Re: Check out BiotechTracker - BioMS’s Multiple Sclerosis Drug Moves Forward

[Guest guest]

(HLA)-DR2 is an allele which is commonly linked to MS. When presented

by HLA-DR molecules with an antigen which mimicks a CNS component

(myelin basic protein), T-cells are activated. It may be the wrong

activation of these cells or some other mechanism which normally

suppresses the resulting inflammation which is the cause of MS.

If suppression of T-cells (caused by apoptosis induced by some

normally present factor, absent in MS) is the real problem, then the

immune system is not working too well, it is not working well enough.

The blockade of excitatory opioid receptors by LDN may allow this

component to operate, in which case the extra endogenous endorphin is

just a useful side-effect.

Or production of more normal levels of inhibitory endorphin may be

what is missing. In both cases what is needed is an increase in

immune system function, not a decrease. It may be (no one can say)

that my progression from RR to CP has been caused or at least speeded

up, by the use of interferons. Certainly the flu-like symptoms which

are an indication that interferon antibodies are absent, are a form

of inflammation, and real flu inflammation is an exacerbation trigger.

That has always been my suspicion. It is unnatural to conclude that

by having the flu all the time inflammation and its results will be

decreased. Maybe the placebo controls had a higher level of

low grade cutaneous infection due to the fact of using needles and

real interferons lowered that because their lower pH (more acidity)

killed more germs.

That's why I want to try LDN, and someone (else) to study it.

-Sullivan

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here: BiotechTracker - BioMS’s Multiple Sclerosis Drug Moves

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[Guest guest]

Sounds like another abcr to me.....time will tell. ~Sally

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HREF= " http://www.bioportfolio.com/news/biotracker_130.htm " >Click

here: BiotechTracker - BioMS’s Multiple Sclerosis Drug Moves

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[Guest guest]

Thank you for all your info....and I hope you get your LDN

soon.

Sally

> (HLA)-DR2 is an allele which is commonly linked to MS. When

presented