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I just heard from Dr. Crain, who is working with Pain Therapeutics,

on LDN and ULDN for Irritable Bowel Syndrome and analgesia

respectively.

Basically, they are interested but have not heard of any experiences

with ULDN and MS. He said if I wanted to try it the dose I am taking

is maybe 10 or 100 times higher than they use it in. To be ULDN it

needs to be only a few micrograms.

I had been using about 50 micrograms so to do that right I need to

dilute again.

I have been only on the Dr. Bihari dose for a couple of days till I

can get rid of my eye infection.

He agreed that not enough is known about blockading endorphin

with naltrexone to know whether it can lead to exacerbations. But I

told him of my other possible causes: namely, an eye infection and

being off interferon for the first time in 6 years.

My routine would consist of LDN at night as per Bihari, and during

the day when I felt low or was falling a lot, occasional use of ULDN.

The effects of ULDN were not immediate, probably because I used too

much. It took about an hour to work.

Thought some might want to know.

Also, Dr. Crain mentioned the IBS trial success and said that that

use was in what he considers the high dose range, similar to what Dr.

Bihari is using. They took 0.5 mg per day.

-Sullivan

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