re:LDN doses

[Guest guest]

Yes, I know that 25mg is too high for us.

What I wanted to find is what was said a few weeks ago. what does

LDN do for the body at that dose that is different to what it dose at the

low dose. Does anyone remember?

thank you

[Guest guest]

As per excerpts from www.LDNinfo.org site;

" The therapeutic dosage range for LDN is from 1.75mg to 4.5mg every night.

Dosages below this range are likely to have no effect at all, and dosages

above this range are likely to block endorphins for too long a period of

time and interfere with its effectiveness. "

" Naltrexone was licensed in 1984 by the FDA in a 50 mg dose as a treatment

for heroin addiction. It is a pure opiate antagonist (blocking agent) and

its purpose was to block the opioid receptors that heroin acts on in the

brain. When it was licensed, Dr. Bihari, then involved in running programs

for treating addiction, tried it in more than 50 heroin addicts who had

stopped heroin use. None of the patients would stay on the drug because of

side effects experienced at 50 mg such as insomnia, depression, irritability

and loss of feelings of pleasure, all due to the effect of the drug at this

dose in blocking endorphins. "

" Naltrexone, when given to mice and people at high doses, raises endorphin

levels in the body's effort to overcome the naltrexone blockade. This drug

became the focus of Dr. Bihari's research group. When the group discovered

that endorphins are almost all produced in the middle of the night, between

2 AM and 4 AM, the studies focused on small doses (1.5-4.5 mg at bedtime)

with the hope that a brief period of endorphin blockade before 2 AM might

induce an increase in the body's endorphin production. In fact, the drug did

so in this dosage range. It had no effect below 1.5 mg and too much

endorphin blockade at doses over 5 mg. "

" ...endorphins are the hormones centrally involved in supporting and

regulating the immune system.... "

Noland

----- Original Message -----

From: " johannefbzzz " <johannef@...>

<low dose naltrexone >

Sent: Friday, October 31, 2003 1:38 PM

Subject: [low dose naltrexone] re:LDN doses

> Yes, I know that 25mg is too high for us.

>

> What I wanted to find is what was said a few weeks ago. what does

> LDN do for the body at that dose that is different to what it dose at the

> low dose. Does anyone remember?

>

> thank you

>

>

>

>