timing again

[Guest guest]

I excerpt a letter I just wrote to LarryGC:

Neither your circadian rhythm nor your daily endorphin production is

based on what time you go to bed (au contraire). Both are cued by

light. In the neonatal case, it is the mother's plasma concentration

rhythm that the infant has learned.

Going to sleep is cued by the levels of endorphin (low) and melatonin

(high) among other circadian hormone cycles.

>He said take it 9pm - 3am, and I take it between midnight and 3AM,

>usually closer to 2

....the beta-endorphin peak is after (or at the same time as)

circadian sunrise. Do not take my word for it!

> Bihari says it's the predawn hours that LDN is needed prior, so

> that's why the 3AM cutoff... I figure 4AM DST, 3AM during the

> winter months.

That means he thinks it should be synchronized to coincide with your

endorphin low point, and taken before it starts to increase again,

which happens around 3-4AM if you have not gone nocturnal (changed

your internal schedule) so that it is out of your system (he believes

this takes 4-6 hours) by the endorphin peak when you get up. That is

because it started life as an inhibitory receptor antagonist, and we

don't want to antagonize endorphin, we want to boost it. Ultra low

doses blockade excitatory receptors so maybe we should be taking it

at the peak hour (circadian morning). That may be what you are doing

that's righter than everybody else. That has implications

I would want to share with so-called " terminal " disease patients.

....

" Well it'll be in about five minutes' time, according to the very

ancient pyramidic scrolls and me Ingersoll watch...That is if the

word of God is anything to go by...... "

" ...Perhaps we'd better compose ourselves... "

" Right, prepare for the end of the world. Five, four, three, two,

one.

NOW IS THE END. PERISH THE WORLD. "

.... " It was GMT, wasn't it? "

" Well lads, same time tomorrow. We'll

get a winner one day. "

- Beyond the Fringe

-Sullivan