Re: Chris Sullivan, Nevermind.....I found it

[Guest guest]

--- In low dose naltrexone , " Bren " <TwisterAlley2@w...> wrote=

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> this research page that you posted at MS4?

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> ß endorphin concentrations in PBMC of patients with different clinical ph=

en=

> otypes of multiple sclerosis

> M Gironi1, R Furlan1, M Rovaris1, G Comi1, M Filippi1, A E Panerai2 and P=

S=

> acerdote2

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> 1 Department of Neuroscience, San Raffaele Hospital, Milan, Italy

> 2 Department of Pharmacology, University of Milan, Milan, Italy

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> Correspondence to:

> Dr M Gironi, San Raffaele, DIMER, Via Olgettina 48, 20132, Milan, Italy; =

> mgironi@d...

>

> ABSTRACT

> The possible link between the opioid peptide ß endorphin and the heteroge=

ne=

> ity of the clinical course of multiple sclerosis (MS) was investigated. P=

eri=

> pheral blood mononuclear cells (PBMC) concentrations of ß endorphin were =

mea=

> sured in 50 patients in different phases of MS. Thirty nine patients also=

un=

> derwent post-contrast magnetic resonance imaging of the brain. Among MS f=

orm=

> s, the highest ß endorphin concentrations were found in PBMC from patient=

s w=

> ith relapsing remitting MS and the lowest in patients with the progressiv=

e f=

> orms. Average ß endorphin concentrations were lower, although not signifi=

can=

> tly, in patients with than in those without magnetic resonance imaging en=

han=

> ced lesions. These data suggest that ß endorphin may have a role in the d=

own=

> regulation of the inflammatory process.

JNNP -- Abstracts: Gironi et al. 74 (4): 495

http://jnnp.bmjjournals.com/cgi/content/abstract/74/4/495