Guest guest Posted January 14, 2008 Report Share Posted January 14, 2008 I emailed the following post before I left for work this morning but I cannot see it anywhere so I'll re-post it, Cris ........... Hi Belinda, re TIMING OF DOSE & METABOLISM & CAPSULE FILLER We all understand LDN is most effective when the dose is taken between 10pm and 2am, however; I don't believe this is the only variable factor necessitating consideration when targeting optimum efficacy. Metabolism is another variable factor that must be considered, especially when working with such small doses. Each person's metabolism is different - we metabolise foods, medications, etc differently. Also, a person's normal metabolism can change over short or long periods of time - weeks, days, even hours - in response to other variable lifestyle factors such as changes in diet, exercise, supplements, medications, etc. Antioxidants, for example; as supplements, detoxes, or even teas or dark chocolate; can speed metabolism (speed exit). This means it's unlikely every person can take advantage of the full four-hour (10pm to 2am) medication window and achieve optimum efficacy. Perhaps ... a) Those with a slow metabolism may benefit most from the earliest dosage window for LDN. Those with a fast metabolism may benefit most from the latest dosage window for LDN. You know your own body better than anyone else - so please give consideration to your own normal metabolism, and consider anything that could be impacting metabolisation of LDN. Speed of metabolism is also relevant to choice of capsule fillers: Some time back now it was determined that calcium carbonate was not the ideal filler in LDN capsules because it had a tendency to compact and therefore, could slow down release of the active ingredient (Naltrexone). For those who already had a slow metabolism, you can see how a delay in the release of the active ingredient could very well be counterproductive. To summarise, in my (unqualified) opinion, the bottom line here is this ... 1. As the Naltrexone dose is minute, the timing of each person's dose will be dependent on multiple variable factors that must be given due consideration if optimum efficacy is to be achieved. 2. Antioxidants (and anything else that may interfere with metabolising LDN) should not be taken in the evening near to when you take your LDN as they may negatively impact metabolisation of such a small dose of Naltrexone. Kind regards, Cris casehealth.com.au Quote Link to comment Share on other sites More sharing options...
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