beautiful yesterday as it was the first day I met her. Three days does not a success story make. I know that. But we're 3 for 3 heading into tonight. And we're branching off into a relatively fertile area of our collective LDN research in this large, collective, clinical study of ours. Semi-pioneers of a sort. Just wanted to report in to the troops that things are looking very good on this flank. Certainly will keep you posted as we move further down this road. -Al