Guest guest Posted January 11, 2008 Report Share Posted January 11, 2008 Hi: After reading all your posts about adrenal insufficiencies and other complications,I have to tell one thing. " Plasmatic cortisol(steroid of the body) is produce mainly by adrenal glands between 2am and 9am, so prednisone or any steroid has to be taken between this hours to pass unnoticed " Someone who takes steroids out of this hours can be expose to all the side effects of steroids, including adrenal insufficiency, because when adrenal glands find steroids on unusual hours, they leave their production. I remember when I had my first symptom of MS(1993), the doctor prescribe me 80mgs of oral prednisone early in the morning and all together. Some doctors say that if you need a very high dose,you can divide in two takes(1 in the morning 1 in the afternoon), but I dont like this way because if you need a very high dose you better use IV Solumedrol. I have 7 years taking a manteinance dose of prednisone(7.5 mg) and I dont have any of the side effects of steroids. Guillermo Quote Link to comment Share on other sites More sharing options...
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