Guest guest Posted November 6, 2003 Report Share Posted November 6, 2003 On Thu, 06 Nov 2003 12:40:57 -0000, you wrote: > " Among MS forms, the highest ß endorphin concentrations were found in >PBMC from patients with relapsing remitting MS and the lowest in >patients with the progressive forms. " > >So can it be concluded from this that LDN will be less effective with >the progressive form? I have PPMS and it seems as if there's been >slight progression--more numbness in my feet, less balance, more >wobbliness. I've been on LDN 11 weeks and upped the dose to 4.5 from >3.0 last week. > >Martha > I have had PPMS for a long time and I have been taking LDN for about a year. It has not stopped progression. My walking improved when I first started LDN but it became less effective after a few weeks. This short term boost can be repeated by taking a two day break. Steve Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 6, 2003 Report Share Posted November 6, 2003 Hi Steve, thanks for the advice on 2 day break. Can I ask you where you get your LDN from and why didn't you start on 4.5? Do you think the larger dose may stop progression? You say you progressed in the last 11 weeks, was you progressing that quickly without LDN ? Hope the 4.5 works better for you! Thanks for the info Kiki Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 6, 2003 Report Share Posted November 6, 2003 a) can the results stand up if they measured the endorphin at different times of day? interferon sems to increase endorphin. c) if they are correct, LDN may be less effective in SPMS and PPMS. -Sullivan > " Among MS forms, the highest ß endorphin concentrations were found in > PBMC from patients with relapsing remitting MS and the lowest in > patients with the progressive forms. " > > So can it be concluded from this that LDN will be less effective with > the progressive form? I have PPMS and it seems as if there's been > slight progression--more numbness in my feet, less balance, more > wobbliness. I've been on LDN 11 weeks and upped the dose to 4.5 from > 3.0 last week. > > Martha Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 7, 2003 Report Share Posted November 7, 2003 On Thu, 6 Nov 2003 14:54:30 EST, you wrote: >Hi Steve, thanks for the advice on 2 day break. Can I ask you where you get >your LDN from and why didn't you start on 4.5? Do you think the larger dose may >stop progression? You say you progressed in the last 11 weeks, was you >progressing that quickly without LDN ? >Hope the 4.5 works better for you! Thanks for the info Kiki My LDN comes from Bob Lawrence and I did start on 4.5 but dropped to 3 later. I did not notice any difference other than the abdominal cramps were more common on the higher dose. I have had PPMS for at least 20 years but it did not progress much until 3 years ago. I started LDN about a year ago. My MS has been going down in steps for a few months. I'm still stumbling about the house leaning on walls and furniture but I can't walk far without something to prop me up. I don't think LDN has slowed the progress but it always improves my steps after the two day break. Steve Quote Link to comment Share on other sites More sharing options...
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