dose again, and a bit of circadianism...

[Guest guest]

OK: I'm not an MD. So don't take my advice, but listen. A *lot* of

people are working on ultra low dose naltrexone as an adjunct to

morphine to stop withdrawal being a problem. Lots of pushers won't

like that.

I keep seeing the same thing over and over - " I'm starting at the low-

low dose and working my way up to the high-low dose. " It is counter

intuitive but the low low dose maybe works *better*! I also see

a lot of " maybe I'm not taking enough " ! Maybe you're not taking

too *little*. Doesn't it make sense that if a lower dose has an

entirely different effect from a much higher dose, and it's the one

we're looking for, maybe we should try looking at a *lower* dose if

we're still having problems?

*Not*, emphatically *not* zero. But lower. Talk to Dr. Bilhari.

Also, I said (I hope) to make sure it is *not* slow release. The

important thing is the *pulse* of blocking your immune system is

reacting to. A pulse starts and stops quickly, which may relate to

the dosage effect also.

Now for other matters. It has occurred to me that we may be looking

at a second-order effect of sun timing. Maybe the difference between

lattitudes is the greater *variation* in the length of the day. Maybe

some people (and their parents, the females of whom pass it on) are

more susceptible to *variations* in the length of the day, because

their circadian release of endorphins does not train well (the

training starts before birth). Maybe what we are doing by taking LDN

at the same time every day, causing a pulse of blocking, is to entrain

the circadian rhythm, which has been erratic or missing. Maybe part

of the reason for apparently increased incidence and for third world

immunity is that somebody invented electric lighting, making it

possible to ignore our circadian imperatives. And don't forget

daylight saving time. Anybody have more attacks in the fall? Spring?

Summer? Winter? Why? Did your mother stay up to odd hours before

you were born? Is there a difference between firstborns and others

in the incidence of MS? So many questions...

I would really like to know what anyone thinks...

-Sullivan

[Guest guest]

I'm a 57 year old female who grew up in Texas and loved being in the sun. I've had MS for 13 years. My mother went to bed early, but I've always been a night owl. I agree that a lower dose of ldn may be better, as it's my experience that drugs, etc., react differently on all MS patients. In addition, I find that my symptoms are worse in cold humidity, which is good since I now live on the gulf coast in Northwest Florida. The only drawback to living here is there are no MS specialists here like there were in Dallas; and, of course, being an obnoxious Texan--I miss Texas. I do enjoy reading everyone's e-mails and am trying to make an informed decision about taking ldn. Have a great day! Sally A.

[Guest guest]

Sally A:

Well! You might want to look at it this way. There's no information, etc. that LDN has ever hurt anyone other than discomfort of insomnia, leg stiffness/cramps, etc. that can be relieved by reducing the dosage.

Also, LDN's cost doesn't put you in the poor house. Therefore, you have very little to lose and a whole lot to gain.

Noland

----- Original Message -----

From: BoggyFla11@...

low dose naltrexone

Sent: Friday, September 12, 2003 12:31 AM

Subject: Re: [low dose naltrexone] dose again, and a bit of circadianism...

I'm a 57 year old female who grew up in Texas and loved being in the sun. I've had MS for 13 years. My mother went to bed early, but I've always been a night owl. I agree that a lower dose of ldn may be better, as it's my experience that drugs, etc., react differently on all MS patients. In addition, I find that my symptoms are worse in cold humidity, which is good since I now live on the gulf coast in Northwest Florida. The only drawback to living here is there are no MS specialists here like there were in Dallas; and, of course, being an obnoxious Texan--I miss Texas. I do enjoy reading everyone's e-mails and am trying to make an informed decision about taking ldn. Have a great day! Sally A.