Guest guest Posted November 5, 2003 Report Share Posted November 5, 2003 This paper may be viewed for $8US. It lets you email a link to " a friend " so here goes.... -Sullivan > This seems to prove the often disputed relationship between MS and > endorphin levels in the blood. Very important statements re > progressive vs. rr MS as well. Note use of MRIs. > > SHORT REPORT > > ß endorphin concentrations in PBMC of patients with different > clinical phenotypes of multiple sclerosis > M Gironi1, R Furlan1, M Rovaris1, G Comi1, M Filippi1, A E Panerai2 > and P Sacerdote2 > 1 Department of Neuroscience, San Raffaele Hospital, Milan, Italy > 2 Department of Pharmacology, University of Milan, Milan, Italy > > > Correspondence to: > Dr M Gironi, San Raffaele, DIMER, Via Olgettina 48, 20132, Milan, > Italy; > mgironi@d... > > > ABSTRACT > The possible link between the opioid peptide ß endorphin and the > heterogeneity of the clinical course of multiple sclerosis (MS) was > investigated. Peripheral blood mononuclear cells (PBMC) > concentrations of ß endorphin were measured in 50 patients in > different phases of MS. Thirty nine patients also underwent post- > contrast magnetic resonance imaging of the brain. Among MS forms, the > highest ß endorphin concentrations were found in PBMC from patients > with relapsing remitting MS and the lowest in patients with the > progressive forms. Average ß endorphin concentrations were lower, > although not significantly, in patients with than in those without > magnetic resonance imaging enhanced lesions. These data suggest that > ß endorphin may have a role in the downregulation of the inflammatory > process. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted November 6, 2003 Report Share Posted November 6, 2003 GOOD REPORT CHRIS. MAKES ME FEEL EVEN BETTER TAKING LDN. NOW I SURE HOPE THAT DR BIHARI IS CORRECT AND THAT LDN IS INDEED RAISING OUR ENDORPHIN LEVEL. SINCE WE ARE THE GENEA PIGS, I GUESS ONLY TIME WILL TELL. THANKS CHRIS. SALLY > This seems to prove the often disputed relationship between MS and > endorphin levels in the blood. Very important statements re > progressive vs. rr MS as well. Note use of MRIs. > > SHORT REPORT > > ß endorphin concentrations in PBMC of patients with different > clinical phenotypes of multiple sclerosis > M Gironi1, R Furlan1, M Rovaris1, G Comi1, M Filippi1, A E Panerai2 > and P Sacerdote2 > 1 Department of Neuroscience, San Raffaele Hospital, Milan, Italy > 2 Department of Pharmacology, University of Milan, Milan, Italy > > > Correspondence to: > Dr M Gironi, San Raffaele, DIMER, Via Olgettina 48, 20132, Milan, > Italy; > mgironi@d... > > > ABSTRACT > The possible link between the opioid peptide ß endorphin and the > heterogeneity of the clinical course of multiple sclerosis (MS) was > investigated. Peripheral blood mononuclear cells (PBMC) > concentrations of ß endorphin were measured in 50 patients in > different phases of MS. Thirty nine patients also underwent post- > contrast magnetic resonance imaging of the brain. Among MS forms, the > highest ß endorphin concentrations were found in PBMC from patients > with relapsing remitting MS and the lowest in patients with the > progressive forms. Average ß endorphin concentrations were lower, > although not significantly, in patients with than in those without > magnetic resonance imaging enhanced lesions. These data suggest that > ß endorphin may have a role in the downregulation of the inflammatory > process. Quote Link to comment Share on other sites More sharing options...
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