Re: Chris Sullivan can you provide the link to....QUESTION???

[Guest guest]

I take this to mean that the endorphin level is lower in people with

sp or ppms....but this is before LDN, not after LDN.....because it

goes on to say that we would benefit from increased endorphin level.

Am I reading this wrong?....Max, Martha, Bren, Steve,

somebody...lol

Sally

> this research page that you posted at MS4?

>

> ß endorphin concentrations in PBMC of patients with different

clinical phen=

> otypes of multiple sclerosis

> M Gironi1, R Furlan1, M Rovaris1, G Comi1, M Filippi1, A E

Panerai2 and P S=

> acerdote2

>

> 1 Department of Neuroscience, San Raffaele Hospital, Milan, Italy

> 2 Department of Pharmacology, University of Milan, Milan, Italy

>

> Correspondence to:

> Dr M Gironi, San Raffaele, DIMER, Via Olgettina 48, 20132, Milan,

Italy;

> mgironi@d...

>

> ABSTRACT

> The possible link between the opioid peptide ß endorphin and the

heterogene=

> ity of the clinical course of multiple sclerosis (MS) was

investigated. Peri=

> pheral blood mononuclear cells (PBMC) concentrations of ß

endorphin were mea=

> sured in 50 patients in different phases of MS. Thirty nine

patients also un=

> derwent post-contrast magnetic resonance imaging of the brain.

Among MS form=

> s, the highest ß endorphin concentrations were found in PBMC from

patients w=

> ith relapsing remitting MS and the lowest in patients with the

progressive f=

> orms. Average ß endorphin concentrations were lower, although not

significan=

> tly, in patients with than in those without magnetic resonance

imaging enhan=

> ced lesions. These data suggest that ß endorphin may have a role

in the down=

> regulation of the inflammatory process.