Chris....Just a question

[Guest guest]

Hi Chris....where did you read that interferon's raise the endorphins.

Strange thing....when I first took the ldn I was on Rebif. The first 1.5 mg. I stood alone. Then no spasms, and my right arm was mine again. It would get weak in the bath but after ldn it felt strong and manageable. Then I took 3.0 and all what I had gained just went away. Then I figured 2.0 was the mg. I should be taking. Then I stopped the ldn because of the headaches. I wanted to scientifically eliminate all the drugs so to find out why I was getting headaches. Well, went off the rebif still had headaches but here is the strange thing...I did not feel like I originally felt. I wasn't feeling strong, and energized but still not the same not like I originally felt. Did find out I have TMJ. TMJ does cause much discomfort and headaches. Well, I am a die heart I tried the ldn again. Boy, head filled up ...felt like someone had a clamp around my head then the feeling went away around 3pm in the afternoon. The jury is still out on the side effects I am experiencing. Hoping it is sinus and flonase will help. If I cannot take ldn I will seriously look into 4AP but there are seizures involved.

Cabbie

[Guest guest]

Arch Neurol. 2000 Aug;57(8):1178-81. Related Articles, Links

Beta-endorphin concentrations in peripheral blood mononuclear cells

of patients with multiple sclerosis: effects of treatment with

interferon beta.

Gironi M, elli V, Brambilla E, Furlan R, Panerai AE, Comi G,

Sacerdote P.

Neurology Department, San Raffaele Hospital, Via Olgettina 48, Milan,

Italy. maira.gironi@...

CONTEXT: It has been reported that the opioid peptide beta-endorphin

(BE) has immunosuppressive effects. Interferon beta (IFN-beta) is a

well-established therapy for multiple sclerosis (MS), but

immunological mechanisms underlying its beneficial effects in MS are

partially undefined. OBJECTIVES: To determine BE levels in peripheral

blood mononuclear cells (PBMCs) of patients with relapsing-remitting

MS during different phases of disease activity and the possible

modulating effects of IFN-beta treatment on PBMC BE synthesis in

patients with MS. DESIGN: We measured BE levels in blood samples

collected from 6 patients with MS who had not experienced clinical

changes during the previous 3 months (patients with stable MS) and

from 7 patients with MS during a clinical relapse. We also surveyed

BE levels in PBMC samples from 8 patients with MS before treatment

and for 6 months after the beginning of IFN-beta administration. The

control group was 13 healthy subjects. RESULTS: Low PBMC BE levels

were detected in patients with stable MS and in those entering IFN-

beta treatment compared with control subjects. Increased BE

concentrations were observed in MS patients experiencing a clinical

relapse compared with patients with stable MS. During IFN-beta

treatment, the levels of BE in PBMC samples from patients with MS

increased significantly (after 1 month, P =.02; after 3 months, P

=.007; and after 6 months, P =.16). CONCLUSIONS: A reduction of BE

levels was present in patients with clinically inactive MS. Treatment

with IFN-beta seems to induce an increase of this opioid in PBMCs of

MS patients. The increase of BE concentration during a clinical

relapse may represent a possible control mechanism aimed at

counterbalancing the inflammatory phase of the disease. Arch Neurol.

2000;57:1178-1181

PMID: 10927798 [PubMed - indexed for MEDLINE]

-This is the paper I was referring to. I would like to see this

stuff reproduced or at least evidence that the effect of circadian

release was taken into account.

-Sullivan

> Hi Chris....where did you read that interferon's raise the

endorphins.

>

> Strange thing....when I first took the ldn I was on Rebif. The

first 1.5 mg.

> I stood alone. Then no spasms, and my right arm was mine again.

It would

> get weak in the bath but after ldn it felt strong and manageable.

Then I took

> 3.0 and all what I had gained just went away. Then I figured 2.0

was the mg.

> I should be taking. Then I stopped the ldn because of the

headaches. I

> wanted to scientifically eliminate all the drugs so to find out why

I was getting

> headaches. Well, went off the rebif still had headaches but here

is the

> strange thing...I did not feel like I originally felt. I wasn't

feeling strong, and

> energized but still not the same not like I originally felt. Did

find out I

> have TMJ. TMJ does cause much discomfort and headaches. Well, I

am a die

> heart I tried the ldn again. Boy, head filled up ...felt like

someone had a clamp

> around my head then the feeling went away around 3pm in the

afternoon. The

> jury is still out on the side effects I am experiencing. Hoping it

is sinus

> and flonase will help. If I cannot take ldn I will seriously look

into 4AP but

> there are seizures involved.

>

> Cabbie