Fwd: [jjworld] World of MS Update Service

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>WORLD OF MS UPDATE SERVICE, 23 December 2003

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>MSIF News

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>Global Dinner Party 2004

>--------------------

>Join people worldwide in the fight against multiple sclerosis - host a

>party for your family and friends to support the MS cause and help end the

>effects of this life-long disease.

>

>Simply sign in on the MSIF website to find out more.

>http://www.msif.org/applications/people_profiles/index.rm

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>People With MS News

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>US National MS Society's Summary Of Research Progress - 2003

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>The NMSS has summarised the progress seen in MS research around the world

>in 2003.

>http://www.msif.org/go.rm?id=10922

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>Research News

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>Problems in diagnosing cranial base meningioma in patients with multiple

>sclerosis

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>The diagnostic challenge posed by dual pathology in patients affected by MS

>is highlighted by this case report of a cranial base meningioma.

>http://www.msif.org/go.rm?id=10923

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>The transition from relapsing-remitting MS to irreversible disability:

>clinical evaluation

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>A review article discussing possible disease mechanisms underlying the

>development of progressive disability in MS.

>http://www.msif.org/go.rm?id=10924

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>The same TCR (N)Dbeta(N)Jbeta junctional region is associated with several

>different vbeta13 subtypes in a multiple sclerosis patient at the onset of

>the disease

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>This study finds differences in the T-cell repertoire of patients with MS

>in comparison with healthy control subjects. Vbeta13 cell clones are found

>to be expanded in the cerebrospinal fluid but no particular Vbeta13

>rearrangement is found to be myelin autoreactive. Associations between

>Vbeta13 segments and other regions are also described and discussed.

>http://www.msif.org/go.rm?id=10925

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>Levetiracetam for phasic spasticity in multiple sclerosis

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>A retrospective medical record review of 12 patients affected by MS and

>spasticity treated with the anti-epileptic drug, levetiracetam. The drug is

>reported to be well tolerated and an effect on phasic, but not tonic,

>spasticity is described.

>http://www.msif.org/go.rm?id=10926

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>Atrophy is detectable within a 3-month period in untreated patients with

>active relapsing remitting multiple sclerosis

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>Accurate measurements of brain volume (brain parenchymal fraction) allow

>small changes in volume to be detected over periods as short as three

>months, according to the authors of this MRI based study, and allow

>calculation of an annualised atrophy rate. The short-term relation between

>inflammation, as assessed by gadolinium enhancement, and atrophy is found

>to be weak.

>http://www.msif.org/go.rm?id=10927

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>Magnetic resonance studies of abnormalities in the normal appearing white

>matter and grey matter in multiple sclerosis

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>A comprehensive review article looking at studies that have examined

>abnormalities in tissues that appear normal in conventional MRI imaging.

>http://www.msif.org/go.rm?id=10928

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>Concurrence of multiple sclerosis and intracranial glioma. Report of a case

>and review of the literature

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>A case report of glioma in a patient with an established diagnosis of MS,

>again emphasising the potential difficulties posed by dual pathology.

>http://www.msif.org/go.rm?id=10929

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>Lack of Association between Leber's Hereditary Optic Neuropathy Primary

>Point Mutations and Multiple Sclerosis in Iran

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>Case reports of the mitochondrial gene point mutation associated with

>Leber's hereditary optic neuropathy occurring in patients affected by MS

>have suggested a possible role for mitochondrial genes in MS

>susceptibility. An examination of patients affected by MS from Iran however

>does not find this association.

>http://www.msif.org/go.rm?id=10931

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>Mapping Multiple Sclerosis Susceptibility to the HLA-DR Locus in African

>Americans

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>A study making use of the greater haplotypic diversity of African

>populations to try and better localise the HLA gene responsible for MS

>susceptibility. A selective association with HLA-DRB1*15 was revealed,

>indicating a primary role for the DRB1 locus in MS independent of DQB1*0602.

>http://www.msif.org/go.rm?id=10932

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>Does trauma trigger multiple sclerosis? 2: A medicolegal view

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>Medicolegal aspects of this controversial question are discussed in this

>article.

>http://www.msif.org/go.rm?id=10933

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>Call for ICODIMS abstracts

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>The International Committee on Databases in MS (ICODIMS) will be holding a

>special session for the presentation of database related research at the

>CMSC Annual Meeting to be held in Toronto, Ontario, Canada on June 2-6 of

>2004. Investigators involved in research in the broad field of MS using

>clinical or research databases are encouraged to submit abstracts for

>presentation at this special symposium. Presentations can be in poster form

>and selected presentations will be asked to provide a 20-minute platform

>presentation during the special session.

>

>Abstracts must be submitted by February 27th, 2004

>http://www.mscare.org/members.cfm?sec_id=annual & doc_id=128

>

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